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ZMYM4 zinc finger MYM-type containing 4 [ Homo sapiens (human) ]

Gene ID: 9202, updated on 1-Jun-2020

Summary

Official Symbol
ZMYM4provided by HGNC
Official Full Name
zinc finger MYM-type containing 4provided by HGNC
Primary source
HGNC:HGNC:13055
See related
Ensembl:ENSG00000146463 MIM:613568
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYM; CDIR; ZNF262; ZNF198L3
Expression
Ubiquitous expression in testis (RPKM 15.0), ovary (RPKM 10.1) and 25 other tissues See more
Orthologs

Genomic context

See ZMYM4 in Genome Data Viewer
Location:
1p34.3
Exon count:
33
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (35268694..35422058)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (35734444..35887545)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378644 Neighboring gene splicing factor proline and glutamine rich Neighboring gene RNA, 7SL, cytoplasmic 503, pseudogene Neighboring gene ZMYM4 antisense RNA 1 Neighboring gene ribosomal protein L5 pseudogene 4 Neighboring gene KIAA0319 like Neighboring gene RNY5 pseudogene 1 Neighboring gene zinc finger protein 485 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0425, DKFZp686L0547, DKFZp686B09210

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
regulation of cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger MYM-type protein 4
Names
cell death inhibiting RNA
zinc finger protein 262
zinc finger, MYM-type 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001350138.2NP_001337067.1  zinc finger MYM-type protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' region, resulting in the use of a downstream start codon, compared the variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AB007885, AL356362, AL590434, BC012093, BC127113, BG499626, BU683493
    Conserved Domains (3) summary
    smart00746
    Location:357397
    TRASH; metallochaperone-like domain
    pfam06467
    Location:449489
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:13241493
    DUF3504; Domain of unknown function (DUF3504)
  2. NM_001350139.2NP_001337068.1  zinc finger MYM-type protein 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon, resulting in the use of a downstream start codon, compared the variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same protein (isoform 3).
    Source sequence(s)
    AB007885, AL356362, AL590434, BC012093, BG499626, BU683493, CD653525
    Conserved Domains (3) summary
    smart00746
    Location:65105
    TRASH; metallochaperone-like domain
    pfam06467
    Location:157197
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:10321201
    DUF3504; Domain of unknown function (DUF3504)
  3. NM_001350140.2NP_001337069.1  zinc finger MYM-type protein 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' region, and lacks three consecutive exons, resulting in the use of a downstream start codon, compared the variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3 and 4 encode the same protein (isoform 3).
    Source sequence(s)
    AB007885, AL356362, AL590434, BC127113, BG499626, BU683493
    Related
    ENSP00000400506.1, ENST00000457946.1
    Conserved Domains (3) summary
    smart00746
    Location:65105
    TRASH; metallochaperone-like domain
    pfam06467
    Location:157197
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:10321201
    DUF3504; Domain of unknown function (DUF3504)
  4. NM_001375653.1NP_001362582.1  zinc finger MYM-type protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL160000, AL356362, AL590434
  5. NM_005095.3NP_005086.2  zinc finger MYM-type protein 4 isoform 1

    See identical proteins and their annotated locations for NP_005086.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB007885, AL356362, AL590434, BC012093, BG499626, BU683493, CD653525
    Consensus CDS
    CCDS389.1
    UniProtKB/Swiss-Prot
    Q5VZL5
    Related
    ENSP00000322915.6, ENST00000314607.11
    Conserved Domains (3) summary
    smart00746
    Location:389429
    TRASH; metallochaperone-like domain
    pfam06467
    Location:478521
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:13561525
    DUF3504; Domain of unknown function (DUF3504)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    35268694..35422058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271331.2XP_005271388.1  zinc finger MYM-type protein 4 isoform X3

    See identical proteins and their annotated locations for XP_005271388.1

    UniProtKB/Swiss-Prot
    Q5VZL5
    Conserved Domains (3) summary
    smart00746
    Location:65105
    TRASH; metallochaperone-like domain
    pfam06467
    Location:157197
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:10321201
    DUF3504; Domain of unknown function (DUF3504)
  2. XM_017002803.1XP_016858292.1  zinc finger MYM-type protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q5VZL5
    Conserved Domains (3) summary
    smart00746
    Location:357397
    TRASH; metallochaperone-like domain
    pfam06467
    Location:449489
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:13241493
    DUF3504; Domain of unknown function (DUF3504)
  3. XM_024450838.1XP_024306606.1  zinc finger MYM-type protein 4 isoform X3

    Conserved Domains (3) summary
    smart00746
    Location:65105
    TRASH; metallochaperone-like domain
    pfam06467
    Location:157197
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:10321201
    DUF3504; Domain of unknown function (DUF3504)
  4. XM_017002805.1XP_016858294.1  zinc finger MYM-type protein 4 isoform X4

    Conserved Domains (3) summary
    smart00746
    Location:144182
    TRASH; metallochaperone-like domain
    pfam06467
    Location:91134
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:9691138
    DUF3504; Domain of unknown function (DUF3504)

RNA

  1. XR_246305.4 RNA Sequence

  2. XR_001737542.1 RNA Sequence

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