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SLFN11 schlafen family member 11 [ Homo sapiens (human) ]

Gene ID: 91607, updated on 2-Nov-2024

Summary

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Official Symbol
SLFN11provided by HGNC
Official Full Name
schlafen family member 11provided by HGNC
Primary source
HGNC:HGNC:26633
See related
Ensembl:ENSG00000172716 MIM:614953; AllianceGenome:HGNC:26633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLFN8/9
Summary
Enables ATP hydrolysis activity and tRNA binding activity. Involved in several processes, including defense response to virus; negative regulation of G1/S transition of mitotic cell cycle; and replication fork arrest. Located in cytosol; nucleoplasm; and site of DNA damage. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung (RPKM 14.8), thyroid (RPKM 12.0) and 24 other tissues See more
Orthologs
all
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Genomic context

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See SLFN11 in Genome Data Viewer
Location:
17q12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (35350305..35373621, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (36298255..36321577, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (33677324..33700640, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371932 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:33570506-33571134 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:33583732-33584931 Neighboring gene schlafen family member 5 Neighboring gene NANOG hESC enhancer GRCh37_chr17:33638706-33639207 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33640386-33641045 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:33641707-33642365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33660479-33660980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33660981-33661480 Neighboring gene RING-box protein 2-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12063 Neighboring gene uncharacterized LOC105371933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12066 Neighboring gene UFM1 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33720941-33721442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33721443-33721942 Neighboring gene DTW domain containing 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SLFN11 inhibits hepatocellular carcinoma tumorigenesis and metastasis by targeting RPS4X via mTOR pathway. Zhou C, et al. Theranostics, 2020. PMID 32292519, Free PMC Article
  2. SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells. Okamoto Y, et al. Blood, 2021 Jan 21. PMID 32735670, Free PMC Article
  3. Epigenetic suppression of SLFN11 in germinal center B-cells during B-cell development. Moribe F, et al. PLoS One, 2021. PMID 33513156, Free PMC Article
  4. SLFN11 Expression in Advanced Prostate Cancer and Response to Platinum-based Chemotherapy. Conteduca V, et al. Mol Cancer Ther, 2020 May. PMID 32127465, Free PMC Article
  5. Schlafen 11 predicts response to platinum-based chemotherapy in gastric cancers. Takashima T, et al. Br J Cancer, 2021 Jul. PMID 33785877, Free PMC Article

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA.
    Title: Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA.
  2. SLFN11 promotes clear cell renal cell carcinoma progression via the PI3K/AKT signaling pathway.
    Title: SLFN11 promotes clear cell renal cell carcinoma progression via the PI3K/AKT signaling pathway.
  3. Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.
    Title: Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response.
  4. SLFN11 negatively regulates non-canonical NFkB signaling to promote glioblastoma progression.
    Title: SLFN11 negatively regulates non-canonical NFkB signaling to promote glioblastoma progression.
  5. Mechanistic understanding of human SLFN11.
    Title: Mechanistic understanding of human SLFN11.
  6. Dynamic expression of Schlafen 11 (SLFN11) in circulating tumour cells as a liquid biomarker in small cell lung cancer.
    Title: Dynamic expression of Schlafen 11 (SLFN11) in circulating tumour cells as a liquid biomarker in small cell lung cancer.
  7. FK228 potentiates topotecan activity against small cell lung cancer cells via induction of SLFN11.
    Title: FK228 potentiates topotecan activity against small cell lung cancer cells via induction of SLFN11.
  8. SLFN11 is Widely Expressed in Pediatric Sarcoma and Induces Variable Sensitization to Replicative Stress Caused By DNA-Damaging Agents.
    Title: SLFN11 is Widely Expressed in Pediatric Sarcoma and Induces Variable Sensitization to Replicative Stress Caused By DNA-Damaging Agents.
  9. SLFN11 captures cancer-immunity interactions associated with platinum sensitivity in high-grade serous ovarian cancer.
    Title: SLFN11 captures cancer-immunity interactions associated with platinum sensitivity in high-grade serous ovarian cancer.
  10. Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex.
    Title: Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex.
Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ34922

