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ADAM21 ADAM metallopeptidase domain 21 [ Homo sapiens (human) ]

Gene ID: 8747, updated on 8-Jul-2021

Summary

Official Symbol
ADAM21provided by HGNC
Official Full Name
ADAM metallopeptidase domain 21provided by HGNC
Primary source
HGNC:HGNC:200
See related
Ensembl:ENSG00000139985 MIM:603713
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADAM31; ADAM 21
Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene expression is testis-specific. [provided by RefSeq, May 2011]
Expression
Biased expression in testis (RPKM 6.0) and brain (RPKM 0.2) See more
Orthologs
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Genomic context

See ADAM21 in Genome Data Viewer
Location:
14q24.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (70452174..70459905)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (70918891..70926622)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene SYNJ2BP-COX16 readthrough Neighboring gene RNA, U2 small nuclear 51, pseudogene Neighboring gene synaptojanin 2 binding protein Neighboring gene ADAM metallopeptidase domain 20 pseudogene 1 Neighboring gene RNA, U6 small nuclear 659, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC125389

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metallopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in male gonad development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in single fertilization TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in sperm head plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 21
Names
ADAM metallopeptidase domain 21, preproprotein
a disintegrin and metalloproteinase domain 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003813.4NP_003804.2  disintegrin and metalloproteinase domain-containing protein 21 preproprotein

    See identical proteins and their annotated locations for NP_003804.2

    Status: REVIEWED

    Source sequence(s)
    AA758110, AL357153, AL391223, DB035527
    Consensus CDS
    CCDS9804.1
    UniProtKB/Swiss-Prot
    Q9UKJ8
    Related
    ENSP00000474385.1, ENST00000603540.2
    Conserved Domains (5) summary
    smart00608
    Location:491627
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:208396
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:415487
    Disintegrin; Disintegrin
    pfam01421
    Location:209398
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:50158
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    70452174..70459905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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