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RPS19BP1 ribosomal protein S19 binding protein 1 [ Homo sapiens (human) ]

Gene ID: 91582, updated on 20-Nov-2022

Summary

Official Symbol
RPS19BP1provided by HGNC
Official Full Name
ribosomal protein S19 binding protein 1provided by HGNC
Primary source
HGNC:HGNC:28749
See related
Ensembl:ENSG00000187051 MIM:610225; AllianceGenome:HGNC:28749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AROS; S19BP
Summary
Enables enzyme binding activity. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 26.6), prostate (RPKM 24.3) and 25 other tissues See more
Orthologs
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Genomic context

See RPS19BP1 in Genome Data Viewer
Location:
22q13.1
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (39529093..39532748, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (39999723..40003378, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (39925098..39928753, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373035 Neighboring gene mitochondrial elongation factor 1 Neighboring gene activating transcription factor 4 Neighboring gene uncharacterized LOC124905120 Neighboring gene calcium voltage-gated channel subunit alpha1 I Neighboring gene Sharpr-MPRA regulatory region 12417

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21770, MGC52010, dJ1104E15.4

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
active regulator of SIRT1
Names
40S ribosomal protein S19-binding protein 1
RPS19-binding protein 1
homolog of mouse S19 binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194326.4NP_919307.1  active regulator of SIRT1

    See identical proteins and their annotated locations for NP_919307.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the functional protein.
    Source sequence(s)
    BC037573
    Consensus CDS
    CCDS13997.1
    UniProtKB/Swiss-Prot
    Q5JZA1, Q86WX3
    UniProtKB/TrEMBL
    A0A024R1T1
    Related
    ENSP00000333948.3, ENST00000334678.8
    Conserved Domains (1) summary
    pfam15684
    Location:24133
    AROS; Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1

RNA

  1. NR_130151.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon, compared to variant 1. This variant is represented as non-coding because use of the supported translation start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BQ675376, CB142920
    Related
    ENST00000420879.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    39529093..39532748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    39999723..40003378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)