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URI1 URI1 prefoldin like chaperone [ Homo sapiens (human) ]

Gene ID: 8725, updated on 27-Nov-2024

Summary

Official Symbol
URI1provided by HGNC
Official Full Name
URI1 prefoldin like chaperoneprovided by HGNC
Primary source
HGNC:HGNC:13236
See related
Ensembl:ENSG00000105176 MIM:603494; AllianceGenome:HGNC:13236
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RMP; URI; NNX3; C19orf2; PPP1R19
Summary
This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in thyroid (RPKM 23.9), testis (RPKM 18.7) and 25 other tissues See more
Orthologs
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Genomic context

See URI1 in Genome Data Viewer
Location:
19q12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (29923657..30016612)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (32444098..32537026)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (30414564..30507519)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14421 Neighboring gene cyclin E1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30348658-30349496 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30349497-30350334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10470 Neighboring gene Sharpr-MPRA regulatory region 11671 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30373138-30373673 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr19:30418723-30419224 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr19:30419225-30419724 Neighboring gene peptidylprolyl isomerase A pseudogene 58 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14424 Neighboring gene ribosomal protein L9 pseudogene 32 Neighboring gene VISTA enhancer hs381 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14425 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:30521325-30521824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14426 Neighboring gene TATA-box binding protein associated factor 9 pseudogene 3 Neighboring gene VISTA enhancer hs382 Neighboring gene uncharacterized LOC107985271 Neighboring gene VISTA enhancer hs721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14427

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ10575

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of RPAP3/R2TP/prefoldin-like complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein folding chaperone complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
unconventional prefoldin RPB5 interactor 1
Names
RNA polymerase II subunit 5-mediating protein
RPB5-mediating protein
protein phosphatase 1, regulatory subunit 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047095.1 RefSeqGene

    Range
    23596..97969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001252641.2NP_001239570.1  unconventional prefoldin RPB5 interactor 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) is shorter and has distinct N- and C-termini, compared to isoform a.
    Source sequence(s)
    AA678820, AW003989, AW954529, BC026184, BG742069
    Consensus CDS
    CCDS58658.1
    UniProtKB/TrEMBL
    Q6NX55
    Related
    ENSP00000353817.4, ENST00000360605.8
    Conserved Domains (1) summary
    cl09111
    Location:27129
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  2. NM_003796.3NP_003787.2  unconventional prefoldin RPB5 interactor 1 isoform a

    See identical proteins and their annotated locations for NP_003787.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA678820, AK292170, AW003989, AW954529, BG742069, DB461036
    Consensus CDS
    CCDS12420.1
    UniProtKB/Swiss-Prot
    A8K805, H7BY42, O94763, Q8TC23, Q9UNU3
    UniProtKB/TrEMBL
    Q6NX55
    Related
    ENSP00000376097.2, ENST00000392271.6
    Conserved Domains (1) summary
    cl09111
    Location:38147
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RNA

  1. NR_045557.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA678820, AW003989, AW954529, BC067259, BG742069, DB461036

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    29923657..30016612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259362.3XP_005259419.1  unconventional prefoldin RPB5 interactor 1 isoform X1

    UniProtKB/TrEMBL
    Q6NX55
    Conserved Domains (1) summary
    cl09111
    Location:27129
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  2. XM_047439595.1XP_047295551.1  unconventional prefoldin RPB5 interactor 1 isoform X4

  3. XM_011527435.3XP_011525737.1  unconventional prefoldin RPB5 interactor 1 isoform X3

    UniProtKB/TrEMBL
    Q6NX55
    Conserved Domains (1) summary
    cl09111
    Location:899
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  4. XM_005259363.5XP_005259420.1  unconventional prefoldin RPB5 interactor 1 isoform X2

    UniProtKB/TrEMBL
    Q6NX55
    Conserved Domains (1) summary
    cl09111
    Location:38147
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  5. XM_047439596.1XP_047295552.1  unconventional prefoldin RPB5 interactor 1 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    32444098..32537026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322482.1XP_054178457.1  unconventional prefoldin RPB5 interactor 1 isoform X1

  2. XM_054322485.1XP_054178460.1  unconventional prefoldin RPB5 interactor 1 isoform X4

  3. XM_054322484.1XP_054178459.1  unconventional prefoldin RPB5 interactor 1 isoform X3

  4. XM_054322483.1XP_054178458.1  unconventional prefoldin RPB5 interactor 1 isoform X2

  5. XM_054322486.1XP_054178461.1  unconventional prefoldin RPB5 interactor 1 isoform X5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_134447.1: Suppressed sequence

    Description
    NM_134447.1: This RefSeq was permanently suppressed because it has an inhibitory upstream ORF and there is no support for the protein.