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SLC7A6 solute carrier family 7 member 6 [ Homo sapiens (human) ]

Gene ID: 9057, updated on 3-Oct-2020

Summary

Official Symbol
SLC7A6provided by HGNC
Official Full Name
solute carrier family 7 member 6provided by HGNC
Primary source
HGNC:HGNC:11064
See related
Ensembl:ENSG00000103064 MIM:605641
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAT3; LAT-2; y+LAT-2
Expression
Ubiquitous expression in fat (RPKM 11.5), lymph node (RPKM 10.0) and 24 other tissues See more
Orthologs

Genomic context

See SLC7A6 in Genome Data Viewer
Location:
16q22.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (68264510..68301819)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (68298419..68335726)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene epithelial splicing regulatory protein 2 Neighboring gene microRNA 6773 Neighboring gene phospholipase A2 group XV Neighboring gene RNA, U6 small nuclear 1262, pseudogene Neighboring gene solute carrier family 7 member 6 opposite strand Neighboring gene protein arginine methyltransferase 7 Neighboring gene RNA, U4 small nuclear 30, pseudogene Neighboring gene sphingomyelin phosphodiesterase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
An atlas of genetic influences on human blood metabolites.
GeneReviews: Not available
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available
Human metabolic individuality in biomedical and pharmaceutical research.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0245, DKFZp686K15246

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amino acid transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
antiporter activity IEA
Inferred from Electronic Annotation
more info
 
basic amino acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
L-alpha-amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amino acid transmembrane transport TAS
Traceable Author Statement
more info
PubMed 
amino acid transport TAS
Traceable Author Statement
more info
 
basic amino acid transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
ornithine transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
Y+L amino acid transporter 2
Names
amino acid permease
cationic amino acid transporter, y+ system
solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
solute carrier family 7 (cationic amino acid transporter, y+ system), member 6
y(+)L-type amino acid transporter 2
y+LAT2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076785.3NP_001070253.1  Y+L amino acid transporter 2

    See identical proteins and their annotated locations for NP_001070253.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC020978, D87432, DB107640
    Consensus CDS
    CCDS32470.1
    UniProtKB/Swiss-Prot
    Q92536
    UniProtKB/TrEMBL
    A0A024R719
    Related
    ENSP00000455064.1, ENST00000566454.5
    Conserved Domains (1) summary
    TIGR00911
    Location:17501
    2A0308; L-type amino acid transporter
  2. NM_003983.6NP_003974.3  Y+L amino acid transporter 2

    See identical proteins and their annotated locations for NP_003974.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC020978, BC028216, D87432, DB107640
    Consensus CDS
    CCDS32470.1
    UniProtKB/Swiss-Prot
    Q92536
    UniProtKB/TrEMBL
    A0A024R719
    Related
    ENSP00000219343.6, ENST00000219343.11
    Conserved Domains (1) summary
    TIGR00911
    Location:17501
    2A0308; L-type amino acid transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    68264510..68301819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523438.2XP_011521740.1  Y+L amino acid transporter 2 isoform X1

    See identical proteins and their annotated locations for XP_011521740.1

    UniProtKB/Swiss-Prot
    Q92536
    UniProtKB/TrEMBL
    A0A024R719
    Conserved Domains (1) summary
    TIGR00911
    Location:17501
    2A0308; L-type amino acid transporter
  2. XM_024450486.1XP_024306254.1  Y+L amino acid transporter 2 isoform X1

    Conserved Domains (1) summary
    TIGR00911
    Location:17501
    2A0308; L-type amino acid transporter
  3. XM_011523433.1XP_011521735.1  Y+L amino acid transporter 2 isoform X1

    See identical proteins and their annotated locations for XP_011521735.1

    UniProtKB/Swiss-Prot
    Q92536
    UniProtKB/TrEMBL
    A0A024R719
    Conserved Domains (1) summary
    TIGR00911
    Location:17501
    2A0308; L-type amino acid transporter
  4. XM_011523434.1XP_011521736.1  Y+L amino acid transporter 2 isoform X1

    See identical proteins and their annotated locations for XP_011521736.1

    UniProtKB/Swiss-Prot
    Q92536
    UniProtKB/TrEMBL
    A0A024R719
    Conserved Domains (1) summary
    TIGR00911
    Location:17501
    2A0308; L-type amino acid transporter
  5. XM_024450487.1XP_024306255.1  Y+L amino acid transporter 2 isoform X1

    Conserved Domains (1) summary
    TIGR00911
    Location:17501
    2A0308; L-type amino acid transporter
  6. XM_024450488.1XP_024306256.1  Y+L amino acid transporter 2 isoform X1

    Conserved Domains (1) summary
    TIGR00911
    Location:17501
    2A0308; L-type amino acid transporter

RNA

  1. XR_243433.3 RNA Sequence

    Related
    ENST00000379152.7
  2. XR_001752018.1 RNA Sequence

    Related
    ENST00000648130.1
  3. XR_002957851.1 RNA Sequence

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