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ripA peptidoglycan endopeptidase RipA [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886541, updated on 6-Oct-2023

Summary

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Gene symbol
ripA
Gene description
peptidoglycan endopeptidase RipA
Locus tag
Rv1477
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (1666990..1668408)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene iron-regulated aconitate hydratase Neighboring gene membrane protein Neighboring gene peptidoglycan endopeptidase RipB Neighboring gene transcriptional regulator MoxR1 Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mycobacterium tuberculosis RipA Dampens TLR4-Mediated Host Protective Response Using a Multi-Pronged Approach Involving Autophagy, Apoptosis, Metabolic Repurposing, and Immune Modulation. Shariq M, et al. Front Immunol, 2021. PMID 33746976, Free PMC Article
  2. Interaction of Mycobacterium tuberculosis Virulence Factor RipA with Chaperone MoxR1 Is Required for Transport through the TAT Secretion System. Bhuwan M, et al. mBio, 2016 Mar 1. PMID 26933057, Free PMC Article
  3. Peptidoglycan remodeling in Mycobacterium tuberculosis: comparison of structures and catalytic activities of RipA and RipB. Böth D, et al. J Mol Biol, 2011 Oct 14. PMID 21864539
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mycobacterium tuberculosis RipA Dampens TLR4-Mediated Host Protective Response Using a Multi-Pronged Approach Involving Autophagy, Apoptosis, Metabolic Repurposing, and Immune Modulation.
    Title: Mycobacterium tuberculosis RipA Dampens TLR4-Mediated Host Protective Response Using a Multi-Pronged Approach Involving Autophagy, Apoptosis, Metabolic Repurposing, and Immune Modulation.
  2. The authors identified MoxR1 as a protein-protein interaction partner of RipA and demonstrated chaperone activity of this protein. They show that MoxR1-mediated folding is critical for the secretion of RipA within the TAT system.
    Title: Interaction of Mycobacterium tuberculosis Virulence Factor RipA with Chaperone MoxR1 Is Required for Transport through the TAT Secretion System.
  3. Both RipA (Rv1477) and RipB (Rv1478) are able to bind peptidoglycan.
    Title: Peptidoglycan remodeling in Mycobacterium tuberculosis: comparison of structures and catalytic activities of RipA and RipB.
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General gene information

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Homology

General protein information

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Preferred Names
peptidoglycan endopeptidase RipA
NP_215993.1
  • peptidoglycan hydrolase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1666990..1668408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215993.1 peptidoglycan endopeptidase RipA [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215993.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M6L3
    Conserved Domains (1) summary
    NF033741
    Location:22 → 472
    NlpC_p60_RipA; NlpC/P60 family peptidoglycan endopeptidase RipA
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O53168.1

Gene LinkOut

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