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BIO4 dethiobiotin synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855794, updated on 27-Jan-2024

Summary

Gene symbol
BIO4
Gene description
dethiobiotin synthase
Primary source
SGD:S000005340
Locus tag
YNR057C
See related
AllianceGenome:SGD:S000005340
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables dethiobiotin synthase activity. Involved in biotin biosynthetic process. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See BIO4 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (733356..734069, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Hol1p Neighboring gene Bio5p Neighboring gene adenosylmethionine-8-amino-7-oxononanoate transaminase Neighboring gene putative alpha-1,3-mannosyltransferase

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables dethiobiotin synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dethiobiotin synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables dethiobiotin synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biotin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in biotin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in biotin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in biotin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
dethiobiotin synthase
NP_014455.1
  • Dethiobiotin synthetase; catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria; expression appears to be repressed at low iron levels

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    733356..734069 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183234.1NP_014455.1  TPA: dethiobiotin synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014455.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1N2, P53630
    UniProtKB/TrEMBL
    A0A8H4BWW8, A6ZSD1, B3LPI6, B5VR82, C7GIY8, C8ZFT6, G2WLB4, N1NWV6
    Conserved Domains (1) summary
    TIGR00347
    Location:15186
    bioD; dethiobiotin synthase