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in replication fork arrest IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in site of DNA damage IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
schlafen family member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001104587.2 → NP_001098057.1  schlafen family member 11

    See identical proteins and their annotated locations for NP_001098057.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All 16 variants encode the same protein.
    Source sequence(s)
    AC060766, AK092241, BC052586, BM996330, BP245452, BX490030
    Consensus CDS
    CCDS11294.1
    UniProtKB/Swiss-Prot
    E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
    Conserved Domains (2) summary
    PHA02782
    Location:15 → 348
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:595 → 714
    DUF2075; Uncharacterized conserved protein (DUF2075)

  2. NM_001104588.2 → NP_001098058.1  schlafen family member 11

    See identical proteins and their annotated locations for NP_001098058.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All 16 variants encode the same protein.
    Source sequence(s)
    AC060766, BC052586, BM996330, BP245452
    Consensus CDS
    CCDS11294.1
    UniProtKB/Swiss-Prot
    E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
    Conserved Domains (2) summary
    PHA02782
    Location:15 → 348
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:595 → 714
    DUF2075; Uncharacterized conserved protein (DUF2075)

  3. NM_001104589.2 → NP_001098059.1  schlafen family member 11

    See identical proteins and their annotated locations for NP_001098059.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All 16 variants encode the same protein.
    Source sequence(s)
    AC060766, BC052586, BM996330, BP245452, CB265500
    Consensus CDS
    CCDS11294.1
    UniProtKB/Swiss-Prot
    E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
    Conserved Domains (2) summary
    PHA02782
    Location:15 → 348
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:595 → 714
    DUF2075; Uncharacterized conserved protein (DUF2075)

  4. NM_001104590.2 → NP_001098060.1  schlafen family member 11

    See identical proteins and their annotated locations for NP_001098060.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All 16 variants encode the same protein.
    Source sequence(s)
    AC060766, AK092241, BC052586, BM996330, BP245452
    Consensus CDS
    CCDS11294.1
    UniProtKB/Swiss-Prot
    E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
    Related
    ENSP00000378067.1, ENST00000394566.5
    Conserved Domains (2) summary
    PHA02782
    Location:15 → 348
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:595 → 714
    DUF2075; Uncharacterized conserved protein (DUF2075)

  5. NM_001376007.1 → NP_001362936.1  schlafen family member 11

    Status: VALIDATED

    Source sequence(s)
    AC060766
    Consensus CDS
    CCDS11294.1
    UniProtKB/Swiss-Prot
    E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
    Related
    ENSP00000510787.1, ENST00000685675.1
    Conserved Domains (2) summary
    PHA02782
    Location:15 → 348
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:595 → 714
    DUF2075; Uncharacterized conserved protein (DUF2075)

  6. NM_001376008.1 → NP_001362937.1  schlafen family member 11

    Status: VALIDATED

    Source sequence(s)
    AC060766
    Consensus CDS
    CCDS11294.1
    UniProtKB/Swiss-Prot
    E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
    Conserved Domains (2) summary
    PHA02782
    Location:15 → 348
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:595 → 714
    DUF2075; Uncharacterized conserved protein (DUF2075)

  7. NM_001376009.1 → NP_001362938.1  schlafen family member 11

    Status: VALIDATED

    Source sequence(s)
    AC060766
    Consensus CDS
    CCDS11294.1
    UniProtKB/Swiss-Prot
    E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
    Conserved Domains (2) summary
    PHA02782
    Location:15 → 348
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:595 → 714
    DUF2075; Uncharacterized conserved protein (DUF2075)

  8. NM_001376010.1 → NP_001362939.1  schlafen family member 11

    Status: VALIDATED

    Source sequence(s)
    AC060766
    Consensus CDS
    CCDS11294.1
    UniProtKB/Swiss-Prot
    E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
    Conserved Domains (2) summary
    PHA02782
    Location:15 → 348
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:595 → 714
    DUF2075; Uncharacterized conserved protein (DUF2075)

