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SCARF2 scavenger receptor class F member 2 [ Homo sapiens (human) ]

Gene ID: 91179, updated on 4-Jul-2021

Summary

Official Symbol
SCARF2provided by HGNC
Official Full Name
scavenger receptor class F member 2provided by HGNC
Primary source
HGNC:HGNC:19869
See related
Ensembl:ENSG00000244486 MIM:613619
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NSR1; SREC2; VDEGS; SREC-II; SRECRP-1
Summary
The protein encoded by this gene is similar to SCARF1/SREC-I, a scavenger receptor protein that mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). This protein has only little activity of internalizing modified low density lipoproteins (LDL), but it can interact with SCARF1 through its extracellular domain. The association of this protein with SCARF1 is suppressed by the presence of scavenger ligands. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 3.8), prostate (RPKM 3.4) and 24 other tissues See more
Orthologs
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Genomic context

See SCARF2 in Genome Data Viewer
Location:
22q11.21
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (20424584..20437825, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20778874..20792112, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 74 Neighboring gene VISTA enhancer hs1620 Neighboring gene RNA, U6 small nuclear 225, pseudogene Neighboring gene uncharacterized LOC107985588 Neighboring gene kelch like family member 12 pseudogene Neighboring gene kelch like family member 22

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in focal adhesion HDA PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
scavenger receptor class F member 2
Names
scavenger receptor expressed by endothelial cells 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031868.2 RefSeqGene

    Range
    5035..18276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_153334.7NP_699165.3  scavenger receptor class F member 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_699165.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF522196, BC009326
    Consensus CDS
    CCDS13779.2
    UniProtKB/Swiss-Prot
    Q96GP6
    UniProtKB/TrEMBL
    A0A096LNX8
    Related
    ENSP00000485276.1, ENST00000623402.1
    Conserved Domains (1) summary
    PHA03247
    Location:534871
    PHA03247; large tegument protein UL36; Provisional
  2. NM_182895.5NP_878315.2  scavenger receptor class F member 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_878315.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment within the coding region, as compared to variant 1. The resulting isoform (2) lacks an internal region, as compared to isoform 1.
    Source sequence(s)
    AB024433, BC009326
    Consensus CDS
    CCDS46666.1
    UniProtKB/Swiss-Prot
    Q96GP6
    Related
    ENSP00000477564.2, ENST00000622235.5
    Conserved Domains (1) summary
    PHA03247
    Location:529866
    PHA03247; large tegument protein UL36; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    20424584..20437825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029065.2XP_016884554.1  scavenger receptor class F member 2 isoform X1

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