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LEA1 U2 snRNP complex subunit LEA1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855888, updated on 18-Sep-2024

Summary

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Official Symbol
LEA1
Official Full Name
U2 snRNP complex subunit LEA1
Primary source
SGD:S000006134
Locus tag
YPL213W
See related
AllianceGenome:SGD:S000006134; FungiDB:YPL213W; VEuPathDB:YPL213W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable U2 snRNA binding activity. Involved in mRNA splicing, via spliceosome. Located in cytoplasm. Part of U2 snRNP and U2-type prespliceosome. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPA1 (small nuclear ribonucleoprotein polypeptide A'). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (150614..151330)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Cbp3p Neighboring gene bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase Neighboring gene pseudouridine synthase PUS1 Neighboring gene ribosome biosynthesis protein NIP7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yeast U2A'/U2B complex is required for pre-spliceosome formation. Caspary F, et al. EMBO J, 1998 Nov 2. PMID 9799242, Free PMC Article
  2. The identification and characterization of a novel splicing protein, Isy1p, of Saccharomyces cerevisiae. Dix I, et al. RNA, 1999 Mar. PMID 10094305, Free PMC Article
  3. Cotranscriptional spliceosome assembly dynamics and the role of U1 snRNA:5'ss base pairing in yeast. Lacadie SA, et al. Mol Cell, 2005 Jul 1. PMID 15989965
  4. Partial purification of the yeast U2 snRNP reveals a novel yeast pre-mRNA splicing factor required for pre-spliceosome assembly. Caspary F, et al. EMBO J, 1999 Jun 15. PMID 10369685, Free PMC Article
  5. H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast. Shieh GS, et al. BMC Genomics, 2011 Dec 22. PMID 22188810, Free PMC Article

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables U2 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U2 snRNP IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of U2-type prespliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U2 snRNP complex subunit LEA1
NP_015111.1
  • Component of U2 snRNP complex; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    150614..151330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184027.1 → NP_015111.1  TPA: U2 snRNP complex subunit LEA1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015111.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3F7, Q08963
    UniProtKB/TrEMBL
    A6ZW42, B3LKL7, B5VSW7, C7GN40, C8ZIG6, G2WNX2, N1P2L4
    Conserved Domains (2) summary
    COG4886
    Location:12 → 237
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:54 → 75
    LRR_1; leucine-rich repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08963.1

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