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BIO4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855794, updated on 22-Aug-2024

Summary

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Official Symbol
BIO4
Primary source
FungiDB:YNR057C
Locus tag
YNR057C
See related
SGD:S000005340; AllianceGenome:SGD:S000005340; VEuPathDB:YNR057C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables dethiobiotin synthase activity. Involved in biotin biosynthetic process. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (733356..734069, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Hol1p Neighboring gene Bio5p Neighboring gene adenosylmethionine-8-amino-7-oxononanoate transaminase Neighboring gene putative alpha-1,3-mannosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The reacquisition of biotin prototrophy in Saccharomyces cerevisiae involved horizontal gene transfer, gene duplication and gene clustering. Hall C, et al. Genetics, 2007 Dec. PMID 18073433, Free PMC Article
  2. Characterization of the biotin biosynthesis pathway in Saccharomyces cerevisiae and evidence for a cluster containing BIO5, a novel gene involved in vitamer uptake. Phalip V, et al. Gene, 1999 May 17. PMID 10333520
  3. Biotin sensing in Saccharomyces cerevisiae is mediated by a conserved DNA element and requires the activity of biotin-protein ligase. Pirner HM, et al. J Biol Chem, 2006 May 5. PMID 16531611
  4. Transcriptional remodeling in response to iron deprivation in Saccharomyces cerevisiae. Shakoury-Elizeh M, et al. Mol Biol Cell, 2004 Mar. PMID 14668481, Free PMC Article
  5. A nutrient-responsive pathway that determines M phase timing through control of B-cyclin mRNA stability. Messier V, et al. Cell, 2013 May 23. PMID 23706744

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables dethiobiotin synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dethiobiotin synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dethiobiotin synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biotin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biotin biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in biotin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biotin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
dethiobiotin synthase
NP_014455.1
  • Dethiobiotin synthetase; catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria; expression appears to be repressed at low iron levels

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    733356..734069 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183234.1 → NP_014455.1  TPA: dethiobiotin synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014455.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1N2, P53630
    UniProtKB/TrEMBL
    A6ZSD1, B3LPI6, B5VR82, C7GIY8, C8ZFT6, G2WLB4, N1NWV6
    Conserved Domains (1) summary
    TIGR00347
    Location:15 → 186
    bioD; dethiobiotin synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53630.1

Gene LinkOut

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