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EIF4G3 eukaryotic translation initiation factor 4 gamma 3 [ Homo sapiens (human) ]

Gene ID: 8672, updated on 6-Jan-2019

Summary

Official Symbol
EIF4G3provided by HGNC
Official Full Name
eukaryotic translation initiation factor 4 gamma 3provided by HGNC
Primary source
HGNC:HGNC:3298
See related
Ensembl:ENSG00000075151 MIM:603929
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
eIF4G 3; eIF4GII; eIF-4G 3
Summary
The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]
Expression
Broad expression in testis (RPKM 35.2), thyroid (RPKM 16.6) and 23 other tissues See more
Orthologs

Genomic context

See EIF4G3 in Genome Data Viewer
Location:
1p36.12
Exon count:
42
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (20806292..21176888, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (21132785..21503381, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268222 Neighboring gene SH2 domain containing 5 Neighboring gene heterochromatin protein 1 binding protein 3 Neighboring gene RNA, U7 small nuclear 200 pseudogene Neighboring gene uncharacterized LOC105376830 Neighboring gene uncharacterized LOC105376829 Neighboring gene NFE2L2 motif-containing MPRA enhancer 38 Neighboring gene microRNA 1256 Neighboring gene ribosomal protein S15a pseudogene 6 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 27 Neighboring gene endothelin converting enzyme 1 Neighboring gene uncharacterized LOC100506801 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 11 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from BioSystems

  • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
    Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemThe ISG proteins generated by IFN pathways plays key roles in the induction of innate and adaptive immune responses.
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
    ISG15 antiviral mechanism, organism-specific biosystemInterferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (Ubl) family. It is strongly induced upon exposure to type I Interferons (IFNs), viruses, bacterial LPS, and other stresses. On...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • Translation Factors, organism-specific biosystem (from WikiPathways)
    Translation Factors, organism-specific biosystemProtein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, ...
  • Viral myocarditis, organism-specific biosystem (from KEGG)
    Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
  • eIF4F complex, organism-specific biosystem (from KEGG)
    eIF4F complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
  • eIF4F complex, conserved biosystem (from KEGG)
    eIF4F complex, conserved biosystemStructural complex; Genetic information processing; RNA processing

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA cap binding IEA
Inferred from Electronic Annotation
more info
 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation factor activity, RNA binding TAS
Traceable Author Statement
more info
PubMed 
translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
NOT negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of translational initiation TAS
Traceable Author Statement
more info
PubMed 
translational initiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 4 gamma 3
Names
eIF-4-gamma 3
eIF-4-gamma II

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047026.1 RefSeqGene

    Range
    5433..376029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001198801.1NP_001185730.1  eukaryotic translation initiation factor 4 gamma 3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB209119, BC072413, BC094683, BF084093, CN402454
    Consensus CDS
    CCDS72723.1
    UniProtKB/Swiss-Prot
    O43432
    UniProtKB/TrEMBL
    A0A0A0MSA7, Q59GJ0
    Related
    ENSP00000383274.2, ENST00000400422.6
    Conserved Domains (4) summary
    cd11559
    Location:14641592
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:12581370
    MA3; MA3 domain
    pfam02854
    Location:7911019
    MIF4G; MIF4G domain
    cl17013
    Location:15711617
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  2. NM_001198802.1NP_001185731.1  eukaryotic translation initiation factor 4 gamma 3 isoform 2

    See identical proteins and their annotated locations for NP_001185731.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional in-frame smaller exon in the 5' coding region and lacks an in-frame larger exon in the middle coding region, as compared to variant 1. The resulting isoform (2) has an extra smaller segment in one region and lacks a larger segment in another region, as compared to isoform 1.
    Source sequence(s)
    AB209119, BC072413, BC094683, BF084093, CN402454
    Consensus CDS
    CCDS55580.1
    UniProtKB/Swiss-Prot
    O43432
    UniProtKB/TrEMBL
    Q59GJ0
    Related
    ENSP00000473510.1, ENST00000602326.5
    Conserved Domains (4) summary
    cd11559
    Location:14341562
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:12281340
    MA3; MA3 domain
    pfam02854
    Location:761989
    MIF4G; MIF4G domain
    cl17013
    Location:15411587
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  3. NM_001198803.2NP_001185732.1  eukaryotic translation initiation factor 4 gamma 3 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' UTR and an additional in-frame exon in the 5' coding region, and lacks multiple 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (4) has an extra internal segment and a distinct and much shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AL358392, AL627311, BC030578
    Consensus CDS
    CCDS59192.1
    UniProtKB/Swiss-Prot
    O43432
    Related
    ENSP00000349386.3, ENST00000356916.7
    Conserved Domains (1) summary
    cl25764
    Location:188
    PAT1; Topoisomerase II-associated protein PAT1
  4. NM_003760.4NP_003751.2  eukaryotic translation initiation factor 4 gamma 3 isoform 3

