U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

AKAP4 A-kinase anchoring protein 4 [ Homo sapiens (human) ]

Gene ID: 8852, updated on 11-Jun-2025
Official Symbol
AKAP4provided by HGNC
Official Full Name
A-kinase anchoring protein 4provided by HGNC
Primary source
HGNC:HGNC:374
See related
Ensembl:ENSG00000147081 MIM:300185; AllianceGenome:HGNC:374
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HI; p82; CT99; FSC1; PRKA4; AKAP-4; AKAP82; AKAP 82; hAKAP82
Summary
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 101.7) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See AKAP4 in Genome Data Viewer
Location:
Xp11.22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (50190777..50201007, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (49508429..49518665, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (49955420..49965658, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene chloride voltage-gated channel 5 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:49809130-49809715 Neighboring gene microRNA 502 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:49854497-49855696 Neighboring gene peptide YY 3 (pseudogene) Neighboring gene cyclin B3 Neighboring gene diacylglycerol kinase kappa Neighboring gene Sharpr-MPRA regulatory region 2913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:50212987-50213784

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase A binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase A binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein kinase A binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor protein serine/threonine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within establishment of localization in cell IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within establishment of protein localization IEA
Inferred from Electronic Annotation
more info
 
involved_in flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
 
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein localization IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in single fertilization TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within sperm flagellum assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 
part_of cAMP-dependent protein kinase complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
located_in motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in sperm end piece IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in sperm fibrous sheath IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in sperm fibrous sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm fibrous sheath IEA
Inferred from Electronic Annotation
more info
 
is_active_in sperm flagellum IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm head-tail coupling apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm midpiece IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in sperm principal piece IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in sperm principal piece IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm principal piece IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
A-kinase anchor protein 4
Names
A kinase (PRKA) anchor protein 4
A-kinase anchor protein 82 kDa
cancer/testis antigen 99
epididymis secretory sperm binding protein
major sperm fibrous sheath protein
protein kinase A anchoring protein 4
testis-specific gene HI

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012552.2 RefSeqGene

    Range
    5007..15237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003886.3NP_003877.2  A-kinase anchor protein 4 isoform 1

    See identical proteins and their annotated locations for NP_003877.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) includes an alternate 5' exon and encodes a longer isoform, as compared to variant 2.
    Source sequence(s)
    AC235789
    Consensus CDS
    CCDS14329.1
    UniProtKB/Swiss-Prot
    A0AV85, O60904, O95246, Q5JQC9, Q5JQD1, Q5JQD2, Q5JQD3
    UniProtKB/TrEMBL
    A0A384MQY7, A8K8U8
    Related
    ENSP00000351327.2, ENST00000358526.7
    Conserved Domains (1) summary
    smart00807
    Location:14854
    AKAP_110; A-kinase anchor protein 110 kDa
  2. NM_139289.2NP_647450.1  A-kinase anchor protein 4 isoform 2

    See identical proteins and their annotated locations for NP_647450.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate 5' exon, which lacks an ATG start codon, as compared to variant 1. This variant uses a downstream in-frame start codon, and thus encodes a shorter isoform.
    Source sequence(s)
    AC235789
    Consensus CDS
    CCDS14330.1
    UniProtKB/TrEMBL
    A8K8U8
    Related
    ENSP00000365232.3, ENST00000376064.7
    Conserved Domains (1) summary
    smart00807
    Location:5845
    AKAP_110; A-kinase anchor protein 110 kDa

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    50190777..50201007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    49508429..49518665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)