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SCARF2 scavenger receptor class F member 2 [ Homo sapiens (human) ]

Gene ID: 91179, updated on 3-May-2025
Official Symbol
SCARF2provided by HGNC
Official Full Name
scavenger receptor class F member 2provided by HGNC
Primary source
HGNC:HGNC:19869
See related
Ensembl:ENSG00000244486 MIM:613619; AllianceGenome:HGNC:19869
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NSR1; SREC2; VDEGS; SREC-II; SRECRP-1
Summary
The protein encoded by this gene is similar to SCARF1/SREC-I, a scavenger receptor protein that mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). This protein has only little activity of internalizing modified low density lipoproteins (LDL), but it can interact with SCARF1 through its extracellular domain. The association of this protein with SCARF1 is suppressed by the presence of scavenger ligands. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 3.8), prostate (RPKM 3.4) and 24 other tissues See more
Orthologs
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See SCARF2 in Genome Data Viewer
Location:
22q11.21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (20424584..20437825, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (20828870..20842097, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20778874..20792112, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:20747551-20748540 Neighboring gene zinc finger protein 74 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62654 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62657 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:20764690-20764912 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62670 Neighboring gene VISTA enhancer hs1620 Neighboring gene RNA, U6 small nuclear 225, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr22:20783264-20783430 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:20784487-20785326 Neighboring gene uncharacterized LOC107985588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20795983-20796484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20796485-20796984 Neighboring gene kelch like family member 22 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62725 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_62734 Neighboring gene KLHL12 pseudogene 1

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scavenger receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in focal adhesion HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
scavenger receptor class F member 2
Names
scavenger receptor expressed by endothelial cells 2 protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031868.2 RefSeqGene

    Range
    5035..18276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_153334.7NP_699165.3  scavenger receptor class F member 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_699165.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF522196, BC009326
    Consensus CDS
    CCDS13779.2
    UniProtKB/Swiss-Prot
    E5RFB8, Q58A83, Q8IXF3, Q96GP6, Q9BW74
    Related
    ENSP00000485276.1, ENST00000623402.1
    Conserved Domains (1) summary
    PHA03247
    Location:534871
    PHA03247; large tegument protein UL36; Provisional
  2. NM_182895.5NP_878315.2  scavenger receptor class F member 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_878315.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment within the coding region, as compared to variant 1. The resulting isoform (2) lacks an internal region, as compared to isoform 1.
    Source sequence(s)
    AB024433, BC009326
    Consensus CDS
    CCDS46666.1
    UniProtKB/Swiss-Prot
    Q96GP6
    Related
    ENSP00000477564.2, ENST00000622235.5
    Conserved Domains (1) summary
    PHA03247
    Location:529866
    PHA03247; large tegument protein UL36; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    20424584..20437825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029065.3XP_016884554.1  scavenger receptor class F member 2 isoform X2

  2. XM_047441585.1XP_047297541.1  scavenger receptor class F member 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    20828870..20842097 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326108.1XP_054182083.1  scavenger receptor class F member 2 isoform X2

  2. XM_054326107.1XP_054182082.1  scavenger receptor class F member 2 isoform X1