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JRKL JRK like [ Homo sapiens (human) ]

Gene ID: 8690, updated on 11-Jun-2021

Summary

Official Symbol
JRKLprovided by HGNC
Official Full Name
JRK likeprovided by HGNC
Primary source
HGNC:HGNC:6200
See related
Ensembl:ENSG00000183340 MIM:603211
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HHMJG
Summary
The function of this gene has not yet been defined, however, the encoded protein shares similarity with the human (41% identical) and mouse (34% identical) jerky gene products. This protein may act as a nuclear regulatory protein. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
Expression
Ubiquitous expression in ovary (RPKM 7.1), thyroid (RPKM 6.1) and 25 other tissues See more
Orthologs
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Genomic context

See JRKL in Genome Data Viewer
Location:
11q21
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (96390013..96393561)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (96123177..96126725)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene mastermind like transcriptional coactivator 2 Neighboring gene microRNA 1260b Neighboring gene coiled-coil domain containing 82 Neighboring gene JRKL antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 346 Neighboring gene long intergenic non-protein coding RNA 2737

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129608

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in central nervous system development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
jerky protein homolog-like
Names
human homolog of mouse jerky gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261833.2NP_001248762.1  jerky protein homolog-like

    See identical proteins and their annotated locations for NP_001248762.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF004715, AK290579, BC109202, CA503357
    Consensus CDS
    CCDS8308.1
    UniProtKB/Swiss-Prot
    Q9Y4A0
    Related
    ENSP00000333350.4, ENST00000332349.5
    Conserved Domains (3) summary
    smart00674
    Location:73139
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    pfam03184
    Location:206385
    DDE_1; DDE superfamily endonuclease
    cl21459
    Location:452
    HTH; Helix-turn-helix domains
  2. NM_003772.4NP_003763.2  jerky protein homolog-like

    See identical proteins and their annotated locations for NP_003763.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is intronless. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF004715, CA503357, DB030091, DB084056
    Consensus CDS
    CCDS8308.1
    UniProtKB/Swiss-Prot
    Q9Y4A0
    Conserved Domains (3) summary
    smart00674
    Location:73139
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    pfam03184
    Location:206385
    DDE_1; DDE superfamily endonuclease
    cl21459
    Location:452
    HTH; Helix-turn-helix domains

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    96390013..96393561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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