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RGS9 regulator of G protein signaling 9 [ Homo sapiens (human) ]

Gene ID: 8787, updated on 1-Aug-2020

Summary

Official Symbol
RGS9provided by HGNC
Official Full Name
regulator of G protein signaling 9provided by HGNC
Primary source
HGNC:HGNC:10004
See related
Ensembl:ENSG00000108370 MIM:604067
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PERRS; RGS9L
Summary
This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Expression
Ubiquitous expression in brain (RPKM 1.6), lung (RPKM 1.2) and 24 other tissues See more
Orthologs

Genomic context

See RGS9 in Genome Data Viewer
Location:
17q24.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (65137370..65227703)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (63133456..63223821)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371864 Neighboring gene uncharacterized LOC100507002 Neighboring gene VISTA enhancer hs1517 Neighboring gene zinc finger protein 848, pseudogene Neighboring gene long intergenic non-protein coding RNA 2563 Neighboring gene axin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26458, MGC111763

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
GTPase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NMDA glutamate receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein folding TAS
Traceable Author Statement
more info
 
regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of calcium ion export across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 9
Names
regulator of G-protein signalling 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013021.2 RefSeqGene

    Range
    5033..95366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001081955.3NP_001075424.1  regulator of G-protein signaling 9 isoform 2

    See identical proteins and their annotated locations for NP_001075424.1

    Status: REVIEWED

    Source sequence(s)
    AK290535, CK300804, DC322215
    Consensus CDS
    CCDS45764.1
    UniProtKB/Swiss-Prot
    O75916
    Related
    ENSP00000396329.3, ENST00000449996.7
    Conserved Domains (3) summary
    smart00224
    Location:221280
    GGL; G protein gamma subunit-like motifs
    cd08739
    Location:292412
    RGS_RGS9; Regulator of G protein signaling (RGS) domain found in the RGS9 protein
    cd04450
    Location:22109
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  2. NM_001165933.2NP_001159405.1  regulator of G-protein signaling 9 isoform 3

    See identical proteins and their annotated locations for NP_001159405.1

    Status: REVIEWED

    Source sequence(s)
    AC015821, AC060771
    Related
    ENSP00000463410.1, ENST00000584234.5
    Conserved Domains (3) summary
    smart00224
    Location:221280
    GGL; G protein gamma subunit-like motifs
    cd08739
    Location:292412
    RGS_RGS9; Regulator of G protein signaling (RGS) domain found in the RGS9 protein
    cd04450
    Location:22109
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
  3. NM_003835.4NP_003826.2  regulator of G-protein signaling 9 isoform 1

    See identical proteins and their annotated locations for NP_003826.2

    Status: REVIEWED

    Source sequence(s)
    AF493933, AK289876, CK300804, DC322215
    Consensus CDS
    CCDS42373.1
    UniProtKB/Swiss-Prot
    O75916
    UniProtKB/TrEMBL
    A8K1G1
    Related
    ENSP00000262406.9, ENST00000262406.10
    Conserved Domains (3) summary
    smart00224
    Location:224283
    GGL; G protein gamma subunit-like motifs
    cd08739
    Location:295415
    RGS_RGS9; Regulator of G protein signaling (RGS) domain found in the RGS9 protein
    cd04450
    Location:22109
    DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    65137370..65227703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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