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NAM8 Nam8p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856486, updated on 18-Sep-2024

Summary

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Official Symbol
NAM8
Official Full Name
Nam8p
Primary source
SGD:S000001128
Locus tag
YHR086W
See related
AllianceGenome:SGD:S000001128; FungiDB:YHR086W; VEuPathDB:YHR086W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MRE2; MUD15
Summary
Enables mRNA binding activity. Involved in mRNA splice site selection and positive regulation of mRNA splicing, via spliceosome. Located in cytoplasm and nucleus. Part of U1 snRNP; U2-type prespliceosome; and commitment complex. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein) and TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (278153..279724)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene homeodomain family transcription factor STE12 Neighboring gene Ipi1p Neighboring gene uncharacterized protein Neighboring gene Rtc3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interaction of the U1 snRNP with nonconserved intronic sequences affects 5' splice site selection. Puig O, et al. Genes Dev, 1999 Mar 1. PMID 10072385, Free PMC Article
  2. The NAM8 gene in Saccharomyces cerevisiae encodes a protein with putative RNA binding motifs and acts as a suppressor of mitochondrial splicing deficiencies when overexpressed. Ekwall K, et al. Mol Gen Genet, 1992 May. PMID 1603056
  3. A novel class of mRNA-containing cytoplasmic granules are produced in response to UV-irradiation. Gaillard H, et al. Mol Biol Cell, 2008 Nov. PMID 18768757, Free PMC Article
  4. Splicing of the meiosis-specific HOP2 transcript utilizes a unique 5' splice site. Leu JY, et al. Mol Cell Biol, 1999 Dec. PMID 10567519, Free PMC Article
  5. Involvement of the MRE2 gene of yeast in formation of meiosis-specific double-strand breaks and crossover recombination through RNA splicing. Nakagawa T, et al. Genes Cells, 1997 Jan. PMID 9112441

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splice site recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splice site recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in positive regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of U1 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2-type prespliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of commitment complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nam8p
NP_011954.1
  • RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    278153..279724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179216.1 → NP_011954.1  TPA: Nam8p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011954.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL37, Q00539
    UniProtKB/TrEMBL
    B3LSK3, B5VK18, C8Z9N0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00539.2

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