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SYNGR3 synaptogyrin 3 [ Homo sapiens (human) ]

Gene ID: 9143, updated on 7-Jun-2020

Summary

Official Symbol
SYNGR3provided by HGNC
Official Full Name
synaptogyrin 3provided by HGNC
Primary source
HGNC:HGNC:11501
See related
Ensembl:ENSG00000127561 MIM:603927
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes an integral membrane protein. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it is a synaptic vesicle protein that also interacts with the dopamine transporter. The gene product belongs to the synaptogyrin gene family. [provided by RefSeq, Dec 2010]
Expression
Biased expression in brain (RPKM 26.0), adrenal (RPKM 4.5) and 2 other tissues See more
Orthologs

Genomic context

See SYNGR3 in Genome Data Viewer
Location:
16p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (1989970..1994275)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2039946..2044276)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene transducin beta like 3 Neighboring gene NADPH oxidase organizer 1 Neighboring gene growth factor, augmenter of liver regeneration Neighboring gene zinc finger protein 598, E3 ubiquitin ligase Neighboring gene RNA, 7SL, cytoplasmic 219, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC20003

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH2 domain binding IEA
Inferred from Electronic Annotation
more info
 
protein N-terminus binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
neurotransmitter uptake IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulated exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
substantia nigra development HEP PubMed 
Component Evidence Code Pubs
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004209.6NP_004200.2  synaptogyrin-3

    See identical proteins and their annotated locations for NP_004200.2

    Status: REVIEWED

    Source sequence(s)
    AC005606, BC014087
    Consensus CDS
    CCDS10456.1
    UniProtKB/Swiss-Prot
    O43761
    Related
    ENSP00000248121.2, ENST00000248121.7
    Conserved Domains (1) summary
    pfam01284
    Location:20165
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    1989970..1994275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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