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iniA isoniazid inductible protein IniA [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886510, updated on 6-Jun-2024

Summary

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Gene symbol
iniA
Gene description
isoniazid inductible protein IniA
Locus tag
Rv0342
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (410838..412760)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene isoniazid inducible protein IniB Neighboring gene iIsoniazid inductible protein IniC Neighboring gene lipoprotein LpqJ Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol. Colangeli R, et al. Mol Microbiol, 2005 Mar. PMID 15752203
  2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We have discovered that the iniA gene (Rv 0342) participates in the development of tolerance to both isoniazid and ethambutol; results suggest that iniA functions through an MDR-pump like mechanism
    Title: The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
isoniazid inductible protein IniA
NP_214856.1
  • Note that the iniA gene is also induced by the antibiotic ethambutol, an agent that inhibits cell wall biosynthesis by a mechanism that is distinct from isoniazid.

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    410838..412760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_214856.1 isoniazid inductible protein IniA [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_214856.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A9P2H547
    Conserved Domains (1) summary
    COG0699
    Location:1 → 611
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WJ99.1

Gene LinkOut

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Molecular Biology Databases