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CES2 carboxylesterase 2 [ Homo sapiens (human) ]

Gene ID: 8824, updated on 12-Oct-2019

Summary

Official Symbol
CES2provided by HGNC
Official Full Name
carboxylesterase 2provided by HGNC
Primary source
HGNC:HGNC:1864
See related
Ensembl:ENSG00000172831 MIM:605278
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
iCE; CE-2; PCE-2; CES2A1
Summary
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
Expression
Biased expression in duodenum (RPKM 209.7), small intestine (RPKM 176.0) and 8 other tissues See more
Orthologs

Genomic context

See CES2 in Genome Data Viewer
Location:
16q22.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (66934471..66945096)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (66968347..66978999)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RRAD, Ras related glycolysis inhibitor and calcium channel regulator Neighboring gene cytosolic iron-sulfur assembly component 2B Neighboring gene uncharacterized LOC107984881 Neighboring gene carboxylesterase 3 Neighboring gene Sharpr-MPRA regulatory region 4953

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
carboxylic ester hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
methyl indole-3-acetate esterase activity IEA
Inferred from Electronic Annotation
more info
 
methylumbelliferyl-acetate deacetylase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
catabolic process TAS
Traceable Author Statement
more info
PubMed 
prostaglandin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cocaine esterase
Names
carboxylesterase 2 (intestine, liver)
intestinal carboxylesterase; liver carboxylesterase-2
methylumbelliferyl-acetate deacetylase 2
NP_001352334.1
NP_001352335.1
NP_001352336.1
NP_001352337.1
NP_003860.3
NP_932327.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365405.1NP_001352334.1  cocaine esterase isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains the same exon structure as variant 1, but contains a shorter 5' UTR. This represents use of a different promoter, relative to variant 1. This promoter is the dominant promoter used in some tissue types.
    Source sequence(s)
    BC032095, BX538086
    Related
    ENSP00000317842.5, ENST00000317091.10
    Conserved Domains (1) summary
    pfam00135
    Location:30538
    COesterase; Carboxylesterase family
  2. NM_001365406.1NP_001352335.1  cocaine esterase isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, resulting in the use of a downtream start codon, relative to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK095522, BC032095, BX538086
    Conserved Domains (1) summary
    pfam00135
    Location:1445
    COesterase; Carboxylesterase family
  3. NM_001365407.1NP_001352336.1  cocaine esterase isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC009084
    Conserved Domains (1) summary
    pfam00135
    Location:1445
    COesterase; Carboxylesterase family
  4. NM_001365408.1NP_001352337.1  cocaine esterase isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC009084
    Conserved Domains (1) summary
    pfam00135
    Location:1429
    COesterase; Carboxylesterase family
  5. NM_003869.6NP_003860.3  cocaine esterase isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1) and contains a longer 5' UTR than some of the other variants. This variant represent use of an alternate promote that is used in some tissues, and uses a downstream start codon. The upstream start codon is not well conserved.
    Source sequence(s)
    BC032095, BX538086
    Consensus CDS
    CCDS10825.1
    Conserved Domains (1) summary
    pfam00135
    Location:30538
    COesterase; Carboxylesterase family
  6. NM_198061.3NP_932327.2  cocaine esterase isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a shorter 5' UTR and lacks an internal in-frame segment in the coding region, as compared to variant 1. The encoded isoform (2) is thus shorter than isoform 1.
    Source sequence(s)
    BC032095, BX538086
    Consensus CDS
    CCDS45507.1
    Related
    ENSP00000394452.2, ENST00000417689.6
    Conserved Domains (1) summary
    pfam00135
    Location:30522
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    66934471..66945096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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