U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LEA1 U2 snRNP complex subunit LEA1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855888, updated on 31-May-2023

Summary

Gene symbol
LEA1
Gene description
U2 snRNP complex subunit LEA1
Primary source
SGD:S000006134
Locus tag
YPL213W
See related
AllianceGenome:SGD:S000006134
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable U2 snRNA binding activity. Involved in mRNA splicing, via spliceosome. Located in cytoplasm. Part of U2 snRNP and U2-type prespliceosome. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPA1 (small nuclear ribonucleoprotein polypeptide A'). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See LEA1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (150614..151330)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Cbp3p Neighboring gene bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase Neighboring gene pseudouridine synthase PUS1 Neighboring gene ribosome biosynthesis protein NIP7

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables U2 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables U2 snRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of U2 snRNP IDA
Inferred from Direct Assay
more info
PubMed 
part_of U2 snRNP IPI
Inferred from Physical Interaction
more info
PubMed 
part_of U2-type prespliceosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
U2 snRNP complex subunit LEA1
NP_015111.1
  • Component of U2 snRNP complex; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    150614..151330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184027.1NP_015111.1  TPA: U2 snRNP complex subunit LEA1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015111.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3F7, Q08963
    UniProtKB/TrEMBL
    A0A6A5Q2G3, A6ZW42, B3LKL7, C8ZIG6, N1P2L4
    Conserved Domains (2) summary
    COG4886
    Location:12237
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:5475
    LRR_1; leucine-rich repeat [structural motif]