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SEC12 Sar family guanine nucleotide exchange factor SEC12 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855760, updated on 18-Jan-2023

Summary

Gene symbol
SEC12
Gene description
Sar family guanine nucleotide exchange factor SEC12
Primary source
SGD:S000005309
Locus tag
YNR026C
See related
AllianceGenome:SGD:S000005309
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SED2
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in regulation of COPII vesicle coating. Located in Golgi apparatus and endoplasmic reticulum. Used to study autism spectrum disorder; cranioectodermal dysplasia; and intellectual disability. Orthologous to human PREB (prolactin regulatory element binding). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See SEC12 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (673274..674689, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Snf12p Neighboring gene Mpp6p Neighboring gene putative pyridoxal kinase BUD17 Neighboring gene peptidylprolyl isomerase family protein CPR8

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
enables guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of COPII vesicle coating IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of COPII vesicle coating IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Sar family guanine nucleotide exchange factor SEC12
NP_014423.1
  • Guanine nucleotide exchange factor (GEF); activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER; SEC12 has a paralog, SED4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    673274..674689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183203.1NP_014423.1  TPA: Sar family guanine nucleotide exchange factor SEC12 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014423.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1K0, P11655
    UniProtKB/TrEMBL
    A0A0L8VJS2, A0A8H4BW62, A6ZS99, B3LPL8, C7GLN2, C8ZFQ3, H0GMU4, N1P4R6
    Conserved Domains (2) summary
    COG2319
    Location:79335
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:177212
    7WD40; WD40 repeat [structural motif]