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SAPCD2 suppressor APC domain containing 2 [ Homo sapiens (human) ]

Gene ID: 89958, updated on 7-Jun-2020

Summary

Official Symbol
SAPCD2provided by HGNC
Official Full Name
suppressor APC domain containing 2provided by HGNC
Primary source
HGNC:HGNC:28055
See related
Ensembl:ENSG00000186193 MIM:612057
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p42.3; C9orf140
Expression
Broad expression in brain (RPKM 4.5), colon (RPKM 2.8) and 17 other tissues See more
Orthologs

Genomic context

See SAPCD2 in Genome Data Viewer
Location:
9q34.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (137062127..137070559, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139956579..139965028, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene neural proliferation, differentiation and control 1 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 2 Neighboring gene uncharacterized LOC105376327 Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 Neighboring gene MAN1B1 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
establishment of mitotic spindle orientation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein localization to cell cortex IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of establishment of planar polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
symmetric cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
apical cortex IDA
Inferred from Direct Assay
more info
PubMed 
apical junction complex IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
suppressor APC domain-containing protein 2
Names
2010317E24Rik
TS/MDEP
protein C9orf140
tumor specificity and mitosis phase-dependent expression protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178448.4NP_848543.2  suppressor APC domain-containing protein 2

    See identical proteins and their annotated locations for NP_848543.2

    Status: VALIDATED

    Source sequence(s)
    BC042162, BC048267, BX332104
    Consensus CDS
    CCDS7027.2
    UniProtKB/Swiss-Prot
    Q86UD0
    Related
    ENSP00000386348.3, ENST00000409687.5
    Conserved Domains (1) summary
    pfam11414
    Location:225306
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    137062127..137070559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519180.3XP_011517482.1  suppressor APC domain-containing protein 2 isoform X1

    Conserved Domains (1) summary
    pfam11414
    Location:255336
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
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