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ARR3 Arr3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856331, updated on 2-Nov-2024

Summary

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Official Symbol
ARR3
Official Full Name
Arr3p
Primary source
SGD:S000006405
Locus tag
YPR201W
See related
AllianceGenome:SGD:S000006405; FungiDB:YPR201W; VEuPathDB:YPR201W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ACR3
Summary
Enables antimonite transmembrane transporter activity; antiporter activity; and arsenite transmembrane transporter activity. Involved in antimonite transmembrane transport and arsenite transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ARR3 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (939922..941136)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Arr1p Neighboring gene Arr2p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Y' element ATP-dependent helicase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Heterologous expression of the yeast arsenite efflux system ACR3 improves Arabidopsis thaliana tolerance to arsenic stress. Ali W, et al. New Phytol, 2012 May. PMID 22380876
  2. Microevolution of Cryptococcus neoformans driven by massive tandem gene amplification. Chow EW, et al. Mol Biol Evol, 2012 Aug. PMID 22334577
  3. Multiple cysteine residues are necessary for sorting and transport activity of the arsenite permease Acr3p from Saccharomyces cerevisiae. Maciaszczyk-Dziubinska E, et al. Biochim Biophys Acta, 2014 Mar. PMID 24291645
  4. The Saccharomyces cerevisiae ACR3 gene encodes a putative membrane protein involved in arsenite transport. Wysocki R, et al. J Biol Chem, 1997 Nov 28. PMID 9374482
  5. Identification of critical residues for transport activity of Acr3p, the Saccharomyces cerevisiae As(III)/H+ antiporter. Markowska K, et al. Mol Microbiol, 2015 Oct. PMID 26123064

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endocytic degradation of Acr3 is promoted by the ubiquitin ligase Rsp5 and requires polyubiquitination of Acr3 at multiple lysine residues via lysine 63-linked ubiquitin chains.
    Title: Rsp5-dependent endocytosis and degradation of the arsenite transporter Acr3 requires its N-terminal acidic tail as an endocytic sorting signal and arrestin-related ubiquitin-ligase adaptors.
  2. Transmembrane topology of the arsenite permease Acr3 from Saccharomyces cerevisiae has been reported.
    Title: Transmembrane topology of the arsenite permease Acr3 from Saccharomyces cerevisiae.
  3. study identified several charged/polar and aromatic residues of Acr3p localized in the predicted transmembrane segments of the yeast arsenite transporter Acr3p that are important for As(III)/H+ antiport activity
    Title: Identification of critical residues for transport activity of Acr3p, the Saccharomyces cerevisiae As(III)/H+ antiporter.
  4. Heterologous expression of yeast ACR3 endows plants with greater arsenic resistance, but does not lower significantly arsenic tissue levels.
    Title: Heterologous expression of the yeast arsenite efflux system ACR3 improves Arabidopsis thaliana tolerance to arsenic stress.
  5. Data show that Fps1p in concert with the arsenite transporter Acr3p mediates arsenite efflux.
    Title: The yeast aquaglyceroporin Fps1p is a bidirectional arsenite channel.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables antimonite transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables antimonite transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables antiporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables arsenite transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arsenite transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables arsenite transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables inorganic anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antimonite transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antimonite transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in arsenite transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arsenite transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to arsenic-containing substance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Arr3p
NP_015527.1
  • Plasma membrane metalloid/H+ antiporter; member of bile/arsenite/riboflavin transporter (BART) superfamily; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite; protein displays 10 transmembrane segments with cytoplasmically oriented N- and C-terminal domains

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    939922..941136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184298.1 → NP_015527.1  TPA: Arr3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015527.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4J9, Q06598
    UniProtKB/TrEMBL
    A6ZX73, B5VTX7, C7GP79, C8ZJN0, N1NWL6
    Conserved Domains (1) summary
    TIGR00832
    Location:30 → 391
    acr3; arsenical-resistance protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06598.1

Gene LinkOut

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