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CHS7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856545, updated on 22-Aug-2024

Summary

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Official Symbol
CHS7
Primary source
FungiDB:YHR142W
Locus tag
YHR142W
See related
SGD:S000001184; AllianceGenome:SGD:S000001184; VEuPathDB:YHR142W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables unfolded protein binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; fungal-type cell wall chitin biosynthetic process; and protein folding. Located in cellular bud neck and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (383538..384488)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ribosomal 60S subunit protein L42B Neighboring gene Dse2p Neighboring gene DNA-directed RNA polymerase core subunit RPC10

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Candida albicans strains deficient in CHS7, a key regulator of chitin synthase III, exhibit morphogenetic alterations and attenuated virulence. Sanz M, et al. Microbiology (Reading), 2005 Aug. PMID 16079341
  2. The chaperone Chs7 forms a stable complex with Chs3 and promotes its activity at the cell surface. Dharwada ST, et al. Traffic, 2018 Apr. PMID 29405545
  3. Chs7p, a new protein involved in the control of protein export from the endoplasmic reticulum that is specifically engaged in the regulation of chitin synthesis in Saccharomyces cerevisiae. Trilla JA, et al. J Cell Biol, 1999 Jun 14. PMID 10366589, Free PMC Article
  4. Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER. Kota J, et al. J Cell Biol, 2005 Jan 3. PMID 15623581, Free PMC Article
  5. In Vitro and In Vivo Studies on the Structural Organization of Chs3 from Saccharomyces cerevisiae. Gohlke S, et al. Int J Mol Sci, 2017 Mar 25. PMID 28346351, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chitin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in prospore membrane HDA PubMed 

General protein information

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Preferred Names
Chs7p
NP_012011.1
  • hypothetical protein; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    383538..384488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179272.1 → NP_012011.1  TPA: Chs7p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012011.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL91, P38843
    UniProtKB/TrEMBL
    A6ZT50, B3LSQ6, C7GXW2, C8Z9T9, G2WFL5, N1P9G2
    Conserved Domains (1) summary
    pfam12271
    Location:2 → 299
    Chs3p; Chitin synthase III catalytic subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38843.1

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