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ATP6V0E1 ATPase H+ transporting V0 subunit e1 [ Homo sapiens (human) ]

Gene ID: 8992, updated on 22-Sep-2022


Official Symbol
ATP6V0E1provided by HGNC
Official Full Name
ATPase H+ transporting V0 subunit e1provided by HGNC
Primary source
See related
Ensembl:ENSG00000113732 MIM:603931; AllianceGenome:HGNC:863
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
M9.2; ATP6H; Vma21; Vma21p; ATP6V0E
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed pseudogenes have been found in dog, it is possible that the localization to chromosome 2 for this gene by radiation hybrid mapping is representing a pseudogene. Genomic mapping puts the chromosomal location on 5q35.3. [provided by RefSeq, Jul 2008]
Ubiquitous expression in thyroid (RPKM 131.7), kidney (RPKM 118.1) and 25 other tissues See more
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Genomic context

See ATP6V0E1 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (172983771..173035445)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (173523874..173575550)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (172410774..172462448)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RPL26L1 antisense RNA 1 Neighboring gene ribosomal protein L26 like 1 Neighboring gene Sharpr-MPRA regulatory region 5956 Neighboring gene inorganic pyrophosphatase 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 12761 Neighboring gene Sharpr-MPRA regulatory region 4768 Neighboring gene small nucleolar RNA, H/ACA box 74B Neighboring gene CREB3 regulatory factor Neighboring gene CDC42 pseudogene 5 Neighboring gene BCL2 interacting protein 1

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATPase-coupled ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
enables protein binding IPI
Inferred from Physical Interaction
more info
enables proton-transporting ATPase activity, rotational mechanism IGI
Inferred from Genetic Interaction
more info
Process Evidence Code Pubs
involved_in proton transmembrane transport IGI
Inferred from Genetic Interaction
more info
involved_in regulation of macroautophagy NAS
Non-traceable Author Statement
more info
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
involved_in vacuolar acidification ISS
Inferred from Sequence or Structural Similarity
more info
Component Evidence Code Pubs
located_in endosome membrane TAS
Traceable Author Statement
more info
located_in lysosomal membrane TAS
Traceable Author Statement
more info
located_in phagocytic vesicle membrane TAS
Traceable Author Statement
more info
part_of proton-transporting V-type ATPase, V0 domain IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
V-type proton ATPase subunit e 1
ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
H(+)-transporting two-sector ATPase, subunit H
V-ATPase 9.2 kDa membrane accessory protein
V-ATPase H subunit
V-ATPase M9.2 subunit
V-ATPase subunit e 1
vacuolar ATP synthase subunit H
vacuolar proton pump H subunit
vacuolar proton pump subunit e 1
vacuolar proton-ATPase subunit M9.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003945.4NP_003936.1  V-type proton ATPase subunit e 1

    See identical proteins and their annotated locations for NP_003936.1

    Status: REVIEWED

    Source sequence(s)
    AC008429, AI198465, BF691381, Y15286
    Consensus CDS
    O15342, Q6IBE8
    ENSP00000429690.1, ENST00000519374.6
    Conserved Domains (1) summary
    ATP_synt_H; ATP synthase subunit H

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060929.1 Alternate T2T-CHM13v2.0

    GenBank, FASTA, Sequence Viewer (Graphics)