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CD1B CD1b molecule [ Homo sapiens (human) ]

Gene ID: 910, updated on 23-Nov-2021

Summary

Official Symbol
CD1Bprovided by HGNC
Official Full Name
CD1b moleculeprovided by HGNC
Primary source
HGNC:HGNC:1635
See related
Ensembl:ENSG00000158485 MIM:188360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
R1; CD1; CD1A
Summary
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See CD1B in Genome Data Viewer
Location:
1q23.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (158285406..158331531, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (158297745..158301321, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CD1a molecule Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 5 Neighboring gene CD1c molecule Neighboring gene CD1e molecule Neighboring gene olfactory receptor family 10 subfamily T member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC125990, MGC125991

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables endogenous lipid antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables exogenous lipid antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lipopeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
located_in cell surface HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
T-cell surface glycoprotein CD1b
Names
CD1B antigen, b polypeptide
cortical thymocyte antigen CD1B
differentiation antigen CD1-alpha-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001764.3NP_001755.1  T-cell surface glycoprotein CD1b precursor

    See identical proteins and their annotated locations for NP_001755.1

    Status: REVIEWED

    Source sequence(s)
    AI336342, BC104217, CD687240
    Consensus CDS
    CCDS1176.1
    UniProtKB/Swiss-Prot
    P29016
    Related
    ENSP00000357150.3, ENST00000368168.4
    Conserved Domains (2) summary
    cd07698
    Location:203295
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:19198
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    158285406..158331531 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002785.2XP_016858274.1  T-cell surface glycoprotein CD1b isoform X3

  2. XM_017002784.2XP_016858273.1  T-cell surface glycoprotein CD1b isoform X2

  3. XM_017002786.2XP_016858275.1  T-cell surface glycoprotein CD1b isoform X4

  4. XM_011510119.3XP_011508421.1  T-cell surface glycoprotein CD1b isoform X1

    See identical proteins and their annotated locations for XP_011508421.1

    UniProtKB/Swiss-Prot
    P29016
    Related
    ENSP00000395161.1, ENST00000451207.5
    Conserved Domains (2) summary
    cl08246
    Location:19198
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cl11960
    Location:203257
    Ig; Immunoglobulin domain
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