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HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 [ Homo sapiens (human) ]

Gene ID: 8916, updated on 12-Aug-2022

Summary

Official Symbol
HERC3provided by HGNC
Official Full Name
HECT and RLD domain containing E3 ubiquitin protein ligase 3provided by HGNC
Primary source
HGNC:HGNC:4876
See related
Ensembl:ENSG00000138641 Ensembl:ENSG00000287542 MIM:605200; AllianceGenome:HGNC:4876
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Expression
Ubiquitous expression in prostate (RPKM 6.4), thyroid (RPKM 5.6) and 25 other tissues See more
Orthologs
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Genomic context

See HERC3 in Genome Data Viewer
Location:
4q22.1
Exon count:
28
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (88523843..88708539)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (91855488..92040225)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (89444994..89629690)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene CD53 molecule pseudogene Neighboring gene nuclear receptor coactivator 4 pseudogene 2 Neighboring gene PIGY divergent transcript Neighboring gene PIGY upstream open reading frame Neighboring gene phosphatidylinositol glycan anchor biosynthesis class Y Neighboring gene RN7SK pseudogene 244 Neighboring gene RNA, U6 small nuclear 33, pseudogene Neighboring gene FAM13A antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 7691 Neighboring gene nucleosome assembly protein 1 like 5 Neighboring gene family with sequence similarity 13 member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0032

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable E3 ubiquitin-protein ligase HERC3
Names
HECT domain and RCC1-like domain-containing protein 3
HECT-type E3 ubiquitin transferase HERC3
hect domain and RLD 3
NP_001258531.1
NP_001305434.1
NP_001362406.1
NP_001362407.1
NP_001362408.1
NP_001362409.1
NP_001362410.1
NP_001362411.1
NP_001362412.1
NP_055421.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271602.2NP_001258531.1  probable E3 ubiquitin-protein ligase HERC3 isoform 2

    See identical proteins and their annotated locations for NP_001258531.1

    Status: REVIEWED

    Source sequence(s)
    AC098582, AC108065
    UniProtKB/Swiss-Prot
    Q15034
    UniProtKB/TrEMBL
    B4DK41
    Conserved Domains (5) summary
    smart00119
    Location:608929
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    COG5184
    Location:134383
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:584930
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:90139
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:2150
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
  2. NM_001318505.2NP_001305434.1  probable E3 ubiquitin-protein ligase HERC3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AK289990, BC038960, CA427366, DA333248
    Consensus CDS
    CCDS82939.1
    UniProtKB/Swiss-Prot
    Q15034
    Related
    ENSP00000384005.1, ENST00000407637.5
    Conserved Domains (1) summary
    cl27697
    Location:2331
    RCC1; Regulator of chromosome condensation (RCC1) repeat
  3. NM_001375477.1NP_001362406.1  probable E3 ubiquitin-protein ligase HERC3 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC098582, AC108065
    Conserved Domains (2) summary
    COG5184
    Location:9237
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:576922
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  4. NM_001375478.1NP_001362407.1  probable E3 ubiquitin-protein ligase HERC3 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC098582, AC108065
    UniProtKB/TrEMBL
    H0Y8G9
    Conserved Domains (3) summary
    COG5184
    Location:2331
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:6941040
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:313377
    RCC1; Regulator of chromosome condensation (RCC1) repeat
  5. NM_001375479.1NP_001362408.1  probable E3 ubiquitin-protein ligase HERC3 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC098582, AC108065
    UniProtKB/TrEMBL
    H0Y8G9
    Conserved Domains (3) summary
    COG5184
    Location:2331
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:6941040
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:313377
    RCC1; Regulator of chromosome condensation (RCC1) repeat
  6. NM_001375480.1NP_001362409.1  probable E3 ubiquitin-protein ligase HERC3 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC098582, AC108065
    Conserved Domains (3) summary
    COG5184
    Location:2331
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:7011047
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:313377
    RCC1; Regulator of chromosome condensation (RCC1) repeat
  7. NM_001375481.1NP_001362410.1  probable E3 ubiquitin-protein ligase HERC3 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC098582, AC108065
    Conserved Domains (2) summary
    COG5184
    Location:4277
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:522868
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  8. NM_001375482.1NP_001362411.1  probable E3 ubiquitin-protein ligase HERC3 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC083829, AC098582, AC108065
    UniProtKB/TrEMBL
    H0Y8G9
    Conserved Domains (3) summary
    COG5184
    Location:2331
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:6941040
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:313377
    RCC1; Regulator of chromosome condensation (RCC1) repeat
  9. NM_001375483.1NP_001362412.1  probable E3 ubiquitin-protein ligase HERC3 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC083829, AC098582, AC108065
    UniProtKB/TrEMBL
    H0Y8G9
    Related
    ENSP00000421021.2, ENST00000512194.2
    Conserved Domains (3) summary
    COG5184
    Location:2331
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:6941040
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:313377
    RCC1; Regulator of chromosome condensation (RCC1) repeat
  10. NM_014606.3NP_055421.1  probable E3 ubiquitin-protein ligase HERC3 isoform 1

    See identical proteins and their annotated locations for NP_055421.1

    Status: REVIEWED

    Source sequence(s)
    AK289990, BE044624, D25215, DA333248
    Consensus CDS
    CCDS34028.1
    UniProtKB/Swiss-Prot
    Q15034, Q8IXX3
    Related
    ENSP00000385684.1, ENST00000402738.6
    Conserved Domains (3) summary
    COG5184
    Location:2331
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:7021048
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:313377
    RCC1; Regulator of chromosome condensation (RCC1) repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    88523843..88708539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    91855488..92040225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)