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BPY2 basic charge Y-linked 2 [ Homo sapiens (human) ]

Gene ID: 9083, updated on 15-Sep-2022

Summary

Official Symbol
BPY2provided by HGNC
Official Full Name
basic charge Y-linked 2provided by HGNC
Primary source
HGNC:HGNC:13508
See related
Ensembl:ENSG00000183753 MIM:400013; AllianceGenome:HGNC:13508
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VCY2; BPY2A; VCY2A
Summary
This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. The encoded protein interacts with ubiquitin protein ligase E3A and may be involved in male germ cell development and male infertility. Three nearly identical copies of this gene exist on chromosome Y; two copies are part of a palindromic region. This record represents the copy outside of the palidromic region. [provided by RefSeq, Jul 2008]
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Genomic context

See BPY2 in Genome Data Viewer
Location:
Yq11.223
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (22984263..23005465)
110 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (25843297..25864500, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (25130410..25151612)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 736 pseudogene 11, Y-linked Neighboring gene testis-specific transcript, Y-linked 4 Neighboring gene tripartite motif containing 60 pseudogene 8, Y-linked Neighboring gene zinc finger protein 736 pseudogene 3, Y-linked

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Spermatogenic failure, Y-linked, 2
MedGen: C1839071 OMIM: 415000 GeneReviews: Y Chromosome Infertility
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Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2012-08-22)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2012-08-22)

ClinGen Genome Curation Page

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables HECT domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in single fertilization TAS
Traceable Author Statement
more info
PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
testis-specific basic protein Y 2
Names
basic protein on Y chromosome 2
testis-specific basic protein on Y, 2
variable charge, Y-linked, 2
variably charged protein Y 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009862.1 RefSeqGene

    Range
    5001..26203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004678.3NP_004669.2  testis-specific basic protein Y 2

    See identical proteins and their annotated locations for NP_004669.2

    Status: REVIEWED

    Source sequence(s)
    AC006366, AF000980
    Consensus CDS
    CCDS14800.1
    UniProtKB/Swiss-Prot
    O14599
    Related
    ENSP00000329106.3, ENST00000331070.8

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

    Range
    22984263..23005465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060948.1 Alternate T2T-CHM13v2.0

    Range
    25843297..25864500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)