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GLYATL1 glycine-N-acyltransferase like 1 [ Homo sapiens (human) ]

Gene ID: 92292, updated on 2-Nov-2024

Summary

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Official Symbol
GLYATL1provided by HGNC
Official Full Name
glycine-N-acyltransferase like 1provided by HGNC
Primary source
HGNC:HGNC:30519
See related
Ensembl:ENSG00000166840 MIM:614761; AllianceGenome:HGNC:30519
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GNAT; GATF-C
Summary
Enables glutamine N-acyltransferase activity. Involved in glutamine metabolic process. Predicted to be located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in kidney (RPKM 74.7), liver (RPKM 64.2) and 1 other tissue See more
Orthologs
all
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Genomic context

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See GLYATL1 in Genome Data Viewer
Location:
11q12.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (58905481..58956406)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (58854982..58905920)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (58672954..58723879)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene translation machinery associated 16 homolog pseudogene 1 Neighboring gene glycine-N-acyltransferase like 2 Neighboring gene glycine-N-acyltransferase like 1 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:58672857-58673356 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:58694840-58695354 Neighboring gene uncharacterized LOC283194 Neighboring gene protein kinase cAMP-dependent type II regulatory subunit beta pseudogene Neighboring gene glycine-N-acyltransferase like 1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization of glycine-N-acyltransferase like 1 (GLYATL1) in prostate cancer. Eich ML, et al. Prostate, 2019 Oct. PMID 31376196
  2. Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma. Matsuo M, et al. Biochem Biophys Res Commun, 2012 Apr 20. PMID 22475485
  3. Severe Acute Respiratory Syndrome Coronavirus 2 ORF8 Protein Inhibits Type I Interferon Production by Targeting HSP90B1 Signaling. Chen J, et al. Front Cell Infect Microbiol, 2022. PMID 35677655, Free PMC Article
  4. Identification of proteins that interact with alpha A-crystallin using a human proteome microarray. Fan Q, et al. Mol Vis, 2014. PMID 24453475, Free PMC Article
  5. High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface. Datta S, et al. Cell Chem Biol, 2023 Oct 19. PMID 37499664

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ26507, FLJ34646, FLJ60524, MGC15397, MGC15937

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glutamine N-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamine N-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycine N-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glycine N-acyltransferase-like protein 1
Names
acyl-CoA:glycine N-acyltransferase-like protein 1
glutamine N-acyltransferase
NP_001207423.1
NP_001207425.1
NP_001341628.1
NP_001376640.1
NP_001376641.1
NP_001376642.1
NP_001376643.1
NP_001376644.1
NP_001376645.1
NP_001376646.1
NP_001376647.1
NP_542392.2
XP_011543656.1
XP_011543657.1
XP_011543658.1
XP_011543659.1
XP_011543660.1
XP_011543661.1
XP_054226487.1
XP_054226488.1
XP_054226489.1
XP_054226490.1
XP_054226491.1
XP_054226492.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001220494.4 → NP_001207423.1  glycine N-acyltransferase-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001207423.1

    Status: VALIDATED

    Source sequence(s)
    AP001636, AP001652, KF459756
    Consensus CDS
    CCDS55768.1
    UniProtKB/Swiss-Prot
    A6NDT0, Q7Z510, Q8NAW8, Q969I3
    UniProtKB/TrEMBL
    A9ZM15, B4DU33, E7ERD5
    Related
    ENSP00000322223.4, ENST00000317391.8
    Conserved Domains (2) summary
    pfam08444
    Location:208 → 296
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:1 → 207
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

  2. NM_001220496.4 → NP_001207425.1  glycine N-acyltransferase-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001207425.1

    Status: VALIDATED

    Source sequence(s)
    AP001636, KF459756
    Consensus CDS
    CCDS55768.1
    UniProtKB/Swiss-Prot
    A6NDT0, Q7Z510, Q8NAW8, Q969I3
    UniProtKB/TrEMBL
    A9ZM15, B4DU33, E7ERD5
    Related
    ENSP00000479741.1, ENST00000612196.1
    Conserved Domains (2) summary
    pfam08444
    Location:208 → 296
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:1 → 207
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

  3. NM_001354699.4 → NP_001341628.1  glycine N-acyltransferase-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP001636, AP001652, KF459756
    Consensus CDS
    CCDS55768.1
    UniProtKB/Swiss-Prot
    A6NDT0, Q7Z510, Q8NAW8, Q969I3
    UniProtKB/TrEMBL
    A9ZM15, B4DU33, E7ERD5
    Conserved Domains (2) summary
    pfam08444
    Location:208 → 296
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:1 → 207
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

  4. NM_001389711.2 → NP_001376640.1  glycine N-acyltransferase-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP001636, AP001652, KF459756
    Consensus CDS
    CCDS55768.1
    UniProtKB/Swiss-Prot
    A6NDT0, Q7Z510, Q8NAW8, Q969I3
    UniProtKB/TrEMBL
    A9ZM15, B4DU33, E7ERD5
    Conserved Domains (2) summary
    pfam08444
    Location:208 → 296
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:1 → 207
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

  5. NM_001389712.2 → NP_001376641.1  glycine N-acyltransferase-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP001636, KF459756
    Consensus CDS
    CCDS55768.1
    UniProtKB/Swiss-Prot
    A6NDT0, Q7Z510, Q8NAW8, Q969I3
    UniProtKB/TrEMBL
    A9ZM15, B4DU33, E7ERD5
    Related
    ENSP00000436116.2, ENST00000532726.6
    Conserved Domains (2) summary
    pfam08444
    Location:208 → 296
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:1 → 207
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