    See identical proteins and their annotated locations for NP_003751.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AB209119, AF012072, BC094683, BF084093
    Consensus CDS
    CCDS214.1
    UniProtKB/Swiss-Prot
    O43432
    UniProtKB/TrEMBL
    Q59GJ0
    Related
    ENSP00000264211.7, ENST00000264211.12
    Conserved Domains (5) summary
    cd11559
    Location:14281556
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:12221334
    MA3; MA3 domain
    pfam02854
    Location:755983
    MIF4G; MIF4G domain
    pfam17040
    Location:138333
    CBP_CCPA; Cellulose-complementing protein A
    cl17013
    Location:15351581
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    20806292..21176888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542374.2XP_011540676.1  eukaryotic translation initiation factor 4 gamma 3 isoform X19

    See identical proteins and their annotated locations for XP_011540676.1

    Conserved Domains (5) summary
    cd11559
    Location:14651593
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:12591371
    MA3; MA3 domain
    pfam02854
    Location:7921020
    MIF4G; MIF4G domain
    pfam17040
    Location:138333
    CBP_CCPA; Cellulose-complementing protein A
    cl17013
    Location:15721618
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  2. XM_017002693.2XP_016858182.1  eukaryotic translation initiation factor 4 gamma 3 isoform X19

    Conserved Domains (5) summary
    cd11559
    Location:14651593
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:12591371
    MA3; MA3 domain
    pfam02854
    Location:7921020
    MIF4G; MIF4G domain
    pfam17040
    Location:138333
    CBP_CCPA; Cellulose-complementing protein A
    cl17013
    Location:15721618
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  3. XM_017002702.2XP_016858191.1  eukaryotic translation initiation factor 4 gamma 3 isoform X28

    Conserved Domains (5) summary
    cd11559
    Location:14051533
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:11991311
    MA3; MA3 domain
    pfam02854
    Location:732960
    MIF4G; MIF4G domain
    pfam11235
    Location:104232
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    cl17013
    Location:15121558
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  4. XM_017002701.2XP_016858190.1  eukaryotic translation initiation factor 4 gamma 3 isoform X27

    Related
    ENSP00000489051.1, ENST00000634879.1
    Conserved Domains (4) summary
    cd11559
    Location:14271555
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:12211333
    MA3; MA3 domain
    pfam02854
    Location:754982
    MIF4G; MIF4G domain
    cl17013
    Location:15341580
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  5. XM_017002708.2XP_016858197.1  eukaryotic translation initiation factor 4 gamma 3 isoform X34

    UniProtKB/Swiss-Prot
    O43432
    Related
    ENSP00000364071.3, ENST00000374935.7
    Conserved Domains (4) summary
    cd11559
    Location:11481276
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:9421054
    MA3; MA3 domain
    pfam02854
    Location:475703
    MIF4G; MIF4G domain
    cl17013
    Location:12551301
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  6. XM_017002707.2XP_016858196.1  eukaryotic translation initiation factor 4 gamma 3 isoform X33

    Conserved Domains (4) summary
    cd11559
    Location:11851313
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:9791091
    MA3; MA3 domain
    pfam02854
    Location:512740
    MIF4G; MIF4G domain
    cl17013
    Location:12921338
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  7. XM_017002692.2XP_016858181.1  eukaryotic translation initiation factor 4 gamma 3 isoform X19

    Conserved Domains (5) summary
    cd11559
    Location:14651593
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:12591371
    MA3; MA3 domain
    pfam02854
    Location:7921020
    MIF4G; MIF4G domain
    pfam17040
    Location:138333
    CBP_CCPA; Cellulose-complementing protein A
    cl17013
    Location:15721618
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  8. XM_017002690.2XP_016858179.1  eukaryotic translation initiation factor 4 gamma 3 isoform X17

  9. XM_017002698.2XP_016858187.1  eukaryotic translation initiation factor 4 gamma 3 isoform X24

  10. XM_017002687.2XP_016858176.1  eukaryotic translation initiation factor 4 gamma 3 isoform X15

    Conserved Domains (5) summary
    cd11559
    Location:14721600
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:12661378
    MA3; MA3 domain
    pfam02854
    Location:7991027
    MIF4G; MIF4G domain
    pfam11235
    Location:171299
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    cl17013
    Location:15791625
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  11. XM_017002697.2XP_016858186.1  eukaryotic translation initiation factor 4 gamma 3 isoform X23

