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CCKBR cholecystokinin B receptor [ Homo sapiens (human) ]

Gene ID: 887, updated on 24-Nov-2020

Summary

Official Symbol
CCKBRprovided by HGNC
Official Full Name
cholecystokinin B receptorprovided by HGNC
Primary source
HGNC:HGNC:1571
See related
Ensembl:ENSG00000110148 MIM:118445
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GASR; CCK-B; CCK2R
Summary
This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015]
Expression
Biased expression in stomach (RPKM 4.6), brain (RPKM 2.9) and 2 other tissues See more
Orthologs
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Genomic context

See CCKBR in Genome Data Viewer
Location:
11p15.4
Exon count:
5
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (6259838..6272127)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6280841..6293363)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene chromosome 11 open reading frame 42 Neighboring gene family with sequence similarity 160 member A2 Neighboring gene cyclic nucleotide gated channel subunit alpha 4 Neighboring gene uncharacterized LOC101927825 Neighboring gene caveolae associated protein 3 Neighboring gene sphingomyelin phosphodiesterase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol-3-kinase regulator activity TAS
Traceable Author Statement
more info
PubMed 
cholecystokinin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
gastrin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
peptide hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
type B gastrin/cholecystokinin receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cell surface receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
cholecystokinin signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
digestive tract development IEA
Inferred from Electronic Annotation
more info
 
gastric acid secretion IEA
Inferred from Electronic Annotation
more info
 
gland development IEA
Inferred from Electronic Annotation
more info
 
pH reduction IEA
Inferred from Electronic Annotation
more info
 
phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
regulation of phosphatidylinositol 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
gastrin/cholecystokinin type B receptor
Names
CCK-B receptor
CCK2 receptor
cholecystokinin-2 receptor
gastrin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030591.1 RefSeqGene

    Range
    5001..17454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001318029.2NP_001304958.1  gastrin/cholecystokinin type B receptor isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC022762, AC068733
    Consensus CDS
    CCDS81550.1
    UniProtKB/Swiss-Prot
    P32239
    UniProtKB/TrEMBL
    E9PIC8
    Related
    ENSP00000432079.1, ENST00000532715.5
    Conserved Domains (2) summary
    pfam00001
    Location:52306
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:60159
    7tm_4; Olfactory receptor
  2. NM_001363552.2NP_001350481.1  gastrin/cholecystokinin type B receptor isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC022762, AC068733, AF441129
    Consensus CDS
    CCDS86175.1
    Related
    ENSP00000435534.1, ENST00000525462.1
    Conserved Domains (2) summary
    cd14964
    Location:5781
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:55470
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. NM_176875.4NP_795344.1  gastrin/cholecystokinin type B receptor isoform 1

    See identical proteins and their annotated locations for NP_795344.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC022762, AC068733
    Consensus CDS
    CCDS7761.1
    UniProtKB/Swiss-Prot
    P32239
    Related
    ENSP00000335544.2, ENST00000334619.7
    Conserved Domains (2) summary
    cd14964
    Location:5781
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:55401
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    6259838..6272127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018516.1XP_016874005.1  gastrin/cholecystokinin type B receptor isoform X2

    UniProtKB/Swiss-Prot
    P32239
    Conserved Domains (2) summary
    pfam00001
    Location:5324
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:5177
    7tm_4; Olfactory receptor
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