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USP10 ubiquitin specific peptidase 10 [ Homo sapiens (human) ]

Gene ID: 9100, updated on 9-Dec-2024

Summary

Official Symbol
USP10provided by HGNC
Official Full Name
ubiquitin specific peptidase 10provided by HGNC
Primary source
HGNC:HGNC:12608
See related
Ensembl:ENSG00000103194 MIM:609818; AllianceGenome:HGNC:12608
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBPO
Summary
Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in placenta (RPKM 15.2), lymph node (RPKM 13.4) and 25 other tissues See more
Orthologs
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Genomic context

See USP10 in Genome Data Viewer
Location:
16q24.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (84700000..84779922)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (90766262..90846179)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (84733606..84813528)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84605929-84606461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84617304-84617809 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11243 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84623933-84624432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84631141-84631642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84631643-84632142 Neighboring gene coactosin like F-actin binding protein 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84632885-84633706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11245 Neighboring gene Sharpr-MPRA regulatory region 4329 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84637045-84637609 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11249 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11251 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84647291-84647792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84647793-84648292 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7786 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7785 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84674539-84675097 Neighboring gene uncharacterized LOC105371376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7787 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7788 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11252 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84706085-84706586 Neighboring gene kelch like family member 36 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7791 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84745056-84745556 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84752587-84753087 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:84760363-84760863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11253 Neighboring gene Sharpr-MPRA regulatory region 11774 Neighboring gene uncharacterized LOC124903737 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84769037-84770002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84770003-84770968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11254 Neighboring gene Sharpr-MPRA regulatory region 6565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11255 Neighboring gene Sharpr-MPRA regulatory region 1784 Neighboring gene uncharacterized LOC105371378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84828009-84828510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84837954-84838454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84839622-84840200 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84840201-84840777 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84869778-84870346 Neighboring gene cysteine rich secretory protein LCCL domain containing 2 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:84878477-84879206 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:84879989-84880225 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:84884617-84885118 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:84913207-84914406 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84918435-84919058 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84919059-84919684 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84919685-84920308 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:84920309-84920933

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
EBI GWAS Catalog
Many sequence variants affecting diversity of adult human height.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC2621, KIAA0190

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA damage response, signal transduction by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to interleukin-1 IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoubiquitinated protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of stress granule assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein deubiquitination TAS
Traceable Author Statement
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in rescue of stalled ribosome IDA
Inferred from Direct Assay
more info
PubMed 
involved_in translesion synthesis TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 10
Names
deubiquitinating enzyme 10
ubiquitin specific protease 10
ubiquitin thioesterase 10
ubiquitin thiolesterase 10
ubiquitin-specific-processing protease 10
NP_001259004.1
NP_005144.2
XP_006721395.1
XP_011521745.1
XP_016879357.1
XP_047290832.1
XP_047290833.1
XP_047290834.1
XP_054170306.1
XP_054170307.1
XP_054170308.1
XP_054170309.1
XP_054170310.1
XP_054170311.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001272075.2NP_001259004.1  ubiquitin carboxyl-terminal hydrolase 10 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK299618, D80012, DB077919, GD151792
    Consensus CDS
    CCDS62004.1
    UniProtKB/TrEMBL
    A0A7G6J4N4
    Related
    ENSP00000457411.1, ENST00000570191.5
    Conserved Domains (1) summary
    pfam00443
    Location:419796
    UCH; Ubiquitin carboxyl-terminal hydrolase
  2. NM_005153.3NP_005144.2  ubiquitin carboxyl-terminal hydrolase 10 isoform 2

    See identical proteins and their annotated locations for NP_005144.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' end compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC009116, BC000263, BX537402
    Consensus CDS
    CCDS45537.1
    UniProtKB/Swiss-Prot
    B2RDJ8, B4DS84, Q14694, Q9BWG7, Q9NSL7
    Related
    ENSP00000219473.7, ENST00000219473.12
    Conserved Domains (2) summary
    cd02257
    Location:520793
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:414792
    UCH; Ubiquitin carboxyl-terminal hydrolase

RNA

  1. NR_073577.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks three alternate internal exons, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK293304, D80012, DB077919, GD151792
  2. NR_073578.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks four alternate internal exons, compared to variant 1. This variant is represented as non-coding due to the presence of two upstream ORFs that are predicted to interfere with translation of the longest ORF; translation of either of the upstream ORFs renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    CR749515, D80012, GD151792
    Related
    ENST00000540269.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    84700000..84779922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434877.1XP_047290833.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X2

  2. XM_017023868.2XP_016879357.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X2

    Conserved Domains (1) summary
    pfam00443
    Location:219596
    UCH; Ubiquitin carboxyl-terminal hydrolase
  3. XM_011523443.2XP_011521745.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X2

    See identical proteins and their annotated locations for XP_011521745.1

    Conserved Domains (1) summary
    pfam00443
    Location:219596
    UCH; Ubiquitin carboxyl-terminal hydrolase
  4. XM_047434878.1XP_047290834.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X2

  5. XM_006721332.2XP_006721395.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X2

    See identical proteins and their annotated locations for XP_006721395.1

    Conserved Domains (1) summary
    pfam00443
    Location:219596
    UCH; Ubiquitin carboxyl-terminal hydrolase
  6. XM_047434876.1XP_047290832.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    90766262..90846179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314333.1XP_054170308.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X2

  2. XM_054314334.1XP_054170309.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X2

  3. XM_054314335.1XP_054170310.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X2

  4. XM_054314336.1XP_054170311.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X2

  5. XM_054314332.1XP_054170307.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X2

  6. XM_054314331.1XP_054170306.1  ubiquitin carboxyl-terminal hydrolase 10 isoform X1