  9. NM_001376011.1 → NP_001362940.1  schlafen family member 11

    Status: VALIDATED

    Source sequence(s)
    AC060766
    Consensus CDS
    CCDS11294.1
    UniProtKB/Swiss-Prot
    E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
    Conserved Domains (2) summary
    PHA02782
    Location:15 → 348
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:595 → 714
    DUF2075; Uncharacterized conserved protein (DUF2075)

  10. NM_001387158.1 → NP_001374087.1  schlafen family member 11

    Status: VALIDATED

    Source sequence(s)
    AC060766
    Consensus CDS
    CCDS11294.1
    UniProtKB/Swiss-Prot
    E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
    Conserved Domains (2) summary
    PHA02782
    Location:15 → 348
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:595 → 714
    DUF2075; Uncharacterized conserved protein (DUF2075)

  11. NM_001387159.1 → NP_001374088.1  schlafen family member 11

    Status: VALIDATED

    Source sequence(s)
    AC060766
    Consensus CDS
    CCDS11294.1
    UniProtKB/Swiss-Prot
    E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
    Conserved Domains (2) summary
    PHA02782
    Location:15 → 348
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:595 → 714
    DUF2075; Uncharacterized conserved protein (DUF2075)

  12. NM_001387160.1 → NP_001374089.1  schlafen family member 11

    Status: VALIDATED

    Source sequence(s)
    AC060766
    Consensus CDS
    CCDS11294.1
    UniProtKB/Swiss-Prot
    E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
    Conserved Domains (2) summary
    PHA02782
    Location:15 → 348
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:595 → 714
    DUF2075; Uncharacterized conserved protein (DUF2075)

  13. NM_001387161.1 → NP_001374090.1  schlafen family member 11

    Status: VALIDATED

    Source sequence(s)
    AC060766
    Consensus CDS
    CCDS11294.1
    UniProtKB/Swiss-Prot
    E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
    Conserved Domains (2) summary
    PHA02782
    Location:15 → 348
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:595 → 714
    DUF2075; Uncharacterized conserved protein (DUF2075)

  14. NM_001387162.1 → NP_001374091.1  schlafen family member 11

    Status: VALIDATED

    Source sequence(s)
    AC060766
    Consensus CDS
    CCDS11294.1
    UniProtKB/Swiss-Prot
    E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
    Conserved Domains (2) summary
    PHA02782
    Location:15 → 348
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:595 → 714
    DUF2075; Uncharacterized conserved protein (DUF2075)

  15. NM_001387163.1 → NP_001374092.1  schlafen family member 11

    Status: VALIDATED

    Source sequence(s)
    AC060766
    Consensus CDS
    CCDS11294.1
    UniProtKB/Swiss-Prot
    E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
    Conserved Domains (2) summary
    PHA02782
    Location:15 → 348
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:595 → 714
    DUF2075; Uncharacterized conserved protein (DUF2075)

  16. NM_152270.4 → NP_689483.3  schlafen family member 11

    See identical proteins and their annotated locations for NP_689483.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All 16 variants encode the same protein.
    Source sequence(s)
    AC060766, BC052586, BM996330, BP245452
    Consensus CDS
    CCDS11294.1
    UniProtKB/Swiss-Prot
    E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0
    Related
    ENSP00000312402.4, ENST00000308377.8
    Conserved Domains (2) summary
    PHA02782
    Location:15 → 348
    PHA02782; hypothetical protein; Provisional
    pfam09848
    Location:595 → 714
    DUF2075; Uncharacterized conserved protein (DUF2075)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    35350305..35373621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437042.1 → XP_047292998.1  schlafen family member 11 isoform X1

    UniProtKB/Swiss-Prot
    E1P643, Q7Z7L1, Q8N3S8, Q8N762, Q8TEE0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    36298255..36321577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317762.1 → XP_054173737.1  schlafen family member 11 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001376012.1: Suppressed sequence

    Description
    NM_001376012.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z7L1.2 GenPept UniProtKB/Swiss-Prot:Q7Z7L1

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