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RGS20 regulator of G protein signaling 20 [ Homo sapiens (human) ]

Gene ID: 8601, updated on 24-Nov-2020

Summary

Official Symbol
RGS20provided by HGNC
Official Full Name
regulator of G protein signaling 20provided by HGNC
Primary source
HGNC:HGNC:14600
See related
Ensembl:ENSG00000147509 MIM:607193
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RGSZ1; ZGAP1; gz-GAP; g(z)GAP
Summary
The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Expression
Biased expression in brain (RPKM 2.5), thyroid (RPKM 0.6) and 3 other tissues See more
Orthologs

Genomic context

See RGS20 in Genome Data Viewer
Location:
8q11.23
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (53851795..53959304)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (54764368..54871863)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene chromosome 5 open reading frame 13 pseudogene Neighboring gene ATPase H+ transporting V1 subunit H Neighboring gene Sharpr-MPRA regulatory region 5984 Neighboring gene RPS27A pseudogene 13 Neighboring gene RNA, U6 small nuclear 1331, pseudogene Neighboring gene Sharpr-MPRA regulatory region 792/14152 Neighboring gene ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) pseudogene Neighboring gene transcription elongation factor A1 Neighboring gene uncharacterized LOC105375839

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity TAS
Traceable Author Statement
more info
PubMed 
GTPase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
trans-Golgi network IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
regulator of G-protein signaling 20
Names
gz-selective GTPase-activating protein
regulator of G-protein signaling 20 variant 2
regulator of G-protein signaling Z1
regulator of G-protein signalling 20
regulator of Gz-selective protein signaling 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286673.2NP_001273602.1  regulator of G-protein signaling 20 isoform c

    See identical proteins and their annotated locations for NP_001273602.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region comapred to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC100821, AC113194, AF366054
    Consensus CDS
    CCDS69482.1
    UniProtKB/Swiss-Prot
    O76081
    Related
    ENSP00000344630.6, ENST00000344277.10
    Conserved Domains (1) summary
    cd08746
    Location:106261
    RGS_RGS20; Regulator of G protein signaling (RGS) domain found in the RGS20 protein
  2. NM_001286674.2NP_001273603.1  regulator of G-protein signaling 20 isoform d

    See identical proteins and their annotated locations for NP_001273603.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three in-frame exons in the central coding region which results in the use of an alternate start codon compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC100821, AC113194, AF366056
    UniProtKB/Swiss-Prot
    O76081
    Conserved Domains (1) summary
    cl02565
    Location:12140
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  3. NM_001286675.2NP_001273604.1  regulator of G-protein signaling 20 isoform e

    See identical proteins and their annotated locations for NP_001273604.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two in-frame exons in the central coding region which results in the use of an alternate start codon compared to variant 1. The encoded isoform (e) is shorter than isoform a.
    Source sequence(s)
    AC100821, AC113194, AF366055
    UniProtKB/Swiss-Prot
    O76081
    Conserved Domains (1) summary
    cl02565
    Location:11168
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  4. NM_003702.4NP_003693.2  regulator of G-protein signaling 20 isoform b

    See identical proteins and their annotated locations for NP_003693.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC100821, AK094503, BC063490
    Consensus CDS
    CCDS6156.1
    UniProtKB/Swiss-Prot
    O76081
    UniProtKB/TrEMBL
    B3KSW4, H9NIM5
    Related
    ENSP00000276500.4, ENST00000276500.4
    Conserved Domains (1) summary
    cd08746
    Location:74229
    RGS_RGS20; Regulator of G protein signaling (RGS) domain found in the RGS20 protein
  5. NM_170587.4NP_733466.1  regulator of G-protein signaling 20 isoform a

    See identical proteins and their annotated locations for NP_733466.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC100821, AC113194, AY046538
    Consensus CDS
    CCDS6155.1
    UniProtKB/Swiss-Prot
    O76081
    Related
    ENSP00000297313.3, ENST00000297313.8
    Conserved Domains (1) summary
    cd08746
    Location:221376
    RGS_RGS20; Regulator of G protein signaling (RGS) domain found in the RGS20 protein

RNA

  1. NR_104578.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate exon structure compared to variant 1 but does share exon structure with variant 2. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
    Source sequence(s)
    BC054867
    Related
    ENST00000523064.1
  2. NR_104579.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC100821, AC113194, AK094503
    Related
    ENST00000522225.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    53851795..53959304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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