SEC12 Sar family guanine nucleotide exchange factor SEC12 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: SEC12
Gene description: Sar family guanine nucleotide exchange factor SEC12
Primary source: FungiDB:YNR026C
Locus tag: YNR026C
See related: SGD:S000005309; AllianceGenome:SGD:S000005309; VEuPathDB:YNR026C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SED2
Summary: Enables guanyl-nucleotide exchange factor activity. Involved in regulation of COPII vesicle coating. Located in Golgi apparatus and endoplasmic reticulum. Used to study autism spectrum disorder; cranioectodermal dysplasia; and intellectual disability. Orthologous to human PREB (prolactin regulatory element binding). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SEC12 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (673274..674689, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural basis for the initiation of COPII vesicle biogenesis.
Title: Structural basis for the initiation of COPII vesicle biogenesis.
The structure of Sec12 implicates potassium ion coordination in Sar1 activation.
Title: The structure of Sec12 implicates potassium ion coordination in Sar1 activation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of COPII vesicle coating	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of COPII vesicle coating	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Sar family guanine nucleotide exchange factor SEC12

NP_014423.1

Guanine nucleotide exchange factor (GEF); activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER; SEC12 has a paralog, SED4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

673274..674689 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183203.1 → NP_014423.1 TPA: Sar family guanine nucleotide exchange factor SEC12 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014423.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1K0, P11655

UniProtKB/TrEMBL

A0A8H4BW62, A6ZS99, B3LPL8, C7GLN2, C8ZFQ3, G2WL82, N1P4R6

Conserved Domains (2) summary

COG2319
Location:79 → 335

WD40; WD40 repeat [General function prediction only]

sd00039
Location:177 → 212

7WD40; WD40 repeat [structural motif]