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URI1 URI1 prefoldin like chaperone [ Homo sapiens (human) ]

Gene ID: 8725, updated on 7-Jun-2020

Summary

Official Symbol
URI1provided by HGNC
Official Full Name
URI1 prefoldin like chaperoneprovided by HGNC
Primary source
HGNC:HGNC:13236
See related
Ensembl:ENSG00000105176 MIM:603494
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RMP; URI; NNX3; C19orf2; PPP1R19
Summary
This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in thyroid (RPKM 23.9), testis (RPKM 18.7) and 25 other tissues See more
Orthologs

Genomic context

See URI1 in Genome Data Viewer
Location:
19q12
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (29923650..30016612)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (30414551..30507519)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cyclin E1 Neighboring gene peptidylprolyl isomerase A pseudogene 58 Neighboring gene ribosomal protein L9 pseudogene 32 Neighboring gene VISTA enhancer hs381 Neighboring gene TATA-box binding protein associated factor 9 pseudogene 3 Neighboring gene VISTA enhancer hs382

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10575

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II complex binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
unconventional prefoldin RPB5 interactor 1
Names
RNA polymerase II subunit 5-mediating protein
RPB5-mediating protein
protein phosphatase 1, regulatory subunit 19

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047095.1 RefSeqGene

    Range
    5014..97969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001252641.2NP_001239570.1  unconventional prefoldin RPB5 interactor 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) is shorter and has distinct N- and C-termini, compared to isoform a.
    Source sequence(s)
    AA678820, AW003989, AW954529, BC026184, BG742069
    Consensus CDS
    CCDS58658.1
    UniProtKB/Swiss-Prot
    O94763
    Related
    ENSP00000353817.4, ENST00000360605.8
    Conserved Domains (1) summary
    cl09111
    Location:27129
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  2. NM_003796.3NP_003787.2  unconventional prefoldin RPB5 interactor 1 isoform a

    See identical proteins and their annotated locations for NP_003787.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA678820, AK292170, AW003989, AW954529, BG742069, DB461036
    Consensus CDS
    CCDS12420.1
    UniProtKB/Swiss-Prot
    O94763
    Related
    ENSP00000376097.2, ENST00000392271.6
    Conserved Domains (1) summary
    cl09111
    Location:38147
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RNA

  1. NR_045557.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA678820, AW003989, AW954529, BC067259, BG742069, DB461036

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    29923650..30016612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259362.2XP_005259419.1  unconventional prefoldin RPB5 interactor 1 isoform X1

    Conserved Domains (1) summary
    cl09111
    Location:27129
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  2. XM_011527435.2XP_011525737.1  unconventional prefoldin RPB5 interactor 1 isoform X3

    Conserved Domains (1) summary
    cl09111
    Location:899
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  3. XM_005259363.4XP_005259420.1  unconventional prefoldin RPB5 interactor 1 isoform X2

    Conserved Domains (1) summary
    cl09111
    Location:38147
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
  4. XM_024451751.1XP_024307519.1  unconventional prefoldin RPB5 interactor 1 isoform X4

    Conserved Domains (1) summary
    cl09111
    Location:171
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_134447.1: Suppressed sequence

    Description
    NM_134447.1: This RefSeq was permanently suppressed because it has an inhibitory upstream ORF and there is no support for the protein.
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