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EOLA1 endothelium and lymphocyte associated ASCH domain 1 [ Homo sapiens (human) ]

Gene ID: 91966, updated on 2-May-2020

Summary

Official Symbol
EOLA1provided by HGNC
Official Full Name
endothelium and lymphocyte associated ASCH domain 1provided by HGNC
Primary source
HGNC:HGNC:28089
See related
Ensembl:ENSG00000197620 MIM:300954
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CXorf40; CXorf40A
Expression
Ubiquitous expression in adrenal (RPKM 8.2), bone marrow (RPKM 2.5) and 25 other tissues See more
Orthologs

Genomic context

See EOLA1 in Genome Data Viewer
Location:
Xq28
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (149540601..149555345)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (148622204..148632086)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized IDS2 Neighboring gene IDSP1 recombination region Neighboring gene long intergenic non-protein coding RNA 893 Neighboring gene iduronate 2-sulfatase pseudogene 1 Neighboring gene heat shock transcription factor family, X-linked member 3 Neighboring gene MAGE family member A9B Neighboring gene heat shock transcription factor family, X-linked 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16423, FLJ52212

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein EOLA1; protein CXorf40A
Names
endothelial-overexpressed lipopolysaccharide-associated factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171907.3NP_001165378.1  protein EOLA1 isoform a

    See identical proteins and their annotated locations for NP_001165378.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1.
    Source sequence(s)
    AI088770, AW952651, BC104930, BF115859, CB156531, DC426016, L43576
    Consensus CDS
    CCDS14687.1
    UniProtKB/Swiss-Prot
    Q8TE69
    Related
    ENSP00000421745.1, ENST00000393985.8
    Conserved Domains (1) summary
    smart01022
    Location:6114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain
  2. NM_001171908.3NP_001165379.1  protein EOLA1 isoform a

    See identical proteins and their annotated locations for NP_001165379.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1.
    Source sequence(s)
    AI088770, AW952651, BC143662, BF115859, CB156531, DC426016, L43576
    Consensus CDS
    CCDS14687.1
    UniProtKB/Swiss-Prot
    Q8TE69
    Related
    ENSP00000425520.1, ENST00000423540.6
    Conserved Domains (1) summary
    smart01022
    Location:6114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain
  3. NM_001171909.3NP_001165380.1  protein EOLA1 isoform b

    See identical proteins and their annotated locations for NP_001165380.1

    Status: VALIDATED

    Source sequence(s)
    AC244197, AK300334, BC065539, CR984770
    Consensus CDS
    CCDS55522.1
    UniProtKB/Swiss-Prot
    Q8TE69
    UniProtKB/TrEMBL
    A0A0A0MTB5
    Related
    ENSP00000422312.1, ENST00000422892.2
    Conserved Domains (1) summary
    smart01022
    Location:6114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain
  4. NM_001324274.2NP_001311203.1  protein EOLA1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC244197, BG105508, DC339764
    Consensus CDS
    CCDS14687.1
    UniProtKB/Swiss-Prot
    Q8TE69
    Related
    ENSP00000427540.1, ENST00000450602.6
    Conserved Domains (1) summary
    smart01022
    Location:6114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain
  5. NM_001324275.2NP_001311204.1  protein EOLA1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC244197, BG105508, BI819316
    Consensus CDS
    CCDS14687.1
    UniProtKB/Swiss-Prot
    Q8TE69
    Conserved Domains (1) summary
    smart01022
    Location:6114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain
  6. NM_001324276.2NP_001311205.1  protein EOLA1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC244197
    Consensus CDS
    CCDS55522.1
    UniProtKB/TrEMBL
    A0A0A0MTB5
    Related
    ENSP00000423160.1, ENST00000434353.6
    Conserved Domains (1) summary
    smart01022
    Location:6114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain
  7. NM_001324277.2NP_001311206.1  protein EOLA1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC244197
    Consensus CDS
    CCDS14687.1
    UniProtKB/Swiss-Prot
    Q8TE69
    Related
    ENSP00000423099.1, ENST00000441248.5
    Conserved Domains (1) summary
    smart01022
    Location:6114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain
  8. NM_001324278.2NP_001311207.1  protein EOLA1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC244197
    Consensus CDS
    CCDS14687.1
    UniProtKB/Swiss-Prot
    Q8TE69
    Conserved Domains (1) summary
    smart01022
    Location:6114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain
  9. NM_001324279.2NP_001311208.1  protein EOLA1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC244197
    Consensus CDS
    CCDS55522.1
    UniProtKB/TrEMBL
    A0A0A0MTB5
    Conserved Domains (1) summary
    smart01022
    Location:6114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain
  10. NM_001324280.2NP_001311209.1  protein EOLA1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC244197
    Consensus CDS
    CCDS14687.1
    UniProtKB/Swiss-Prot
    Q8TE69
    Conserved Domains (1) summary
    smart01022
    Location:6114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain
  11. NM_178124.6NP_835225.2  protein EOLA1 isoform a

    See identical proteins and their annotated locations for NP_835225.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AI088770, AW952651, BC065539, BF115859, CB156531, DC426016, L43576
    Consensus CDS
    CCDS14687.1
    UniProtKB/Swiss-Prot
    Q8TE69
    Related
    ENSP00000422512.1, ENST00000423421.5
    Conserved Domains (1) summary
    smart01022
    Location:6114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    149540601..149555345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452480.1XP_024308248.1  protein CXorf40A isoform X2

    Related
    ENSP00000423708.1, ENST00000514208.5
    Conserved Domains (1) summary
    smart01022
    Location:6114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain
  2. XM_005262349.4XP_005262406.2  protein CXorf40A isoform X1

    See identical proteins and their annotated locations for XP_005262406.2

    UniProtKB/Swiss-Prot
    Q8TE69
    Related
    ENSP00000420882.1, ENST00000359293.5
    Conserved Domains (1) summary
    smart01022
    Location:6114
    ASCH; The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain
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