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SIT1 siderophore transporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 856644, updated on 18-Sep-2024

Summary

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Official Symbol
SIT1
Official Full Name
siderophore transporter
Primary source
SGD:S000000791
Locus tag
YEL065W
See related
AllianceGenome:SGD:S000000791; FungiDB:YEL065W; VEuPathDB:YEL065W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ARN3
Summary
Enables siderophore uptake transmembrane transporter activity. Involved in cellular iron ion homeostasis; siderophore transport; and transmembrane transport. Located in endosome. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SIT1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (27657..29543)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene D-amino-acid N-acetyltransferase Neighboring gene Avt2p Neighboring gene arginine permease CAN1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel function of Aft1 in regulating ferrioxamine B uptake: Aft1 modulates Arn3 ubiquitination in Saccharomyces cerevisiae. Jeong MY, et al. Biochem J, 2009 Jul 29. PMID 19469713
  2. Sed1p interacts with Arn3p physically and mediates ferrioxamine B uptake in Saccharomyces cerevisiae. Park YS, et al. Curr Genet, 2005 Mar. PMID 15611868
  3. Ferrichrome induces endosome to plasma membrane cycling of the ferrichrome transporter, Arn1p, in Saccharomyces cerevisiae. Kim Y, et al. EMBO J, 2002 Jul 15. PMID 12110576, Free PMC Article
  4. Physical interaction between Sit1 and Aft1 upregulates FOB uptake activity by inhibiting protein degradation of Sit1 in Saccharomyces cerevisiae. Kang CM, et al. FEMS Yeast Res, 2015 Nov. PMID 26323600
  5. FgEnd1 is a putative component of the endocytic machinery and mediates ferrichrome uptake in F. graminearum. Kim JH, et al. Curr Genet, 2009 Dec. PMID 19756628

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Taken together, these results suggest that the protein-protein interaction between Sit1 and Aft1 is an important factor in the ferrioxamine B uptake activity of Sit1.
    Title: Physical interaction between Sit1 and Aft1 upregulates FOB uptake activity by inhibiting protein degradation of Sit1 in Saccharomyces cerevisiae.
  2. These results suggest that Aft1 interacts with Arn3 and may regulate the ubiquitination of Arn3 in the cytosolic compartment.
    Title: A novel function of Aft1 in regulating ferrioxamine B uptake: Aft1 modulates Arn3 ubiquitination in Saccharomyces cerevisiae.
  3. analysis of substrate- and ubiquitin-dependent trafficking of the yeast siderophore transporter Sit1
    Title: Substrate- and ubiquitin-dependent trafficking of the yeast siderophore transporter Sit1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables siderophore uptake transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables siderophore-iron transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular iron ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular iron ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in siderophore transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in siderophore transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in siderophore-dependent iron import into cell IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
siderophore transporter
NP_010849.3
  • Ferrioxamine B transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    27657..29543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178880.3 → NP_010849.3  TPA: siderophore transporter [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010849.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLI5, E9P951, P39980
    UniProtKB/TrEMBL
    A6ZQN6, N1PA34
    Conserved Domains (1) summary
    cd17322
    Location:70 → 582
    MFS_ARN_like; Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39980.1

Gene LinkOut

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