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SLC7A6 solute carrier family 7 member 6 [ Homo sapiens (human) ]

Gene ID: 9057, updated on 8-Oct-2018

Summary

Official Symbol
SLC7A6provided by HGNC
Official Full Name
solute carrier family 7 member 6provided by HGNC
Primary source
HGNC:HGNC:11064
See related
Ensembl:ENSG00000103064 MIM:605641; Vega:OTTHUMG00000176544
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAT3; LAT-2; y+LAT-2
Expression
Ubiquitous expression in fat (RPKM 11.5), lymph node (RPKM 10.0) and 24 other tissues See more
Orthologs

Genomic context

See SLC7A6 in Genome Data Viewer
Location:
16q22.1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (68264510..68301823)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (68298419..68335726)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene epithelial splicing regulatory protein 2 Neighboring gene microRNA 6773 Neighboring gene phospholipase A2 group XV Neighboring gene RNA, U6 small nuclear 1262, pseudogene Neighboring gene solute carrier family 7 member 6 opposite strand Neighboring gene protein arginine methyltransferase 7 Neighboring gene RNA, U4 small nuclear 30, pseudogene Neighboring gene sphingomyelin phosphodiesterase 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Human metabolic individuality in biomedical and pharmaceutical research.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0245, DKFZp686K15246

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amino acid transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
antiporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
L-alpha-amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular amino acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
protein-containing complex assembly TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
Y+L amino acid transporter 2
Names
amino acid permease
cationic amino acid transporter, y+ system
solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
solute carrier family 7 (cationic amino acid transporter, y+ system), member 6
y(+)L-type amino acid transporter 2
y+LAT2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076785.2NP_001070253.1  Y+L amino acid transporter 2

    See identical proteins and their annotated locations for NP_001070253.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC020978, D87432, DB107640, R48943
    Consensus CDS
    CCDS32470.1
    UniProtKB/Swiss-Prot
    Q92536
    UniProtKB/TrEMBL
    A0A024R719
    Related
    ENSP00000455064.1, OTTHUMP00000254480, ENST00000566454.5, OTTHUMT00000432466
    Conserved Domains (1) summary
    cl26159
    Location:17501
    AA_permease_2; Amino acid permease
  2. NM_003983.5NP_003974.3  Y+L amino acid transporter 2

    See identical proteins and their annotated locations for NP_003974.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC020978, BC028216, D87432, DB107640, R48943
    Consensus CDS
    CCDS32470.1
    UniProtKB/Swiss-Prot
    Q92536
    UniProtKB/TrEMBL
    A0A024R719
    Related
    ENSP00000219343.6, OTTHUMP00000254477, ENST00000219343.10, OTTHUMT00000432463
    Conserved Domains (1) summary
    cl26159
    Location:17501
    AA_permease_2; Amino acid permease

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    68264510..68301823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523438.2XP_011521740.1  Y+L amino acid transporter 2 isoform X1

    See identical proteins and their annotated locations for XP_011521740.1

    UniProtKB/Swiss-Prot
    Q92536
    UniProtKB/TrEMBL
    A0A024R719
    Conserved Domains (1) summary
    cl26159
    Location:17501
    AA_permease_2; Amino acid permease
  2. XM_024450486.1XP_024306254.1  Y+L amino acid transporter 2 isoform X1

    Conserved Domains (1) summary
    cl26159
    Location:17501
    AA_permease_2; Amino acid permease
  3. XM_011523433.1XP_011521735.1  Y+L amino acid transporter 2 isoform X1

    See identical proteins and their annotated locations for XP_011521735.1

    UniProtKB/Swiss-Prot
    Q92536
    UniProtKB/TrEMBL
    A0A024R719
    Conserved Domains (1) summary
    cl26159
    Location:17501
    AA_permease_2; Amino acid permease
  4. XM_011523434.1XP_011521736.1  Y+L amino acid transporter 2 isoform X1

    See identical proteins and their annotated locations for XP_011521736.1

    UniProtKB/Swiss-Prot
    Q92536
    UniProtKB/TrEMBL
    A0A024R719
    Conserved Domains (1) summary
    cl26159
    Location:17501
    AA_permease_2; Amino acid permease
  5. XM_024450487.1XP_024306255.1  Y+L amino acid transporter 2 isoform X1

    Conserved Domains (1) summary
    cl26159
    Location:17501
    AA_permease_2; Amino acid permease
  6. XM_024450488.1XP_024306256.1  Y+L amino acid transporter 2 isoform X1

    Conserved Domains (1) summary
    cl26159
    Location:17501
    AA_permease_2; Amino acid permease

RNA

  1. XR_243433.3 RNA Sequence

    Related
    ENST00000379152.7
  2. XR_001752019.2 RNA Sequence

  3. XR_001752020.1 RNA Sequence

    Related
    ENST00000648130.1
  4. XR_001752018.1 RNA Sequence

    Related
    OTTHUMT00000432464
  5. XR_002957851.1 RNA Sequence

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