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TRIM4 tripartite motif containing 4 [ Homo sapiens (human) ]

Gene ID: 89122, updated on 5-Jan-2022

Summary

Official Symbol
TRIM4provided by HGNC
Official Full Name
tripartite motif containing 4provided by HGNC
Primary source
HGNC:HGNC:16275
See related
Ensembl:ENSG00000146833
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF87
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternatively spliced transcript variants that encode different isoforms have been described.[provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in ovary (RPKM 16.5), thyroid (RPKM 12.9) and 25 other tissues See more
Orthologs
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Genomic context

See TRIM4 in Genome Data Viewer
Location:
7q22.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (99890403..99919530, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99488026..99517153, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 3 subfamily A member 52, pseudogene Neighboring gene olfactory receptor family 2 subfamily AE member 1 Neighboring gene uncharacterized LOC101927610 Neighboring gene gap junction protein gamma 3 Neighboring gene alpha-2-glycoprotein 1, zinc-binding

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
EBI GWAS Catalog
Human metabolic individuality in biomedical and pharmaceutical research.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity EXP
Inferred from Experiment
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response TAS
Traceable Author Statement
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM4
Names
RING finger protein 87
RING-type E3 ubiquitin transferase TRIM4
tripartite motif protein 4
NP_148977.2
NP_149082.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033017.4NP_148977.2  E3 ubiquitin-protein ligase TRIM4 isoform alpha

    See identical proteins and their annotated locations for NP_148977.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha) represents the longer transcript and encodes the longer isoform (alpha).
    Source sequence(s)
    AC011904
    Consensus CDS
    CCDS5679.1
    UniProtKB/Swiss-Prot
    Q9C037
    Related
    ENSP00000348216.2, ENST00000355947.6
    Conserved Domains (3) summary
    cd00021
    Location:86123
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam15227
    Location:1252
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd15809
    Location:305494
    SPRY_PRY_TRIM4; PRY/SPRY domain in tripartite motif-binding protein 4 (TRIM4), also known as RING finger protein 87 (RNF87)
  2. NM_033091.3NP_149082.1  E3 ubiquitin-protein ligase TRIM4 isoform beta

    See identical proteins and their annotated locations for NP_149082.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (beta) lacks an in-frame exon in the 5' coding region compared to variant alpha. The resulting protein (isoform beta) is shorter but has the same N- and C-termini compared to isoform alpha.
    Source sequence(s)
    AC011904
    Consensus CDS
    CCDS5678.1
    UniProtKB/Swiss-Prot
    Q9C037
    Related
    ENSP00000275736.4, ENST00000349062.7
    Conserved Domains (3) summary
    cd00021
    Location:86123
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam15227
    Location:1252
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd15809
    Location:279468
    SPRY_PRY_TRIM4; PRY/SPRY domain in tripartite motif-binding protein 4 (TRIM4), also known as RING finger protein 87 (RNF87)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    99890403..99919530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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