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SSNA1 SS nuclear autoantigen 1 [ Homo sapiens (human) ]

Gene ID: 8636, updated on 13-Aug-2022

Summary

Official Symbol
SSNA1provided by HGNC
Official Full Name
SS nuclear autoantigen 1provided by HGNC
Primary source
HGNC:HGNC:11321
See related
Ensembl:ENSG00000176101 MIM:610882; AllianceGenome:HGNC:11321
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
N14; NA14; NA-14
Summary
Enables identical protein binding activity. Predicted to act upstream of or within ciliary receptor clustering involved in smoothened signaling pathway and intraciliary transport. Located in centrosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 42.7), kidney (RPKM 20.7) and 25 other tissues See more
Orthologs
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Genomic context

See SSNA1 in Genome Data Viewer
Location:
9q34.3
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (137188676..137190366)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (149426339..149428029)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (140083128..140084818)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902315 Neighboring gene transmembrane protein 210 Neighboring gene anaphase promoting complex subunit 2 Neighboring gene taperin Neighboring gene transmembrane protein 203

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein self-association IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in axon arborization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon extension ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ciliary receptor clustering involved in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in intraciliary transport IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microtubule cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in microtubule nucleation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in axoneme IDA
Inferred from Direct Assay
more info
PubMed 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in supramolecular fiber IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
microtubule nucleation factor SSNA1
Names
Sjogren syndrome nuclear autoantigen 1
Sjogren's syndrome nuclear autoantigen 1
nuclear autoantigen of 14 kDa
sjoegren syndrome nuclear autoantigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003731.3NP_003722.2  microtubule nucleation factor SSNA1

    See identical proteins and their annotated locations for NP_003722.2

    Status: VALIDATED

    Source sequence(s)
    BC000864
    Consensus CDS
    CCDS7034.1
    UniProtKB/Swiss-Prot
    O43805, Q9BVW8
    UniProtKB/TrEMBL
    A0A024R8G6
    Related
    ENSP00000313752.5, ENST00000322310.10
    Conserved Domains (1) summary
    pfam04111
    Location:1398
    APG6; Autophagy protein Apg6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    137188676..137190366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    149426339..149428029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)