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embB arabinosyltransferase B [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886126, updated on 6-Oct-2023

Summary

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Gene symbol
embB
Gene description
arabinosyltransferase B
Locus tag
Rv3795
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (4246514..4249810)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene decaprenylphosphoryl-D-2-keto erythropentose reductase Neighboring gene arabinofuranosyltransferase Neighboring gene arabinosyltransferase C Neighboring gene arabinosyltransferase A Neighboring gene hypothetical protein Neighboring gene acyl-CoA dehydrogenase FadE35

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lack of association of novel mutation Asp397Gly in aftB gene with ethambutol resistance in clinical isolates of Mycobacterium tuberculosis. Giri A, et al. Tuberculosis (Edinb), 2019 Mar. PMID 30948176
  2. Mutations in the embB gene and their association with ethambutol resistance in multidrug-resistant Mycobacterium tuberculosis clinical isolates from Poland. Bakuła Z, et al. Biomed Res Int, 2013. PMID 24392447, Free PMC Article
  3. Correlation of the phenotypic ethambutol susceptibility of Mycobacterium tuberculosis with embB gene mutations in Korea. Park YK, et al. J Med Microbiol, 2012 Apr. PMID 22174373
  4. Characteristics of embB mutations in multidrug-resistant Mycobacterium tuberculosis isolates in Henan, China. Shi D, et al. J Antimicrob Chemother, 2011 Oct. PMID 21778195, Free PMC Article
  5. embCAB sequence variation among ethambutol-resistant Mycobacterium tuberculosis isolates without embB306 mutation. Plinke C, et al. J Antimicrob Chemother, 2010 Jul. PMID 20427375

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors conclude, though aftBAsp397Gly mutation is not associated with EMB resistance, this mutation may be a phylogenetic marker for the Beijing clade.
    Title: Lack of association of novel mutation Asp397Gly in aftB gene with ethambutol resistance in clinical isolates of Mycobacterium tuberculosis.
  2. association between embB mutations and resistance to Ethambutol(EMB): mutations in codon 306 were most common, found in both EMB-resistant (9) and EMB-susceptible (11) isolates
    Title: Mutations in the embB gene and their association with ethambutol resistance in multidrug-resistant Mycobacterium tuberculosis clinical isolates from Poland.
  3. The ethambutol resistance of M. TB strains isolated from patients in Xi'an is related to the mutation of embB gene.
    Title: [Correlation between ethambutol-resistance and embB gene mutation in Mycobacterium tuberculosis].
  4. embB mutation except for a few specific mutation types may be the main cause of EMB resistance.
    Title: Correlation of the phenotypic ethambutol susceptibility of Mycobacterium tuberculosis with embB gene mutations in Korea.
  5. results suggest embB mutations alone are not sufficient for the development of full resistance to ethambutol in M. tuberculosis and mutations other than embB are also needed.
    Title: Characteristics of embB mutations in multidrug-resistant Mycobacterium tuberculosis isolates in Henan, China.
  6. mutations in embB306, embB406 and embB497 were confirmed as hot spots for genomic variation in ethambutol-resistant clinical isolates
    Title: embCAB sequence variation among ethambutol-resistant Mycobacterium tuberculosis isolates without embB306 mutation.
  7. Drug resistance in M tuberculosis is due to mutations in relatively restricted regions of the genome: rpoB for RIF, katG and inhA for INH, embB for ethambutol, pncA for pyrazinamide, and so on.
    Title: Clinical efficacy of direct DNA sequencing analysis on sputum specimens for early detection of drug-resistant Mycobacterium tuberculosis in a clinical setting.
  8. A statistical significant association was found between the frequency of embB306 mutations and the multidrug resistant phenotype.
    Title: [Detection of mutations in codon 306 of the embB gene for molecular genetic characterization of clinical Mycobacterium tuberculosis strains].
  9. embB 306 mutations are sufficient to confer ethambutol resistance, and detection of these mutations should be considered in the development of rapid molecular tests
    Title: Mutations at embB codon 306 are an important molecular indicator of ethambutol resistance in Mycobacterium tuberculosis.
  10. The PknH-mediated increase in the transcription of embAB genes significantly alters resistance to ethambutol, a frontline antituberculosis drug known to target embAB genes.
    Title: Transcriptional control of the mycobacterial embCAB operon by PknH through a regulatory protein, EmbR, in vivo.
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Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
arabinosyltransferase B
NP_218312.1
  • EmbB (arabinosylindolylacetylinositol synthase)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    4246514..4249810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_218312.1 arabinosyltransferase B [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_218312.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024CBA5, A0A024CBD2, A0A024CBG6, A0A097KUD1, A0A0B5HFG7, A0A5B8GS92
    Conserved Domains (3) summary
    pfam04602
    Location:214 → 688
    Arabinose_trans; Mycobacterial cell wall arabinan synthesis protein
    pfam14896
    Location:720 → 1095
    Arabino_trans_C; EmbC C-terminal domain
    pfam17689
    Location:51 → 209
    Arabino_trans_N; Arabinosyltransferase concanavalin like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WNL7.1

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