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CCDC74B coiled-coil domain containing 74B [ Homo sapiens (human) ]

Gene ID: 91409, updated on 23-Nov-2021

Summary

Official Symbol
CCDC74Bprovided by HGNC
Official Full Name
coiled-coil domain containing 74Bprovided by HGNC
Primary source
HGNC:HGNC:25267
See related
Ensembl:ENSG00000152076
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 21.7), endometrium (RPKM 3.3) and 8 other tissues See more
Orthologs
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Genomic context

See CCDC74B in Genome Data Viewer
Location:
2q21.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (130139283..130145112, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (130896860..130902685, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene fatty acyl-CoA reductase 2 pseudogene 1 Neighboring gene cytochrome P450 family 4 subfamily F member 27, pseudogene Neighboring gene POTE ankyrin domain family member F Neighboring gene RNA, U6 small nuclear 1049, pseudogene Neighboring gene POTEF antisense RNA 1 Neighboring gene mediator complex subunit 15 pseudogene 9 Neighboring gene sphingomyelin phosphodiesterase 4 Neighboring gene mitotic spindle organizing protein 2B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
coiled-coil domain-containing protein 74B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258307.2NP_001245236.1  coiled-coil domain-containing protein 74B isoform 2

    See identical proteins and their annotated locations for NP_001245236.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC018804
    Consensus CDS
    CCDS58726.1
    UniProtKB/Swiss-Prot
    Q96LY2
    Related
    ENSP00000386294.3, ENST00000409943.8
    Conserved Domains (2) summary
    pfam14916
    Location:47100
    CCDC92; Coiled-coil domain of unknown function
    pfam14917
    Location:197311
    CCDC74_C; Coiled coil protein 74, C terminal
  2. NM_207310.4NP_997193.1  coiled-coil domain-containing protein 74B isoform 1

    See identical proteins and their annotated locations for NP_997193.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC018804
    Consensus CDS
    CCDS2155.1
    UniProtKB/Swiss-Prot
    Q96LY2
    Related
    ENSP00000308873.6, ENST00000310463.10
    Conserved Domains (2) summary
    pfam14916
    Location:47100
    CCDC92; Coiled-coil domain of unknown function
    pfam14917
    Location:263377
    CCDC74_C; Coiled coil protein 74, C terminal

RNA

  1. NR_165309.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018804

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    130139283..130145112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712837.2XP_006712900.1  coiled-coil domain-containing protein 74B isoform X7

    Conserved Domains (2) summary
    pfam14916
    Location:47100
    CCDC92; Coiled-coil domain of unknown function
    pfam14917
    Location:201315
    CCDC74_C; Coiled coil protein 74, C terminal
  2. XM_006712834.3XP_006712897.1  coiled-coil domain-containing protein 74B isoform X4

    Conserved Domains (2) summary
    pfam14916
    Location:47100
    CCDC92; Coiled-coil domain of unknown function
    pfam14917
    Location:267381
    CCDC74_C; Coiled coil protein 74, C terminal
  3. XM_005263842.2XP_005263899.1  coiled-coil domain-containing protein 74B isoform X6

    Conserved Domains (2) summary
    pfam14916
    Location:4783
    CCDC92; Coiled-coil domain of unknown function
    pfam14917
    Location:239353
    CCDC74_C; Coiled coil protein 74, C terminal
  4. XM_006712835.2XP_006712898.1  coiled-coil domain-containing protein 74B isoform X5

    Conserved Domains (2) summary
    pfam14916
    Location:4783
    CCDC92; Coiled-coil domain of unknown function
    pfam14917
    Location:243357
    CCDC74_C; Coiled coil protein 74, C terminal
  5. XM_005263840.2XP_005263897.1  coiled-coil domain-containing protein 74B isoform X3

    Conserved Domains (2) summary
    pfam14916
    Location:4783
    CCDC92; Coiled-coil domain of unknown function
    pfam14917
    Location:305419
    CCDC74_C; Coiled coil protein 74, C terminal
  6. XM_006712833.2XP_006712896.1  coiled-coil domain-containing protein 74B isoform X2

    Conserved Domains (2) summary
    pfam14916
    Location:4783
    CCDC92; Coiled-coil domain of unknown function
    pfam14917
    Location:309423
    CCDC74_C; Coiled coil protein 74, C terminal
  7. XM_011512142.2XP_011510444.1  coiled-coil domain-containing protein 74B isoform X1

    Conserved Domains (1) summary
    pfam14917
    Location:365479
    CCDC74_C; Coiled coil protein 74, C terminal
  8. XM_011512147.1XP_011510449.1  coiled-coil domain-containing protein 74B isoform X8

    Related
    ENSP00000399683.1, ENST00000457413.1
    Conserved Domains (1) summary
    pfam14916
    Location:47142
    CCDC92; Coiled-coil domain of unknown function

RNA

  1. XR_001739036.1 RNA Sequence

  2. XR_001739034.1 RNA Sequence

  3. XR_001739033.1 RNA Sequence

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