  6. NM_001389713.2 → NP_001376642.1  glycine N-acyltransferase-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP001636, KF459756
    Consensus CDS
    CCDS55768.1
    UniProtKB/Swiss-Prot
    A6NDT0, Q7Z510, Q8NAW8, Q969I3
    UniProtKB/TrEMBL
    A9ZM15, B4DU33, E7ERD5
    Conserved Domains (2) summary
    pfam08444
    Location:208 → 296
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:1 → 207
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

  7. NM_001389714.2 → NP_001376643.1  glycine N-acyltransferase-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP001636, AP001652, KF459756
    Consensus CDS
    CCDS55768.1
    UniProtKB/Swiss-Prot
    A6NDT0, Q7Z510, Q8NAW8, Q969I3
    UniProtKB/TrEMBL
    A9ZM15, B4DU33, E7ERD5
    Conserved Domains (2) summary
    pfam08444
    Location:208 → 296
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:1 → 207
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

  8. NM_001389715.2 → NP_001376644.1  glycine N-acyltransferase-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP001636, KF459756
    Consensus CDS
    CCDS55768.1
    UniProtKB/Swiss-Prot
    A6NDT0, Q7Z510, Q8NAW8, Q969I3
    UniProtKB/TrEMBL
    A9ZM15, B4DU33, E7ERD5
    Conserved Domains (2) summary
    pfam08444
    Location:208 → 296
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:1 → 207
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

  9. NM_001389716.2 → NP_001376645.1  glycine N-acyltransferase-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP001636, KF459756
    Consensus CDS
    CCDS55768.1
    UniProtKB/Swiss-Prot
    A6NDT0, Q7Z510, Q8NAW8, Q969I3
    UniProtKB/TrEMBL
    A9ZM15, B4DU33, E7ERD5
    Conserved Domains (2) summary
    pfam08444
    Location:208 → 296
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:1 → 207
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

  10. NM_001389717.2 → NP_001376646.1  glycine N-acyltransferase-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP001636, AP001652, KF459756
    Consensus CDS
    CCDS55768.1
    UniProtKB/Swiss-Prot
    A6NDT0, Q7Z510, Q8NAW8, Q969I3
    UniProtKB/TrEMBL
    A9ZM15, B4DU33, E7ERD5
    Conserved Domains (2) summary
    pfam08444
    Location:208 → 296
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:1 → 207
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

  11. NM_001389718.2 → NP_001376647.1  glycine N-acyltransferase-like protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AP001636, AP001652, KF459756
    Consensus CDS
    CCDS91475.1
    UniProtKB/TrEMBL
    A0A8I5KR82, B4DU33, E7ERD5
    Related
    ENSP00000510029.1, ENST00000685442.1
    Conserved Domains (2) summary
    pfam06021
    Location:1 → 166
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase
    cl17182
    Location:167 → 255
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

  12. NM_080661.6 → NP_542392.2  glycine N-acyltransferase-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_542392.2

    Status: VALIDATED

    Source sequence(s)
    AP001636, KF459756
    Consensus CDS
    CCDS31556.1
    UniProtKB/Swiss-Prot
    Q969I3
    Related
    ENSP00000300079.5, ENST00000300079.9
    Conserved Domains (2) summary
    pfam08444
    Location:239 → 327
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:51 → 238
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    58905481..58956406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545357.3 → XP_011543659.1  glycine N-acyltransferase-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543659.1

    UniProtKB/TrEMBL
    A0A8I5KVG3
    Conserved Domains (2) summary
    pfam08444
    Location:231 → 319
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:43 → 230
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

  2. XM_011545355.3 → XP_011543657.1  glycine N-acyltransferase-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543657.1

    UniProtKB/TrEMBL
    A0A8I5KVG3
    Conserved Domains (2) summary
    pfam08444
    Location:231 → 319
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:43 → 230
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

  3. XM_011545356.3 → XP_011543658.1  glycine N-acyltransferase-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543658.1

    UniProtKB/TrEMBL
    A0A8I5KVG3
    Conserved Domains (2) summary
    pfam08444
    Location:231 → 319
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:43 → 230
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

  4. XM_011545354.3 → XP_011543656.1  glycine N-acyltransferase-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543656.1

    UniProtKB/TrEMBL
    A0A8I5KVG3
    Related
    ENSP00000508694.1, ENST00000689150.1
    Conserved Domains (2) summary
    pfam08444
    Location:231 → 319
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:43 → 230
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

  5. XM_011545358.4 → XP_011543660.1  glycine N-acyltransferase-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543660.1

    UniProtKB/TrEMBL
    A0A8I5KVG3
    Conserved Domains (2) summary
    pfam08444
    Location:231 → 319
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:43 → 230
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

  6. XM_011545359.3 → XP_011543661.1  glycine N-acyltransferase-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011543661.1

    UniProtKB/TrEMBL
    A0A8I5KVG3
    Conserved Domains (2) summary
    pfam08444
    Location:231 → 319
    Gly_acyl_tr_C; Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region
    pfam06021
    Location:43 → 230
    Gly_acyl_tr_N; Aralkyl acyl-CoA:amino acid N-acyltransferase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    58854982..58905920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370515.1 → XP_054226490.1  glycine N-acyltransferase-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVG3

  2. XM_054370513.1 → XP_054226488.1  glycine N-acyltransferase-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVG3

  3. XM_054370514.1 → XP_054226489.1  glycine N-acyltransferase-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVG3

  4. XM_054370512.1 → XP_054226487.1  glycine N-acyltransferase-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVG3

  5. XM_054370516.1 → XP_054226491.1  glycine N-acyltransferase-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVG3

  6. XM_054370517.1 → XP_054226492.1  glycine N-acyltransferase-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVG3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q969I3.1 GenPept UniProtKB/Swiss-Prot:Q969I3

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