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HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 [ Homo sapiens (human) ]

Gene ID: 8916, updated on 1-Jun-2020

Summary

Official Symbol
HERC3provided by HGNC
Official Full Name
HECT and RLD domain containing E3 ubiquitin protein ligase 3provided by HGNC
Primary source
HGNC:HGNC:4876
See related
Ensembl:ENSG00000138641 Ensembl:ENSG00000287542 MIM:605200
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Expression
Ubiquitous expression in prostate (RPKM 6.4), thyroid (RPKM 5.6) and 25 other tissues See more
Orthologs

Genomic context

See HERC3 in Genome Data Viewer
Location:
4q22.1
Exon count:
31
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (88523843..88709303)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (89513574..89629693)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene CD53 molecule pseudogene Neighboring gene nuclear receptor coactivator 4 pseudogene 2 Neighboring gene PIGY divergent transcript Neighboring gene PIGY upstream reading frame Neighboring gene phosphatidylinositol glycan anchor biosynthesis class Y Neighboring gene RN7SK pseudogene 244 Neighboring gene RNA, U6 small nuclear 33, pseudogene Neighboring gene FAM13A antisense RNA 1 Neighboring gene nucleosome assembly protein 1 like 5 Neighboring gene HNF1 motif-containing MPRA enhancer 87 Neighboring gene family with sequence similarity 13 member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0032

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
probable E3 ubiquitin-protein ligase HERC3
Names
HECT domain and RCC1-like domain-containing protein 3
HECT-type E3 ubiquitin transferase HERC3
hect domain and RLD 3
NP_001258531.1
NP_001305434.1
NP_001362406.1
NP_001362407.1
NP_001362408.1
NP_001362409.1
NP_001362410.1
NP_001362411.1
NP_001362412.1
NP_055421.1
XP_005263384.1
XP_005263387.1
XP_005263388.1
XP_005263389.1
XP_011530699.1
XP_016864297.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271602.2NP_001258531.1  probable E3 ubiquitin-protein ligase HERC3 isoform 2

    See identical proteins and their annotated locations for NP_001258531.1

    Status: REVIEWED

    Source sequence(s)
    AC098582, AC108065
    UniProtKB/Swiss-Prot
    Q15034
    UniProtKB/TrEMBL
    B4DK41
    Conserved Domains (5) summary
    smart00119
    Location:608929
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    COG5184
    Location:134383
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:584930
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:90139
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:2150
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
  2. NM_001318505.2NP_001305434.1  probable E3 ubiquitin-protein ligase HERC3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AK289990, BC038960, CA427366, DA333248
    Consensus CDS
    CCDS82939.1
    UniProtKB/Swiss-Prot
    Q15034
    Related
    ENSP00000384005.1, ENST00000407637.5
    Conserved Domains (1) summary
    cl27697
    Location:2331
    RCC1; Regulator of chromosome condensation (RCC1) repeat
  3. NM_001375477.1NP_001362406.1  probable E3 ubiquitin-protein ligase HERC3 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC098582, AC108065
  4. NM_001375478.1NP_001362407.1  probable E3 ubiquitin-protein ligase HERC3 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC098582, AC108065
  5. NM_001375479.1NP_001362408.1  probable E3 ubiquitin-protein ligase HERC3 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC098582, AC108065
  6. NM_001375480.1NP_001362409.1  probable E3 ubiquitin-protein ligase HERC3 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC098582, AC108065
  7. NM_001375481.1NP_001362410.1  probable E3 ubiquitin-protein ligase HERC3 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC098582, AC108065
  8. NM_001375482.1NP_001362411.1  probable E3 ubiquitin-protein ligase HERC3 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC083829, AC098582, AC108065
  9. NM_001375483.1NP_001362412.1  probable E3 ubiquitin-protein ligase HERC3 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC083829, AC098582, AC108065
    Related
    ENSP00000421021.2, ENST00000512194.2
  10. NM_014606.3NP_055421.1  probable E3 ubiquitin-protein ligase HERC3 isoform 1

    See identical proteins and their annotated locations for NP_055421.1

    Status: REVIEWED

    Source sequence(s)
    AK289990, BE044624, D25215, DA333248
    Consensus CDS
    CCDS34028.1
    UniProtKB/Swiss-Prot
    Q15034
    Related
    ENSP00000385684.1, ENST00000402738.6
    Conserved Domains (3) summary
    cd00078
    Location:7021048
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:313377
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    cl27697
    Location:2331
    RCC1; Regulator of chromosome condensation (RCC1) repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    88523843..88709303
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263327.3XP_005263384.1  probable E3 ubiquitin-protein ligase HERC3 isoform X1

    See identical proteins and their annotated locations for XP_005263384.1

    UniProtKB/Swiss-Prot
    Q15034
    Conserved Domains (3) summary
    cd00078
    Location:7021048
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:313377
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    cl27697
    Location:2331
    RCC1; Regulator of chromosome condensation (RCC1) repeat
  2. XM_005263330.4XP_005263387.1  probable E3 ubiquitin-protein ligase HERC3 isoform X3

    Conserved Domains (4) summary
    smart00119
    Location:676990
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:676991
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:208257
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:3665
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
  3. XM_005263331.2XP_005263388.1  probable E3 ubiquitin-protein ligase HERC3 isoform X5

    Conserved Domains (3) summary
    pfam00415
    Location:208257
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:3665
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    cl00077
    Location:702887
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  4. XM_005263332.4XP_005263389.1  probable E3 ubiquitin-protein ligase HERC3 isoform X6

    Conserved Domains (3) summary
    pfam00415
    Location:208257
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:3665
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    cl00077
    Location:702886
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  5. XM_017008808.1XP_016864297.1  probable E3 ubiquitin-protein ligase HERC3 isoform X7

  6. XM_011532397.2XP_011530699.1  probable E3 ubiquitin-protein ligase HERC3 isoform X8

    Conserved Domains (2) summary
    smart00119
    Location:170491
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:146492
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
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