aroG phospho-2-dehydro-3-deoxyheptonate aldolase AroG [Mycobacterium tuberculosis H37Rv] - Gene

Summary

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Gene symbol: aroG
Gene description: phospho-2-dehydro-3-deoxyheptonate aldolase AroG
Locus tag: Rv2178c
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage: Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:: NC_000962.3 (2440332..2441720, complement)

NC_000962.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_000962.3

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here, the authors show how DAHP synthase serves as an allosteric platform for feedback regulation of both enzymes, DAHP synthase and chorismate mutase.
Title: Remote Control by Inter-Enzyme Allostery: A Novel Paradigm for Regulation of the Shikimate Pathway.
Synergistic inhibition of aroG by a combination of tryptophan and phenylalanine can be significantly augmented by the addition of tyrosine.
Title: Three sites and you are out: ternary synergistic allostery controls aromatic amino acid biosynthesis in Mycobacterium tuberculosis.
MtCM was crystallized alone and in complex with MtDS. The crystals diffracted to 1.6 and 2.2 A resolution, respectively.
Title: A novel noncovalent complex of chorismate mutase and DAHP synthase from Mycobacterium tuberculosis: protein purification, crystallization and X-ray diffraction analysis.
The intracellular chorismate mutase of Mycobacterium tuberculosis (MtCM; Rv0948c) has poor activity and lacks prominent active-site residues. However, its catalytic efficiency increases >100-fold on addition of DAHP synthase (MtDS; Rv2178c).
Title: Structure and function of a complex between chorismate mutase and DAHP synthase: efficiency boost for the junior partner.
Cloning, expression, and purification of DAHP synthase.
Title: DAHP synthase from Mycobacterium tuberculosis H37Rv: cloning, expression, and purification of functional enzyme.
crystal structure in complex with phosphoenolpyruvate and Mn(2+) reveals a tightly associated dimer of (beta/alpha)(8) TIM barrels. The arrangement of residues in the active site, and the binding modes of PEP and Mn(2+) match those of the type I enzymes
Title: The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes.

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Pathways from PubChem

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General gene information

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Homology

Orthologs from OrthoDB

General protein information

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Preferred Names: phospho-2-dehydro-3-deoxyheptonate aldolase AroG

NP_216694.1

DAHP synthetase, phenylalanine-repressible

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000962.3 Reference assembly

Range

2440332..2441720 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_216694.1 phospho-2-dehydro-3-deoxyheptonate aldolase AroG [Mycobacterium tuberculosis H37Rv]

See identical proteins and their annotated locations for NP_216694.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A654ZWG0

Conserved Domains (1) summary

COG3200
Location:27 → 462

AroG2; 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase, class II [Amino acid transport and metabolism]