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NAPA NSF attachment protein alpha [ Homo sapiens (human) ]

Gene ID: 8775, updated on 4-Oct-2020

Summary

Official Symbol
NAPAprovided by HGNC
Official Full Name
NSF attachment protein alphaprovided by HGNC
Primary source
HGNC:HGNC:7641
See related
Ensembl:ENSG00000105402 MIM:603215
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNAPA
Summary
This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded protein plays a role in the completion of membrane fusion by mediating the interaction of N-ethylmaleimide-sensitive factor (NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE) complex, and stimulating the ATPase activity of NSF. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2011]
Expression
Ubiquitous expression in prostate (RPKM 53.4), adrenal (RPKM 52.5) and 25 other tissues See more
Orthologs

Genomic context

See NAPA in Genome Data Viewer
Location:
19q13.32-q13.33
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (47487637..47515091, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47990891..48018515, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 8 member A2 Neighboring gene kaptin, actin binding protein Neighboring gene NAPA antisense RNA 1 Neighboring gene zinc finger protein 541 Neighboring gene RNA, 7SL, cytoplasmic 322, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNARE binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
soluble NSF attachment protein activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
COPII vesicle coating TAS
Traceable Author Statement
more info
 
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
SNARE complex disassembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apical protein localization IEA
Inferred from Electronic Annotation
more info
 
brain development IEA
Inferred from Electronic Annotation
more info
 
intra-Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane fusion TAS
Traceable Author Statement
more info
PubMed 
neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ATPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic vesicle priming IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
 
synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle priming IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
postsynapse IEA
Inferred from Electronic Annotation
more info
 
presynapse IEA
Inferred from Electronic Annotation
more info
 
synaptobrevin 2-SNAP-25-syntaxin-1a complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
alpha-soluble NSF attachment protein
Names
N-ethylmaleimide-sensitive factor attachment protein, alpha
alpha-SNAP

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003827.4NP_003818.2  alpha-soluble NSF attachment protein

    See identical proteins and their annotated locations for NP_003818.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.
    Source sequence(s)
    AA542963, AK126519, BC028234
    Consensus CDS
    CCDS12702.1
    UniProtKB/Swiss-Prot
    P54920
    UniProtKB/TrEMBL
    A0A024R0R9
    Related
    ENSP00000263354.2, ENST00000263354.8
    Conserved Domains (1) summary
    pfam14938
    Location:19288
    SNAP; Soluble NSF attachment protein, SNAP

RNA

  1. NR_038456.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use the alternate splice site renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC073548, AW206113, U39412
  2. NR_038457.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two consecutive internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA542963, AC073548, AK126519, CX873074
    Related
    ENST00000594001.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    47487637..47515091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527437.1XP_011525739.1  alpha-soluble NSF attachment protein isoform X2

    Conserved Domains (2) summary
    cd15832
    Location:2183
    SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
    pfam14938
    Location:2184
    SNAP; Soluble NSF attachment protein, SNAP
  2. XM_011527436.1XP_011525738.1  alpha-soluble NSF attachment protein isoform X1

    Conserved Domains (2) summary
    cd15832
    Location:1237
    SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
    pfam14938
    Location:2238
    SNAP; Soluble NSF attachment protein, SNAP

RNA

  1. XR_002958377.1 RNA Sequence

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