U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RNR1 ribonucleotide-diphosphate reductase subunit RNR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856801, updated on 4-Feb-2024

Summary

Gene symbol
RNR1
Gene description
ribonucleotide-diphosphate reductase subunit RNR1
Primary source
SGD:S000000872
Locus tag
YER070W
See related
AllianceGenome:SGD:S000000872
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CRT7; RIR1; SDS12
Summary
Enables nucleotide binding activity and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in deoxyribonucleotide biosynthetic process. Located in cytoplasm. Part of ribonucleoside-diphosphate reductase complex. Orthologous to human RRM1 (ribonucleotide reductase catalytic subunit M1). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See RNR1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (298950..301616)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene CCR4-NOT core ubiquitin-protein ligase subunit MOT2 Neighboring gene bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase Neighboring gene Tda2p Neighboring gene Vtc1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in deoxyribonucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in deoxyribonucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in deoxyribonucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
part_of ribonucleoside-diphosphate reductase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ribonucleoside-diphosphate reductase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribonucleotide-diphosphate reductase subunit RNR1
NP_010993.1
  • Major isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; relative distribution to the nucleus increases upon DNA replication stress; RNR1 has a paralog, RNR3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    298950..301616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178961.1NP_010993.1  TPA: ribonucleotide-diphosphate reductase subunit RNR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010993.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLX5, P21524
    UniProtKB/TrEMBL
    A0A8H8ULT7, A6ZR24, B3LRI7, C7GRQ2, C8Z778, N1PA44
    Conserved Domains (1) summary
    PLN02437
    Location:1758
    PLN02437; ribonucleoside--diphosphate reductase large subunit