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TPD52L3 TPD52 like 3 [ Homo sapiens (human) ]

Gene ID: 89882, updated on 24-Nov-2020

Summary

Official Symbol
TPD52L3provided by HGNC
Official Full Name
TPD52 like 3provided by HGNC
Primary source
HGNC:HGNC:23382
See related
Ensembl:ENSG00000170777 MIM:617567
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D55; hD55; TPD55; NYDSP25
Summary
This gene encodes a member of the tumor protein D52-like family of proteins. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. The encoded protein may play a role in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Expression
Restricted expression toward testis (RPKM 52.1) See more
Orthologs
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Genomic context

See TPD52L3 in Genome Data Viewer
Location:
9p24.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (6328370..6331891)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (6328349..6331900)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987046 Neighboring gene interleukin 33 Neighboring gene selenoprotein T pseudogene 1 Neighboring gene ubiquitin like with PHD and ring finger domains 2 Neighboring gene RNA, 7SL, cytoplasmic 25, pseudogene Neighboring gene glycine decarboxylase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of periodontal pathogen colonization.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26757, MGC45374

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
tumor protein D55
Names
protein kinase NYD-SP25
testis development protein NYD-SP25
testis tissue sperm-binding protein Li 87P
tumor protein D52 like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001874.3NP_001001874.2  tumor protein D55 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL133480
    Consensus CDS
    CCDS34984.1
    Related
    ENSP00000318665.3, ENST00000314556.3
    Conserved Domains (1) summary
    pfam04201
    Location:6127
    TPD52; tumor protein D52 family
  2. NM_001001875.4NP_001001875.2  tumor protein D55 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal segment, as compared to variant 1. It encodes isoform 3 which has a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AL133480
    Consensus CDS
    CCDS34985.1
    Related
    ENSP00000370836.1, ENST00000381428.1
    Conserved Domains (1) summary
    pfam04201
    Location:6123
    TPD52; tumor protein D52 family
  3. NM_033516.6NP_277051.4  tumor protein D55 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL133480
    Consensus CDS
    CCDS34986.1
    Related
    ENSP00000341677.5, ENST00000344545.6
    Conserved Domains (1) summary
    pfam04201
    Location:6136
    TPD52; tumor protein D52 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    6328370..6331891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015280.2XP_016870769.1  tumor protein D55 isoform X1

    UniProtKB/Swiss-Prot
    Q96J77
    Conserved Domains (1) summary
    pfam04201
    Location:6123
    TPD52; tumor protein D52 family
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