U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

alr alanine racemase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887634, updated on 27-Nov-2023

Summary

Go to the top of the page Help
Gene symbol
alr
Gene description
alanine racemase
Locus tag
Rv3423c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000962.3 (3840194..3841420, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene O-sialoglycoprotein endopeptidase Neighboring gene ribosomal-protein-alanine acetyltransferase RimI Neighboring gene hypothetical protein Neighboring gene tRNA threonylcarbamoyladenosine biosynthesis protein Neighboring gene hypothetical protein Neighboring gene PPE family protein PPE57

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance. Nakatani Y, et al. Antimicrob Agents Chemother, 2017 Dec. PMID 28971867, Free PMC Article
  2. Alanine racemase mutants of Mycobacterium tuberculosis require D-alanine for growth and are defective for survival in macrophages and mice. Awasthy D, et al. Microbiology (Reading), 2012 Feb. PMID 22075031
  3. The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site. LeMagueres P, et al. Biochemistry, 2005 Feb 8. PMID 15683232
  4. The alr-groEL1 operon in Mycobacterium tuberculosis: an interplay of multiple regulatory elements. Bhat AH, et al. Sci Rep, 2017 Mar 3. PMID 28256563, Free PMC Article
  5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The architecture of alanine racemase (alr)-chaperonin GroEL (groEL1) operon, conservation of the genetic context and a mosaic transcriptional profile displayed under various stress conditions convincingly suggest the involvement of this operon in stress adaptation.
    Title: The alr-groEL1 operon in Mycobacterium tuberculosis: an interplay of multiple regulatory elements.
  2. Alanine racemase mutations likely confer resistance to D-cycloserine.
    Title: Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance.
  3. The alr mutant was found to be defective for growth in macrophages.
    Title: Alanine racemase mutants of Mycobacterium tuberculosis require D-alanine for growth and are defective for survival in macrophages and mice.
  4. The report of the crystal structure of alanine racemase from Mycobacterium tuberculosis proposes the inclusion of conserved residues found at the entrance to the binding pocket as additional targets in ongoing structure-aided drug design efforts.
    Title: The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

General protein information

Go to the top of the page Help
Preferred Names
alanine racemase

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3840194..3841420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217940.1 alanine racemase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217940.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A0A1R3Y5U2, L0TFK3, P0A4X2, P0A4X3, P9WQA8, P9WQA9, Q50705, X2BNP3
    Conserved Domains (1) summary
    PRK00053
    Location:35 → 403
    alr; alanine racemase; Reviewed
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials