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CDS2 CDP-diacylglycerol synthase 2 [ Homo sapiens (human) ]

Gene ID: 8760, updated on 1-Jun-2020

Summary

Official Symbol
CDS2provided by HGNC
Official Full Name
CDP-diacylglycerol synthase 2provided by HGNC
Primary source
HGNC:HGNC:1801
See related
Ensembl:ENSG00000101290 MIM:603549
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 21.0), heart (RPKM 9.4) and 24 other tissues See more
Orthologs

Genomic context

See CDS2 in Genome Data Viewer
Location:
20p12.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (5126844..5197887)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (5107407..5178533)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 230 Neighboring gene RNA, 5S ribosomal pseudogene 474 Neighboring gene PCNA antisense RNA 1 Neighboring gene proliferating cell nuclear antigen Neighboring gene meiotic recombination hotspot R Neighboring gene ubiquitin conjugating enzyme E2 D3 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12936, FLJ38111, FLJ41837

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidate cytidylyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidate cytidylyltransferase activity NAS
Non-traceable Author Statement
more info
PubMed 
phosphatidate cytidylyltransferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
CDP-diacylglycerol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
lipid droplet formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylglycerol biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane HDA PubMed 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
phosphatidate cytidylyltransferase 2
Names
CDP-DAG synthase 2
CDP-DG synthase 2
CDP-DG synthetase 2
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
CDP-diglyceride diphosphorylase 2
CDP-diglyceride pyrophosphorylase 2
CDP-diglyceride synthase 2
CDP-diglyceride synthetase 2
CDS 2
CTP:phosphatidate cytidylyltransferase 2
NP_003809.1
XP_006723723.1
XP_011527692.1
XP_024307784.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003818.4NP_003809.1  phosphatidate cytidylyltransferase 2

    See identical proteins and their annotated locations for NP_003809.1

    Status: REVIEWED

    Source sequence(s)
    AK315489, AL121755
    Consensus CDS
    CCDS13088.1
    UniProtKB/Swiss-Prot
    O95674
    Related
    ENSP00000419879.1, ENST00000460006.6
    Conserved Domains (1) summary
    cl21502
    Location:106425
    CTP_transf_1; Cytidylyltransferase family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    5126844..5197887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723660.2XP_006723723.1  phosphatidate cytidylyltransferase 2 isoform X1

    Conserved Domains (1) summary
    cl21502
    Location:106327
    CTP_transf_1; Cytidylyltransferase family
  2. XM_011529390.1XP_011527692.1  phosphatidate cytidylyltransferase 2 isoform X2

    Conserved Domains (1) summary
    cl21502
    Location:28347
    CTP_transf_1; Cytidylyltransferase family
  3. XM_024452016.1XP_024307784.1  phosphatidate cytidylyltransferase 2 isoform X2

    Conserved Domains (1) summary
    cl21502
    Location:28347
    CTP_transf_1; Cytidylyltransferase family
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