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WNT3A Wnt family member 3A [ Homo sapiens (human) ]

Gene ID: 89780, updated on 3-May-2020

Summary

Official Symbol
WNT3Aprovided by HGNC
Official Full Name
Wnt family member 3Aprovided by HGNC
Primary source
HGNC:HGNC:15983
See related
Ensembl:ENSG00000154342 MIM:606359
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008]
Expression
Biased expression in placenta (RPKM 9.0), lung (RPKM 1.6) and 1 other tissue See more
Orthologs

Genomic context

See WNT3A in Genome Data Viewer
Location:
1q42.13
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (228006998..228067113)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228194723..228248972)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene septin 14 pseudogene 17 Neighboring gene capicua transcriptional repressor pseudogene 26 Neighboring gene long intergenic non-protein coding RNA 2809 Neighboring gene ADP ribosylation factor 1 Neighboring gene microRNA 3620

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119418, MGC119419, MGC119420

Gene Ontology Provided by GOA

Function Evidence Code Pubs
co-receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
COP9 signalosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway involved in forebrain neuroblast division IEA
Inferred from Electronic Annotation
more info
 
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation TAS
Traceable Author Statement
more info
PubMed 
axis elongation involved in somitogenesis IEA
Inferred from Electronic Annotation
more info
 
axon guidance IEA
Inferred from Electronic Annotation
more info
 
beta-catenin destruction complex disassembly TAS
Traceable Author Statement
more info
 
calcium ion transmembrane transport via low voltage-gated calcium channel IEA
Inferred from Electronic Annotation
more info
 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment IDA
Inferred from Direct Assay
more info
PubMed 
cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation in forebrain ISS
Inferred from Sequence or Structural Similarity
more info
 
cell proliferation in midbrain TAS
Traceable Author Statement
more info
PubMed 
cellular protein localization IEA
Inferred from Electronic Annotation
more info
 
cellular response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
dorsal/ventral neural tube patterning IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
heart looping IEA
Inferred from Electronic Annotation
more info
 
hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
inner ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
mammary gland development IEA
Inferred from Electronic Annotation
more info
 
modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
negative regulation of axon extension involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 
negative regulation of dopaminergic neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of heart induction by canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
paraxial mesodermal cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
platelet aggregation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cardiac muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell-cell adhesion mediated by cadherin IEA
Inferred from Electronic Annotation
more info
 
positive regulation of collateral sprouting in absence of injury IEA
Inferred from Electronic Annotation
more info
 
positive regulation of core promoter binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dermatome development IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of hepatocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mesodermal cell fate specification IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
post-anal tail morphogenesis IEA
Inferred from Electronic Annotation
more info
 
postsynapse to nucleus signaling pathway IEA
Inferred from Electronic Annotation
more info
 
presynapse assembly TAS
Traceable Author Statement
more info
PubMed 
regulation of microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
regulation of presynapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of presynapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synapse organization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
secondary palate development IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
somatic stem cell division IEA
Inferred from Electronic Annotation
more info
 
spinal cord association neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle recycling TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi lumen TAS
Traceable Author Statement
more info
 
Wnt-Frizzled-LRP5/6 complex IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
early endosome membrane TAS
Traceable Author Statement
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein Wnt-3a
Names
wingless-type MMTV integration site family, member 3A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033131.4NP_149122.1  protein Wnt-3a precursor

    See identical proteins and their annotated locations for NP_149122.1

    Status: REVIEWED

    Source sequence(s)
    AB060284, AK056278, AL136379, CA437424, DA742143
    Consensus CDS
    CCDS1564.1
    UniProtKB/Swiss-Prot
    P56704
    Related
    ENSP00000284523.1, ENST00000284523.2
    Conserved Domains (1) summary
    smart00097
    Location:44352
    WNT1; found in Wnt-1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    228006998..228067113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544319.3XP_011542621.1  protein Wnt-3a isoform X1

    Conserved Domains (1) summary
    smart00097
    Location:44352
    WNT1; found in Wnt-1
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