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RPL11A 60S ribosomal protein uL5 RPL11A [ Saccharomyces cerevisiae S288C ]

Gene ID: 856217, updated on 7-Jun-2026
Official Symbol
RPL11A
Official Full Name
60S ribosomal protein uL5 RPL11A
Primary source
SGD:S000006306
Locus tag
YPR102C
See related
AllianceGenome:SGD:S000006306; FungiDB:YPR102C; VEuPathDB:YPR102C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Involved in ribosomal large subunit assembly. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 7 and T-cell acute lymphoblastic leukemia. Orthologous to human RPL11 (ribosomal protein L11). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See RPL11A in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (731224..731748, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial 54S ribosomal protein mL43 MRPL51 Neighboring gene Snt309p Neighboring gene proteasome core particle subunit beta 5 Neighboring gene Fhl1p

Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A flexible loop in yeast ribosomal protein L11 coordinates P-site tRNA binding. Rhodin MH, et al. Nucleic Acids Res, 2010 Dec. PMID 20705654, Free PMC Article
  2. Functional analysis of the uL11 protein impact on translational machinery. Wawiórka L, et al. Cell Cycle, 2016. PMID 26939941, Free PMC Article
  3. Structural dynamics of the yeast Shwachman-Diamond syndrome protein (Sdo1) on the ribosome and its implication in the 60S subunit maturation. Ma C, et al. Protein Cell, 2016 Mar. PMID 26850260, Free PMC Article
  4. The central core region of yeast ribosomal protein L11 is important for subunit joining and translational fidelity. Rhodin MH, et al. Mol Genet Genomics, 2011 Jun. PMID 21519857, Free PMC Article
  5. Depletion of yeast ribosomal proteins L16 or rp59 disrupts ribosome assembly. Moritz M, et al. J Cell Biol, 1990 Dec. PMID 2277060, Free PMC Article

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IC
Inferred by Curator
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in ribosomal large subunit assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm EXP
Inferred from Experiment
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus EXP
Inferred from Experiment
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
60S ribosomal protein uL5 RPL11A
NP_015427.1
  • Ribosomal 60S subunit protein L11A; expressed at twice the level of Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11A has a paralog, RPL11B, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    731224..731748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184199.1 → NP_015427.1  60S ribosomal protein uL5 RPL11A

    See identical proteins and their annotated locations for NP_015427.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4A0, P06380, P0C0W9
    UniProtKB/TrEMBL
    A0ABF7PIP2, A6ZWY2, B3LK66, C8ZJC4, G2WPR8
    Conserved Domains (1) summary
    PTZ00156
    Location:2 → 172
    PTZ00156; 60S ribosomal protein L11; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C0W9.2

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