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TMEFF1 transmembrane protein with EGF like and two follistatin like domains 1 [ Homo sapiens (human) ]

Gene ID: 8577, updated on 13-Mar-2020

Summary

Official Symbol
TMEFF1provided by HGNC
Official Full Name
transmembrane protein with EGF like and two follistatin like domains 1provided by HGNC
Primary source
HGNC:HGNC:11866
See related
Ensembl:ENSG00000241697 MIM:603421
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TR-1; H7365; C9orf2; CT120.1
Expression
Biased expression in brain (RPKM 20.3), testis (RPKM 3.9) and 6 other tissues See more
Orthologs

Genomic context

See TMEFF1 in Genome Data Viewer
Location:
9q31.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (100473149..100577636)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (103235520..103339918)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376177 Neighboring gene MSANTD3-TMEFF1 readthrough Neighboring gene Myb/SANT DNA binding domain containing 3 Neighboring gene Sharpr-MPRA regulatory region 4026 Neighboring gene RN7SK pseudogene 87 Neighboring gene caveolae associated protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough MSANTD3-TMEFF1

Readthrough gene: MSANTD3-TMEFF1, Included gene: MSANTD3

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
motor neuron axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuromuscular junction development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tissue development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tomoregulin-1
Names
cancer/testis antigen family 120, member 1
transmembrane protein with EGF-like and one follistatin-like domain

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003692.5NP_003683.2  tomoregulin-1 precursor

    See identical proteins and their annotated locations for NP_003683.2

    Status: VALIDATED

    Source sequence(s)
    AL353805, BC021991, BC035056, BF436262, DN602026
    Consensus CDS
    CCDS6750.1
    UniProtKB/Swiss-Prot
    Q8IYR6
    Related
    ENSP00000364013.4, ENST00000374879.5
    Conserved Domains (2) summary
    smart00280
    Location:99143
    KAZAL; Kazal type serine protease inhibitors
    cl28647
    Location:275311
    PHA02887; EGF-like protein; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    100473149..100577636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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