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aroG phospho-2-dehydro-3-deoxyheptonate aldolase AroG [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888309, updated on 11-Dec-2020
Gene symbol
aroG
Gene description
phospho-2-dehydro-3-deoxyheptonate aldolase AroG
Locus tag
Rv2178c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Sequence:
NC_000962.3 (2440332..2441720, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein kinase PknL Neighboring gene transposase Neighboring gene 3'-5' exoribonuclease Neighboring gene integral membrane protein

Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Three sites and you are out: ternary synergistic allostery controls aromatic amino acid biosynthesis in Mycobacterium tuberculosis. Blackmore NJ, et al. J Mol Biol, 2013 May 13. PMID 23274137
  2. The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes. Webby CJ, et al. J Mol Biol, 2005 Dec 9. PMID 16288916
  3. DAHP synthase from Mycobacterium tuberculosis H37Rv: cloning, expression, and purification of functional enzyme. Rizzi C, et al. Protein Expr Purif, 2005 Mar. PMID 15721768
  4. Remote Control by Inter-Enzyme Allostery: A Novel Paradigm for Regulation of the Shikimate Pathway. Munack S, et al. J Mol Biol, 2016 Mar 27. PMID 26776476
  5. A novel noncovalent complex of chorismate mutase and DAHP synthase from Mycobacterium tuberculosis: protein purification, crystallization and X-ray diffraction analysis. Okvist M, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009 Oct 1. PMID 19851019, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here, the authors show how DAHP synthase serves as an allosteric platform for feedback regulation of both enzymes, DAHP synthase and chorismate mutase.
    Title: Remote Control by Inter-Enzyme Allostery: A Novel Paradigm for Regulation of the Shikimate Pathway.
  2. Synergistic inhibition of aroG by a combination of tryptophan and phenylalanine can be significantly augmented by the addition of tyrosine.
    Title: Three sites and you are out: ternary synergistic allostery controls aromatic amino acid biosynthesis in Mycobacterium tuberculosis.
  3. MtCM was crystallized alone and in complex with MtDS. The crystals diffracted to 1.6 and 2.2 A resolution, respectively.
    Title: A novel noncovalent complex of chorismate mutase and DAHP synthase from Mycobacterium tuberculosis: protein purification, crystallization and X-ray diffraction analysis.
  4. The intracellular chorismate mutase of Mycobacterium tuberculosis (MtCM; Rv0948c) has poor activity and lacks prominent active-site residues. However, its catalytic efficiency increases >100-fold on addition of DAHP synthase (MtDS; Rv2178c).
    Title: Structure and function of a complex between chorismate mutase and DAHP synthase: efficiency boost for the junior partner.
  5. Cloning, expression, and purification of DAHP synthase.
    Title: DAHP synthase from Mycobacterium tuberculosis H37Rv: cloning, expression, and purification of functional enzyme.
  6. crystal structure in complex with phosphoenolpyruvate and Mn(2+) reveals a tightly associated dimer of (beta/alpha)(8) TIM barrels. The arrangement of residues in the active site, and the binding modes of PEP and Mn(2+) match those of the type I enzymes
    Title: The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes.
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Homology

Preferred Names
phospho-2-dehydro-3-deoxyheptonate aldolase AroG
NP_216694.1
  • DAHP synthetase, phenylalanine-repressible

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2440332..2441720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216694.1 phospho-2-dehydro-3-deoxyheptonate aldolase AroG [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216694.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    COG3200
    Location:27 → 462
    AroG2; 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase, class II [Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
3RZI_A.1
3RZI_B.1
O53512.1

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