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TMSB4Y thymosin beta 4 Y-linked [ Homo sapiens (human) ]

Gene ID: 9087, updated on 11-Sep-2019

Summary

Official Symbol
TMSB4Yprovided by HGNC
Official Full Name
thymosin beta 4 Y-linkedprovided by HGNC
Primary source
HGNC:HGNC:11882
See related
Ensembl:ENSG00000154620 MIM:400017
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TB4Y
Summary
This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X escapes X inactivation and encodes an actin sequestering protein. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 2.3), prostate (RPKM 2.2) and 19 other tissues See more

Genomic context

See TMSB4Y in Genome Data Viewer
Location:
Yq11.221
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (13703899..13706024)
105 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (15815447..15817904)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene ubiquitously transcribed tetratricopeptide repeat containing, Y-linked Neighboring gene proteasome subunit alpha 6 pseudogene 1 Neighboring gene microRNA 12120 Neighboring gene PC4 and SFRS1 interacting protein 1 pseudogene 2 Neighboring gene anosmin 2, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC26307

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin monomer binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament organization IEA
Inferred from Electronic Annotation
more info
 
regulation of actin polymerization or depolymerization TAS
Traceable Author Statement
more info
PubMed 
regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequestering of actin monomers IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
thymosin beta-4, Y-chromosomal
Names
thymosin beta-4, Y isoform
thymosin, beta 4, Y chromosome

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004202.3NP_004193.1  thymosin beta-4, Y-chromosomal

    See identical proteins and their annotated locations for NP_004193.1

    Status: REVIEWED

    Source sequence(s)
    BC022482, BC119763
    Consensus CDS
    CCDS14786.1
    UniProtKB/Swiss-Prot
    O14604
    Related
    ENSP00000284856.3, ENST00000284856.4
    Conserved Domains (1) summary
    pfam01290
    Location:341
    Thymosin; Thymosin beta-4 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

    Range
    13703899..13706024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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