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SEC12 Sar family guanine nucleotide exchange factor SEC12 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855760, updated on 3-May-2025
Official Symbol
SEC12
Official Full Name
Sar family guanine nucleotide exchange factor SEC12
Primary source
SGD:S000005309
Locus tag
YNR026C
See related
AllianceGenome:SGD:S000005309; FungiDB:YNR026C; VEuPathDB:YNR026C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SED2
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in regulation of COPII vesicle coating. Located in Golgi apparatus and endoplasmic reticulum. Used to study autism spectrum disorder; cranioectodermal dysplasia; and intellectual disability. [provided by Alliance of Genome Resources, May 2025]
Orthologs
all
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See SEC12 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (673274..674689, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Snf12p Neighboring gene Mpp6p Neighboring gene putative pyridoxal kinase BUD17 Neighboring gene peptidylprolyl isomerase family protein CPR8

Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Expression, purification, and assay of Sec12p: a Sar1p-specific GDP dissociation stimulator. Barlowe C, et al. Methods Enzymol, 1995. PMID 8583945
  2. Purification, crystallization and preliminary X-ray diffraction analysis of the yeast Sec12Deltap protein, a guanine nucleotide-exchange factor involved in vesicle transport. Dumon-Seignovert L, et al. Acta Crystallogr D Biol Crystallogr, 2001 Jun. PMID 11375521
  3. The yeast Sar exchange factor Sec12, and its higher organism orthologs, fold as beta-propellers. Chardin P, et al. FEBS Lett, 2002 Aug 14. PMID 12163183
  4. A membrane glycoprotein, Sec12p, required for protein transport from the endoplasmic reticulum to the Golgi apparatus in yeast. Nakano A, et al. J Cell Biol, 1988 Sep. PMID 3047151, Free PMC Article
  5. SEC12 encodes a guanine-nucleotide-exchange factor essential for transport vesicle budding from the ER. Barlowe C, et al. Nature, 1993 Sep 23. PMID 8377826

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural basis for the initiation of COPII vesicle biogenesis.
    Title: Structural basis for the initiation of COPII vesicle biogenesis.
  2. The structure of Sec12 implicates potassium ion coordination in Sar1 activation.
    Title: The structure of Sec12 implicates potassium ion coordination in Sar1 activation.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of COPII vesicle coating IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of COPII vesicle coating IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Sar family guanine nucleotide exchange factor SEC12
NP_014423.1
  • Guanine nucleotide exchange factor (GEF); activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER; SEC12 has a paralog, SED4, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    673274..674689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183203.1 → NP_014423.1  TPA: Sar family guanine nucleotide exchange factor SEC12 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014423.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1K0, P11655
    UniProtKB/TrEMBL
    A6ZS99, B3LPL8, C7GLN2, C8ZFQ3, G2WL82, N1P4R6
    Conserved Domains (2) summary
    COG2319
    Location:79 → 335
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:177 → 212
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11655.1

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