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VAMP4 vesicle associated membrane protein 4 [ Homo sapiens (human) ]

Gene ID: 8674, updated on 7-Dec-2018

Summary

Official Symbol
VAMP4provided by HGNC
Official Full Name
vesicle associated membrane protein 4provided by HGNC
Primary source
HGNC:HGNC:12645
See related
Ensembl:ENSG00000117533 MIM:606909
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VAMP-4; VAMP24
Summary
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 9.9), testis (RPKM 7.1) and 25 other tissues See more
Orthologs

Genomic context

See VAMP4 in Genome Data Viewer
Location:
1q24.3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (171700156..171742844, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (171669296..171711379, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene profilin 1 pseudogene 1 Neighboring gene ribosomal protein L4 pseudogene 3 Neighboring gene solute carrier family 5 member 4 pseudogene Neighboring gene solute carrier family 5 member 4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
NOT ER to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Golgi ribbon formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT Golgi to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
SNARE complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
membrane organization TAS
Traceable Author Statement
more info
 
microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle to endosome fusion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
clathrin-coated vesicle membrane TAS
Traceable Author Statement
more info
 
endosome TAS
Traceable Author Statement
more info
PubMed 
integral component of synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
lysosome TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
trans-Golgi network membrane TAS
Traceable Author Statement
more info
 
transport vesicle TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
vesicle-associated membrane protein 4
Names
VAMP4/TAF3 fusion

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185127.1NP_001172056.1  vesicle-associated membrane protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001172056.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    BC007019, DB167275, Z98751
    Consensus CDS
    CCDS53430.1
    UniProtKB/Swiss-Prot
    O75379
    Related
    ENSP00000356714.2, ENST00000367740.2
    Conserved Domains (1) summary
    cd15869
    Location:49115
    R-SNARE_VAMP4; SNARE motif of VAMP4
  2. NM_003762.5NP_003753.2  vesicle-associated membrane protein 4 isoform 1

    See identical proteins and their annotated locations for NP_003753.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL035296, DB167275, Z98751
    Consensus CDS
    CCDS1298.1
    UniProtKB/Swiss-Prot
    O75379
    UniProtKB/TrEMBL
    Q6IAZ3
    Related
    ENSP00000236192.7, ENST00000236192.11
    Conserved Domains (1) summary
    cd15869
    Location:50116
    R-SNARE_VAMP4; SNARE motif of VAMP4

RNA

  1. NR_033704.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. This transcript is a candidate for nonsense-mediated mRNA decay is not thought to be translated.
    Source sequence(s)
    AK290441, DB167275, Z98751

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    171700156..171742844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002713.2XP_016858202.1  vesicle-associated membrane protein 4 isoform X1

    Conserved Domains (1) summary
    cl22856
    Location:5073
    SNARE; SNARE motif

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_201994.1: Suppressed sequence

    Description
    NM_201994.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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