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esxO ESAT-6 like protein EsxO [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888956, updated on 6-Oct-2023

Summary

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Gene symbol
esxO
Gene description
ESAT-6 like protein EsxO
Locus tag
Rv2346c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
ES6_6; Mtb9.9E
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Genomic context

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Sequence:
NC_000962.3 (2625888..2626172, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene deoxyguanosine triphosphate triphosphohydrolase Neighboring gene transmembrane protein Neighboring gene ESAT-6 like protein EsxP Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mycobacterium tuberculosis EsxO (Rv2346c) promotes bacillary survival by inducing oxidative stress mediated genomic instability in macrophages. Mohanty S, et al. Tuberculosis (Edinb), 2016 Jan. PMID 26786654
  2. Rv2346c enhances mycobacterial survival within macrophages by inhibiting TNF-α and IL-6 production via the p38/miRNA/NF-κB pathway. Yao J, et al. Emerg Microbes Infect, 2018 Sep 19. PMID 30232332, Free PMC Article
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 were upregulated during Mycobacterium tuberculosis infection but downregulated by Rv2346c.
    Title: Rv2346c enhances mycobacterial survival within macrophages by inhibiting TNF-α and IL-6 production via the p38/miRNA/NF-κB pathway.
  2. Mycobacterium tuberculosis Rv2346c dampens antibacterial effector functions by inducing oxidative stress mediated genomic instability in infected macrophages.
    Title: Mycobacterium tuberculosis EsxO (Rv2346c) promotes bacillary survival by inducing oxidative stress mediated genomic instability in macrophages.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
ESAT-6 like protein EsxO

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2625888..2626172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216862.1 ESAT-6 like protein EsxO [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216862.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M7X8
    Conserved Domains (1) summary
    pfam06013
    Location:3 → 86
    WXG100; Proteins of 100 residues with WXG
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WNI7.1

Gene LinkOut

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Molecular Biology Databases