  12. XM_017002696.2XP_016858185.1  eukaryotic translation initiation factor 4 gamma 3 isoform X22

  13. XM_017002683.2XP_016858172.1  eukaryotic translation initiation factor 4 gamma 3 isoform X12

    Conserved Domains (4) summary
    cd11559
    Location:14761604
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:12701382
    MA3; MA3 domain
    pfam02854
    Location:8031031
    MIF4G; MIF4G domain
    cl17013
    Location:15831629
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  14. XM_017002695.2XP_016858184.1  eukaryotic translation initiation factor 4 gamma 3 isoform X21

  15. XM_017002681.2XP_016858170.1  eukaryotic translation initiation factor 4 gamma 3 isoform X10

  16. XM_017002694.2XP_016858183.1  eukaryotic translation initiation factor 4 gamma 3 isoform X20

  17. XM_017002679.2XP_016858168.1  eukaryotic translation initiation factor 4 gamma 3 isoform X9

    Conserved Domains (4) summary
    cd11559
    Location:14831611
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:12771389
    MA3; MA3 domain
    pfam02854
    Location:8101038
    MIF4G; MIF4G domain
    cl17013
    Location:15901636
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  18. XM_017002691.2XP_016858180.1  eukaryotic translation initiation factor 4 gamma 3 isoform X18

  19. XM_017002676.2XP_016858165.1  eukaryotic translation initiation factor 4 gamma 3 isoform X6

    Conserved Domains (5) summary
    cd11559
    Location:15031631
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:12971409
    MA3; MA3 domain
    pfam02854
    Location:8301058
    MIF4G; MIF4G domain
    pfam11235
    Location:202330
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    cl17013
    Location:16101656
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  20. XM_017002686.2XP_016858175.1  eukaryotic translation initiation factor 4 gamma 3 isoform X14

  21. XM_017002685.2XP_016858174.1  eukaryotic translation initiation factor 4 gamma 3 isoform X13

  22. XM_017002675.2XP_016858164.1  eukaryotic translation initiation factor 4 gamma 3 isoform X5

    Conserved Domains (5) summary
    cd11559
    Location:15101638
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:13041416
    MA3; MA3 domain
    pfam02854
    Location:8371065
    MIF4G; MIF4G domain
    pfam11235
    Location:209337
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    cl17013
    Location:16171663
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  23. XM_017002682.2XP_016858171.1  eukaryotic translation initiation factor 4 gamma 3 isoform X11

  24. XM_017002674.2XP_016858163.1  eukaryotic translation initiation factor 4 gamma 3 isoform X4

  25. XM_017002673.2XP_016858162.1  eukaryotic translation initiation factor 4 gamma 3 isoform X3

    Conserved Domains (5) summary
    cd11559
    Location:15141642
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:13081420
    MA3; MA3 domain
    pfam02854
    Location:8411069
    MIF4G; MIF4G domain
    pfam11235
    Location:213341
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    cl17013
    Location:16211667
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  26. XM_011542361.3XP_011540663.1  eukaryotic translation initiation factor 4 gamma 3 isoform X8

    Conserved Domains (4) summary
    cd11559
    Location:14831611
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:12771389
    MA3; MA3 domain
    pfam02854
    Location:8101038
    MIF4G; MIF4G domain
    cl17013
    Location:15901636
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  27. XM_011542356.3XP_011540658.1  eukaryotic translation initiation factor 4 gamma 3 isoform X2

    Conserved Domains (4) summary
    cd11559
    Location:15201648
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:13141426
    MA3; MA3 domain
    pfam02854
    Location:8471075
    MIF4G; MIF4G domain
    cl17013
    Location:16271673
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  28. XM_017002706.2XP_016858195.1  eukaryotic translation initiation factor 4 gamma 3 isoform X32

    Conserved Domains (4) summary
    cd11559
    Location:12041332
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:9981110
    MA3; MA3 domain
    pfam02854
    Location:531759
    MIF4G; MIF4G domain
    cl17013
    Location:13111357
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  29. XM_017002705.2XP_016858194.1  eukaryotic translation initiation factor 4 gamma 3 isoform X31

    Conserved Domains (4) summary
    cd11559
    Location:12411369
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:10351147
    MA3; MA3 domain
    pfam02854
    Location:568796
    MIF4G; MIF4G domain
    cl17013
    Location:13481394
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  30. XM_017002678.2XP_016858167.1  eukaryotic translation initiation factor 4 gamma 3 isoform X7

    Conserved Domains (4) summary
    cd11559
    Location:14841612
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:12781390
    MA3; MA3 domain
    pfam02854
    Location:8111039
    MIF4G; MIF4G domain
    cl17013
    Location:15911637
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  31. XM_011542370.2XP_011540672.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

