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DYRK1B dual specificity tyrosine phosphorylation regulated kinase 1B [ Homo sapiens (human) ]

Gene ID: 9149, updated on 7-Dec-2018

Summary

Official Symbol
DYRK1Bprovided by HGNC
Official Full Name
dual specificity tyrosine phosphorylation regulated kinase 1Bprovided by HGNC
Primary source
HGNC:HGNC:3092
See related
Ensembl:ENSG00000105204 MIM:604556
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRK; AOMS3
Summary
This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Expression
Broad expression in testis (RPKM 21.5), prostate (RPKM 4.7) and 23 other tissues See more
Orthologs

Genomic context

See DYRK1B in Genome Data Viewer
Location:
19q13.2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (39825347..39834233, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40315990..40324841, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Charcot-Leyden crystal galectin Neighboring gene leucine twenty homeobox Neighboring gene microRNA 6719 Neighboring gene fibrillarin Neighboring gene Fc fragment of IgG binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
adipose tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
myoblast fusion IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
dual specificity tyrosine-phosphorylation-regulated kinase 1B
Names
dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
minibrain-related kinase
mirk protein kinase
NP_004705.1
NP_006474.1
NP_006475.1
XP_005259455.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034145.1 RefSeqGene

    Range
    5001..13887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004714.3NP_004705.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p69

    See identical proteins and their annotated locations for NP_004705.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as 'a') represents the longest transcript and encodes the longest isoform (p69, also known as isoform a).
    Source sequence(s)
    Y17999
    Consensus CDS
    CCDS12543.1
    UniProtKB/Swiss-Prot
    Q9Y463
    UniProtKB/TrEMBL
    A0A024R0I0
    Related
    ENSP00000312789.4, ENST00000323039.9
    Conserved Domains (1) summary
    cd14226
    Location:97436
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
  2. NM_006483.2NP_006474.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p65

    See identical proteins and their annotated locations for NP_006474.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as 'b') uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (p65, also known as isoform b) is shorter than isoform p69.
    Source sequence(s)
    BI964831, BQ446787, HY024135, Y17999
    Consensus CDS
    CCDS46075.1
    UniProtKB/Swiss-Prot
    Q9Y463
    UniProtKB/TrEMBL
    A0A024R0J6
    Related
    ENSP00000403182.1, ENST00000430012.6
    Conserved Domains (1) summary
    cd14226
    Location:97396
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
  3. NM_006484.2NP_006475.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p66

    See identical proteins and their annotated locations for NP_006475.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as 'c') lacks an alternate in-frame segment in the 3' coding region, compared to variant 1. The encoded isoform (p66, also known as isoform c) is shorter than isoform p69.
    Source sequence(s)
    BI964831, BQ446787, HY024135, Y17999
    Consensus CDS
    CCDS12544.1
    UniProtKB/Swiss-Prot
    Q9Y463
    UniProtKB/TrEMBL
    A0A024R0M8
    Related
    ENSP00000221803.4, ENST00000348817.7
    Conserved Domains (1) summary
    cd14226
    Location:97408
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    39825347..39834233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259398.4XP_005259455.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1

    See identical proteins and their annotated locations for XP_005259455.1

    UniProtKB/Swiss-Prot
    Q9Y463
    UniProtKB/TrEMBL
    A0A024R0I0
    Related
    ENSP00000469863.1, ENST00000593685.5
    Conserved Domains (1) summary
    cd14226
    Location:97436
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_009646206.1 Reference GRCh38.p12 PATCHES

    Range
    85223..94109 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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