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SERPINB12 serpin family B member 12 [ Homo sapiens (human) ]

Gene ID: 89777, updated on 24-Nov-2020

Summary

Official Symbol
SERPINB12provided by HGNC
Official Full Name
serpin family B member 12provided by HGNC
Primary source
HGNC:HGNC:14220
See related
Ensembl:ENSG00000166634 MIM:615662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
YUKOPIN
Expression
Restricted expression toward skin (RPKM 27.9) See more
Orthologs

Genomic context

See SERPINB12 in Genome Data Viewer
Location:
18q21.33
Exon count:
12
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (63519164..63569329)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (61223393..61234336)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene VPS4B-SERPINB5 intergenic CAGE-defined mid-level expression enhancer Neighboring gene serpin family B member 5 Neighboring gene ATP synthase membrane subunit c locus 1 pseudogene 6 Neighboring gene serpin family B member 13 Neighboring gene serpin family B member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119247, MGC119248

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding NAS
Non-traceable Author Statement
more info
PubMed 
serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type endopeptidase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
serpin B12
Names
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 12
serpin peptidase inhibitor, clade B (ovalbumin), member 12

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001307928.2NP_001294857.1  serpin B12 isoform 1

    See identical proteins and their annotated locations for NP_001294857.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC090307
    Consensus CDS
    CCDS77194.1
    UniProtKB/Swiss-Prot
    Q96P63
    Conserved Domains (1) summary
    cd02059
    Location:4425
    ovalbumin_like; The ovalbumin_like group of serpins contains ovalbumin, the squamous cell carcinoma antigen 1 (SCCA1) and other closely related serpins of clade B of the serpin superfamily. Ovalbumin, the major protein component of avian egg white, is a non-inhibitory ...
  2. NM_080474.2NP_536722.1  serpin B12 isoform 2

    See identical proteins and their annotated locations for NP_536722.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. The encoded idoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC090307, AF411191
    Consensus CDS
    CCDS11984.1
    UniProtKB/Swiss-Prot
    Q96P63
    Related
    ENSP00000269491.1, ENST00000269491.5
    Conserved Domains (1) summary
    cd02059
    Location:4405
    ovalbumin_like; The ovalbumin_like group of serpins contains ovalbumin, the squamous cell carcinoma antigen 1 (SCCA1) and other closely related serpins of clade B of the serpin superfamily. Ovalbumin, the major protein component of avian egg white, is a non-inhibitory ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    63519164..63569329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266778.3XP_005266835.2  serpin B12 isoform X1

    Conserved Domains (1) summary
    cd02059
    Location:16437
    ovalbumin_like; The ovalbumin_like group of serpins contains ovalbumin, the squamous cell carcinoma antigen 1 (SCCA1) and other closely related serpins of clade B of the serpin superfamily. Ovalbumin, the major protein component of avian egg white, is a non-inhibitory ...
  2. XM_011526246.1XP_011524548.1  serpin B12 isoform X2

    Conserved Domains (1) summary
    cd02059
    Location:11432
    ovalbumin_like; The ovalbumin_like group of serpins contains ovalbumin, the squamous cell carcinoma antigen 1 (SCCA1) and other closely related serpins of clade B of the serpin superfamily. Ovalbumin, the major protein component of avian egg white, is a non-inhibitory ...
  3. XM_011526248.1XP_011524550.1  serpin B12 isoform X3

    See identical proteins and their annotated locations for XP_011524550.1

    UniProtKB/Swiss-Prot
    Q96P63
    Conserved Domains (1) summary
    cd02059
    Location:4425
    ovalbumin_like; The ovalbumin_like group of serpins contains ovalbumin, the squamous cell carcinoma antigen 1 (SCCA1) and other closely related serpins of clade B of the serpin superfamily. Ovalbumin, the major protein component of avian egg white, is a non-inhibitory ...
  4. XM_011526249.1XP_011524551.1  serpin B12 isoform X3

    See identical proteins and their annotated locations for XP_011524551.1

    UniProtKB/Swiss-Prot
    Q96P63
    Related
    ENSP00000372218.1, ENST00000382768.1
    Conserved Domains (1) summary
    cd02059
    Location:4425
    ovalbumin_like; The ovalbumin_like group of serpins contains ovalbumin, the squamous cell carcinoma antigen 1 (SCCA1) and other closely related serpins of clade B of the serpin superfamily. Ovalbumin, the major protein component of avian egg white, is a non-inhibitory ...
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