    See identical proteins and their annotated locations for XP_011540672.1

    Conserved Domains (4) summary
    cd11559
    Location:15211649
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:13151427
    MA3; MA3 domain
    pfam02854
    Location:8481076
    MIF4G; MIF4G domain
    cl17013
    Location:16281674
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  32. XM_017002704.2XP_016858193.1  eukaryotic translation initiation factor 4 gamma 3 isoform X30

  33. XM_011542375.3XP_011540677.1  eukaryotic translation initiation factor 4 gamma 3 isoform X19

    See identical proteins and their annotated locations for XP_011540677.1

    Conserved Domains (5) summary
    cd11559
    Location:14651593
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:12591371
    MA3; MA3 domain
    pfam02854
    Location:7921020
    MIF4G; MIF4G domain
    pfam17040
    Location:138333
    CBP_CCPA; Cellulose-complementing protein A
    cl17013
    Location:15721618
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  34. XM_017002684.2XP_016858173.1  eukaryotic translation initiation factor 4 gamma 3 isoform X12

    Conserved Domains (4) summary
    cd11559
    Location:14761604
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:12701382
    MA3; MA3 domain
    pfam02854
    Location:8031031
    MIF4G; MIF4G domain
    cl17013
    Location:15831629
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  35. XM_017002672.2XP_016858161.1  eukaryotic translation initiation factor 4 gamma 3 isoform X1

    Conserved Domains (4) summary
    cd11559
    Location:15211649
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:13151427
    MA3; MA3 domain
    pfam02854
    Location:8481076
    MIF4G; MIF4G domain
    cl17013
    Location:16281674
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  36. XM_017002703.2XP_016858192.1  eukaryotic translation initiation factor 4 gamma 3 isoform X29

  37. XM_011542381.3XP_011540683.1  eukaryotic translation initiation factor 4 gamma 3 isoform X36

    Conserved Domains (4) summary
    cd11559
    Location:9801108
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:774886
    MA3; MA3 domain
    pfam02854
    Location:307535
    MIF4G; MIF4G domain
    cl17013
    Location:10871133
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  38. XM_017002700.2XP_016858189.1  eukaryotic translation initiation factor 4 gamma 3 isoform X26

    UniProtKB/Swiss-Prot
    O43432
    Conserved Domains (5) summary
    cd11559
    Location:14281556
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:12221334
    MA3; MA3 domain
    pfam02854
    Location:755983
    MIF4G; MIF4G domain
    pfam17040
    Location:138333
    CBP_CCPA; Cellulose-complementing protein A
    cl17013
    Location:15351581
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  39. XM_017002709.2XP_016858198.1  eukaryotic translation initiation factor 4 gamma 3 isoform X35

  40. XM_017002699.2XP_016858188.1  eukaryotic translation initiation factor 4 gamma 3 isoform X25

  41. XM_017002689.2XP_016858178.1  eukaryotic translation initiation factor 4 gamma 3 isoform X16

    Conserved Domains (4) summary
    cd11559
    Location:15211600
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:13151427
    MA3; MA3 domain
    pfam02854
    Location:8481076
    MIF4G; MIF4G domain
    cl17013
    Location:15781627
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  42. XM_011542371.2XP_011540673.1  eukaryotic translation initiation factor 4 gamma 3 isoform X12

    See identical proteins and their annotated locations for XP_011540673.1

    Conserved Domains (4) summary
    cd11559
    Location:14761604
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:12701382
    MA3; MA3 domain
    pfam02854
    Location:8031031
    MIF4G; MIF4G domain
    cl17013
    Location:15831629
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  43. XM_017002677.2XP_016858166.1  eukaryotic translation initiation factor 4 gamma 3 isoform X6

    Conserved Domains (5) summary
    cd11559
    Location:15031631
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02847
    Location:12971409
    MA3; MA3 domain
    pfam02854
    Location:8301058
    MIF4G; MIF4G domain
    pfam11235
    Location:202330
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    cl17013
    Location:16101656
    W2; C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
  44. XM_017002711.2XP_016858200.1  eukaryotic translation initiation factor 4 gamma 3 isoform X38

  45. XM_017002710.2XP_016858199.1  eukaryotic translation initiation factor 4 gamma 3 isoform X37

  46. XM_024450533.1XP_024306301.1  eukaryotic translation initiation factor 4 gamma 3 isoform X39

    Conserved Domains (2) summary
    cl25764
    Location:52133
    PAT1; Topoisomerase II-associated protein PAT1
    cl26464
    Location:52383
    Atrophin-1; Atrophin-1 family

RNA

  1. XR_002957948.1 RNA Sequence

  2. XR_002957947.1 RNA Sequence

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